Registration Dossier
Registration Dossier
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EC number: 233-007-4 | CAS number: 10016-20-3
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The read-across test substance .beta.-cyclodextrin has no toxic effects on survival and reproduction of Daphnia magna after an exposure period of 21 days up to the highest test concentration of 120 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 120 mg/L
Additional information
The read-across approach based on grouping of substances (category approach) is used due to the following reason: .alpha.-, .beta.- and .gamma.-cyclodextrin consist of α-D-glucopyranoside units in a ring structure of 6, 7, and 8 units, respectively. Water solubility of these compounds is between 18 and 232 g/L at 25°C. The typical biodegradation route is a ring opening in the first step and then cleavage to oligo- or mono-saccharide units and further metabolisation to CO2. All degradation intermediates are practical nontoxic. Bioaccumulation is not expected due to the log Pow values ranging from -12.02 up to -7.77.
The effect of the read-across substance .beta.-cyclodextrin on the survival and reproduction of Daphnia magna was investigated in a semi-static test over 21 days following the OECD Guidelines for Testing of Chemicals, No. 211 (2008): “Daphnia magna Reproduction Test” and Commission Regulation (EC) No 440/2008, C.20: “Daphnia magna Reproduction Test”. The test substance had no toxic effects on survival and reproduction of Daphnia magna after an exposure period of 21 days up to the highest test concentration of 120 mg/L.
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