Previous Testing Proposals

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

Showing 1,601 - 1,650 of 2,011 results.

Name	EC Number	CAS Number	Hazard endpoint for which vertebrate testing was proposed	Date of publication to call for available information	Deadline for submitting information
1,4-Cyclohexanedicarboxylic acid, 1,4-diisononyl ester	701-012-5	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	10/12/2018 10/12/2018	24/01/2019 24/01/2019	Details
1-(4-(ACETYLOXY)-3-((ACETYLOXY)METHYL)PHENYL)ETHANONE	921-042-4	-	Genetic toxicity in vivo	25/05/2020	09/07/2020	Details
1-[(2-tert-butylcyclohexyl)oxy]butan-2-ol	412-300-2	-	Reproductive toxicity (pre-natal developmental toxicity)	18/02/2021	05/04/2021	Details
1-acetyl-4-(3-dodecyl-2,5-dioxo-1-pyrrolidinyl)-2,2,6,6-tetramethylpiperidine	411-930-5	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	28/11/2022 28/11/2022	12/01/2023 12/01/2023	Details
1-isocyanato-2(or 4)-(4-isocyanatobenzyl)benzene and their reaction products with [(methylethylene)bis(oxy)]dipropanol and butane-1,3-diol and propylene glycol	701-029-8	-	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC 202-966-0)	01/04/2022	16/05/2022	Details
1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18(even numbered) acyl) derivs., hydroxides, inner salts	939-457-4	-	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/09/2014 18/09/2014 18/09/2014	03/11/2014 03/11/2014 03/11/2014	Details
1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts	939-455-3	-	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): oral	18/09/2014 18/09/2014 18/09/2014	03/11/2014 03/11/2014 03/11/2014	Details
2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with Propylene oxide and n-butyl glycidyl ether	926-564-6	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	21/10/2019 21/10/2019	05/12/2019 05/12/2019	Details
2,2-bis(hydroxymethyl)propionic acid // 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid	225-306-3	-	Reproductive toxicity (pre-natal developmental toxicity study) Sub-chronic oral toxicity (90-day): oral	05/04/2011 05/04/2011	20/05/2011 20/05/2011	Details
2,4,8,10-Tetraoxaspiro[5.5]undecane-3,9-diethanol, .beta.3,.beta.3,.beta.9,.beta.9-tetramethyl-	485-230-3	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	28/11/2022 28/11/2022	12/01/2023 12/01/2023	Details
2,4-dimethyl-6-(1-methyl-pentadecyl)phenol	411-220-5	-	Reproductive toxicity (pre-natal developmental toxicity)	25/09/2012	12/11/2012	Details
2-(2-Vinyloxyethoxy)ethyl acrylate	451-690-9	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	20/12/2017 20/12/2017	05/02/2018 05/02/2018	Details
2-[2,2-bis(2-prop-2-enoyloxyethoxymethyl)butoxy]ethyl 3-(dibutylamino)propanoate	701-363-4	-	Sub-chronic toxicity (90-day): oral	26/08/2021	11/10/2021	Details
2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone	404-360-3	-	Reproductive toxicity (pre-natal developmental toxicity)	24/05/2013	08/07/2013	Details
2-Butyne-1,4-diol, polymer with 2-(chloromethyl)oxirane, brominated, dehydrochlorinated, methoxylated	614-503-3	-	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): inhalation	15/04/2011 15/04/2011 15/04/2011	30/05/2011 30/05/2011 30/05/2011	Details
2-ethoxyethyl-2-(4-(2,6-dihydro-2,6-dioxo-7-phenyl-1,5-dioxaindacen-3-yl)phenoxy)acetate	403-960-2	-	Genetic toxicity in vivo	03/10/2023	17/11/2023	Details
2-ethyl-N,N-bis(2-ethylhexyl)hexylamine	217-461-0	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/01/2012 16/01/2012	01/03/2012 01/03/2012	Details
2-propenoic acid, butyl ester, reaction products with butadiene and sulfur	947-895-2	-	Bioaccumulation aquatic / sediment Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/01/2024 15/01/2024 15/01/2024 15/01/2024	29/02/2024 29/02/2024 29/02/2024 29/02/2024	Details
2-Propyn-1-ol, reaction product with 1-2.5 moles of oxirane	941-793-1	-	Reproductive toxicity (pre-natal developmental toxicity)	26/04/2019	10/06/2019	Details
2-Propyn-1-ol, reaction product with 1-2.5 moles of oxirane	941-793-1	-	Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with 2-Propyn-1-ol, compd. with methyloxirane (EC 609-530-2, CAS 38172-91-7)	17/04/2015	04/06/2015	Details
2-{N-[2,6-Diamino-4-oxo-4H-pyrimidin-(5Z)-ylidene]-hydrazino}-5-methyl-benzenesulfonic acid	700-002-8	-	Reproductive toxicity (pre-natal developmental toxicity)	16/07/2012	30/08/2012	Details
3,4-dihydroxy-1-[(Z)-octadec-9-enyl]pyrrolidine-2,5-dione	700-233-4	-	Bioaccumulation aquatic / sediment Long-term toxicity to fish Sub-chronic toxicity (90-day): oral	04/09/2023 04/09/2023 04/09/2023	19/10/2023 19/10/2023 19/10/2023	Details
3,5,5-trimethylhexanoic acid	221-975-0	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	31/05/2011 31/05/2011	15/07/2011 15/07/2011	Details
3,5-bis(2,4-dimethylcyclohex-3-en-1-yl)polyheterocycle	-	-	Genetic toxicity in vivo	16/03/2015	30/04/2015	Details
3,6-bis(4-chlorophenyl)-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione	401-540-3	-	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	26/03/2018 26/03/2018 26/03/2018	11/05/2018 11/05/2018 11/05/2018	Details
3,6-bis(4-tert-butylphenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione	416-250-2	-	Reproductive toxicity (two-generation reproductive toxicity)	25/09/2012	12/11/2012	Details
3,6-bis-biphenyl-4-yl-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione	413-920-6	-	Reproductive toxicity (two-generation reproductive toxicity)	25/09/2012	12/11/2012	Details
3-((5-(3-(Dodecanoyloxy)-2,2-dimethylpropylideneamino)-1,3,3-trimethylcyclohexyl)methylimino)-2,2-dimethylpropyl dodecanoate	700-071-4	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/05/2012 16/05/2012	02/07/2012 02/07/2012	Details
3-((C9-11-iso,C10-rich)alkyloxy)propan-1-amine	939-485-7	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	02/06/2014 02/06/2014	17/07/2014 17/07/2014	Details
3-((C9-11-iso,C10-rich)alkyloxy)propan-1-amine acetate (1:1)	939-448-5	-	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: Testing proposed with 1-Propanamine, 3-((C9-11-iso-,C10-rich)alkyloxy)- Sub-chronic toxicity (90-day): oral \|\| Note: Testing proposed with 1-Propanamine, 3-((C9-11-iso-,C10-rich)alkyloxy)-	02/06/2014 02/06/2014	17/07/2014 17/07/2014	Details
3-(Diisobutoxy-thiophosphorylsulfanyl)-2-methyl-propionic acid	434-070-2	-	Sub-chronic toxicity (90-day): oral	18/02/2013	04/04/2013	Details
3-[(5-cyano-6-hydroxy-1,4-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)diazenyl]phenyl benzoate	953-951-7	-	7.6.2 Genetic toxicity in vivo	08/03/2024	22/04/2024	Details
3-[(diisoalkyloxyphosphorothioyl)thio]-2-methylalkanoic acid	-	-	Developmental toxicity (pre-natal developmental toxicity)	15/03/2011	29/04/2011	Details
3-C12-14-(even numbered)-alkylamido-N,N-dimethylpropan-1-amino oxide	931-324-9	-	Sub-chronic toxicity (90-day): oral	02/09/2011	17/10/2011	Details
3-C12-18-(even numbered)-alkylamido-N,N-dimethylpropan-1-amino oxide	939-581-9	-	Reproductive toxicity (pre-natal developmental toxicity)	26/03/2018	11/05/2018	Details
3-methyldecane; benzene; cyclooctane; nonane	941-364-9	-	Reproductive toxicity (extended one-generation reproductive toxicity study)	05/07/2018	20/08/2018	Details
3-{[3-(C10-16-oxy)propyl]amino}propan-1-aminium acetate	941-152-6	-	Sub-chronic toxicity (90-day): oral\|\|Note: testing proposed with 1,3-propanediamine, N-[3-((C11-14, C13-rich)oxy)propyl]-branched acetate (EC: 931-295-2)	15/07/2022	29/08/2022	Details
4'-Ethyl-2,3-difluorbiphenyl-4-boronic acid	929-209-3	-	Genetic toxicity in vivo	16/12/2020	01/02/2021	Details
4,4'-(9H-fluoren-9-ylidene)bis(2-chloroaniline)	407-560-9	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	17/06/2020 17/06/2020	03/08/2020 03/08/2020	Details
4,4'-Isopropylidenediphenol, ethoxylated	500-082-2	-	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	21/05/2018 21/05/2018 21/05/2018	05/07/2018 05/07/2018 05/07/2018	Details
4,4'-methylenediphenyl diisocyanate and its oligomeric reaction products with oxydipropanol and [(methylethylene)bis(oxy)]dipropanol	701-072-2	-	Reproductive toxicity (extended one-generation reproductive toxicity study)\|\| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no: 202-966-0)	16/06/2022	01/08/2022	Details
5-Methoxy-2-tetralone	457-080-9	-	Genetic toxicity in vivo	06/09/2018	22/10/2018	Details
7-amino-3,8-bis-[4-(2-sulfoxyethylsulfonyl)-2-sulfophenylazo]-4-hydroxynaphthalene-2-sulfonic acid, Na/K salt; 7-amino-3-[4-(2-sulfoxyethylsulfonyl)phenylazo]-4-hydroxy-8-[4-(2-sulfoxyethylsulfonyl)-2-sulfophenylazo]naphthalene-2-sulfonic acid, Na/K salt; 7-amino-8-[4-(2-sulfoxyethylsulfonyl)-phenylazo]-4-hydroxy-3-[4-(2-sulfoxyethylsulfonyl)-2-sulfophenylazo]naphthalene-2-sulfonic acid, Na/K salt; reaction mass of: 7-amino-3,8-bis-[4-(2-sulfoxyethylsulfonyl)phenylazo]-4-hydroxynaphthalene-2-sulfonic acid, Na/K salt	429-070-4	-	Sub-chronic toxicity (90-day): oral	22/04/2021	07/06/2021	Details
A dried sludge product resulting from the treatment process of domestic wastewater. The exact processes followed for the production of the dried sludge are: Preliminary and secondary treatment of the wastewater stream, thickening, dehydration and drying of the excess sludge.	943-834-9	-	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	03/04/2023 03/04/2023 03/04/2023	22/05/2023 22/05/2023 22/05/2023	Details
A mixture of: esters of C14-C15 branched alcohols with 3,5-di-t-butyl-4-hydroxyphenyl propionic acid; C15 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate; C13 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate	413-750-2	-	Reproductive toxicity (pre-natal developmental toxicity)	30/09/2021	15/11/2021	Details
A mixture of: tetrasodium-phosphonoethane-1,2-dicarboxylate,hexasodium-phosphonobutane-1,2,3,4-tetracarboxylate	410-800-5	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	06/03/2012 06/03/2012	20/04/2012 20/04/2012	Details
A mixture of: α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-hydroxypoly(oxyethylene),α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyloxypoly(oxyethylene)	400-830-7	-	Reproductive toxicity (pre-natal developmental toxicity)	16/12/2011	30/01/2012	Details
Acetalization products between glucose and C16-18(even numbered)- alcohol	927-870-2	-	Sub-chronic toxicity (90-day): oral	15/09/2011	31/10/2011	Details
Acetalization products between glucose and C20-22(even numbered)- alcohol	923-835-0	-	Sub-chronic toxicity (90-day): oral	15/09/2011	31/10/2011	Details
Activated Carbon - High Density Skeleton	931-328-0	-	Sub-chronic toxicity (90 day): inhalation	16/06/2011	01/08/2011	Details

Showing 1,601 - 1,650 of 2,011 results.

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