Registered substances

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The new ECHA CHEM database has been released by ECHA. At first this system will contain only substances and data from REACH registration dossiers. For new and updated REACH registration data please check ECHA CHEM. See for more information on the transition to ECHA CHEM.  More

Please be aware that REACH registration data here on the current Dissemination Platform is no longer maintained; it remains frozen as of 19th May 2023.


 

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Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



No results were found
Details
(2S,3S)-2,3-Dihydroxysuccinic acid - (2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide (1:2)
954-871-5 - Active Intermediate Individual Intermediate use only 19-08-2021 View substance registered dossier
(2S,3S)-2,3-dihydroxysuccinic acid - 2-[(3R)-piperidin-3-yl]-1H-isoindole-1,3(2H)-dione (1:1)
692-713-4 886588-62-1 Active Intermediate Joint Intermediate use only 20-12-2019 View substance registered dossier
(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine
831-973-7 147116-67-4 Active Full Joint ≥ 1 to < 10 tonnes 15-08-2019 View substance registered dossier
(2S,3S)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylammonium methanesulfonate
425-530-3 98769-75-6 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride
478-270-8 - No longer Valid Intermediate Individual No longer valid 19-10-2012 View substance registered dossier
(2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride
478-270-8 - Cease Manufacture Intermediate Individual Cease manufacture 05-11-2012 View substance registered dossier
(2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride
478-270-8 - No longer Valid Intermediate Joint No longer valid 04-09-2012 View substance registered dossier
(2S,3S)-di-tert-butyl 3-ethyl-4-oxopyrrolidine-1,2-dicarboxylate
942-044-1 - Active Intermediate Joint Intermediate use only 27-02-2017 View substance registered dossier
(2S,3S,3aR,9aS)-3-hydroxy-2-(hydroxymethyl)-7-methyl-2,3,3a,9a-tertryhydro-6H-furo[2’,3’:4,5][1,3]oxazolo [3,2-a]pyrimidin-6-one
700-330-1 433733-92-7 Active Full Individual ≥ 0 to < 10 tonnes 16-04-2019 View substance registered dossier
(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate
917-270-9 29790-50-9 Active Full Joint ≥ 1 to < 10 tonnes 26-08-2022 View substance registered dossier
(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate
917-270-9 29790-50-9 Active Intermediate Joint Intermediate use only 10-06-2020 View substance registered dossier
(2S,3S,4R)-2-aminooctadecane-1,3,4-triol
439-210-6 554-62-1 Active Full Joint ≥ 10 to < 100 tonnes 19-08-2022 View substance registered dossier
(2S,3S,4R)-2-aminooctadecane-1,3,4-triol
439-210-6 554-62-1 Active NONS Individual Tonnage data confidential 02-09-2011 View substance registered dossier
(2S,3S,4R)-3-ethyl-4-hydroxy-2-(methoxycarbonyl)pyrrolidinium 4-methylbenzenesulfonate
813-641-3 1799733-43-9 Active Intermediate Joint Intermediate use only 18-04-2018 View substance registered dossier
(2S,3S,4R)-methyl 4-((3-(1,1-difluorobut-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-3-ethylpyrrolidine-2-carboxylate 4-methylbenzenesulfonate
942-021-6 1799733-71-3 Active Intermediate Joint Intermediate use only 14-02-2018 View substance registered dossier
(2S,3S,5R)-2-hexyl-3-hydroxy-5-(phenylmethoxy)-Hexadecanoic acid compd. with (S)-α-methylbenzenemethanamine (1:1)
604-018-5 137433-01-3 Cease Manufacture Intermediate Joint Cease manufacture 04-12-2012 View substance registered dossier
(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
618-303-7 89786-04-9 Active Intermediate Joint Intermediate use only 12-03-2018 View substance registered dossier
(2S,3S,5S)-5-amino-2-(dibenzylamino)-1,6-diphenylhexan-3-ol succinate
938-481-2 - Active Intermediate Joint Intermediate use only 31-10-2018 View substance registered dossier
(2S,4aR)-1,1,5,5-tetramethyl-1,3,4,5,6,7-hexahydro-2H-2,4a-methanonaphthalen-7-ol
942-036-8 645413-57-6 Active Intermediate Joint Intermediate use only 01-07-2020 View substance registered dossier
(2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester
411-020-8 - Active Intermediate Joint Intermediate use only 09-12-2013 View substance registered dossier
(2S,4R)-1-hexadecanoyl-4-hydroxy-pyrrolidine-2-carboxylic acid
944-347-4 - Active Intermediate Joint Intermediate use only 13-03-2017 View substance registered dossier
(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
604-011-7 13726-69-7 Active Intermediate Joint Intermediate use only 20-04-2022 View substance registered dossier
(2S,4S) 4-Hydroxymethyl-pyrrolidine-1,2-dicarboxylic acid 1-butyl ester 2-methyl ester
807-618-7 1194059-42-1 Active Intermediate Individual Intermediate use only 20-04-2016 View substance registered dossier
(2S,4S)-1-(tert-butoxycarbonyl)-4-(hydroxymethyl)pyrrolidine-2-carboxylic acid
812-482-7 1643468-66-9 Active Intermediate Individual Intermediate use only 17-05-2016 View substance registered dossier
(2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carboxylic acid
807-416-9 1378388-16-9 Active Intermediate Joint Intermediate use only 20-04-2018 View substance registered dossier
(2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one
423-090-7 156732-13-7 Active Intermediate Joint Intermediate use only 12-06-2018 View substance registered dossier
(2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one
423-090-7 156732-13-7 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxamide
812-263-6 1416134-49-0 Active Intermediate Individual Intermediate use only 10-05-2016 View substance registered dossier
(2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide
427-200-4 76646-91-8 Active NONS Joint Tonnage data confidential 15-12-2008 View substance registered dossier
(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
812-287-7 1192651-49-2 Active Intermediate Individual Intermediate use only 17-05-2016 View substance registered dossier
(2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid
811-415-9 1335316-40-9 Active Intermediate Joint Intermediate use only 07-03-2018 View substance registered dossier
(2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
255-799-0 42399-49-5 Active Intermediate Joint Intermediate use only 19-10-2018 View substance registered dossier
(2S-cis)-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid
444-810-6 - Active Full Joint ≥ 10 to < 100 tonnes 11-05-2021 View substance registered dossier
(2S-cis)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
255-795-9 42399-40-6 Active Intermediate Joint Intermediate use only 09-04-2018 View substance registered dossier
(2S-trans)-3-amino-2-methyl-4-oxoazetidine-1-sulphonic acid
279-393-8 80082-65-1 Active Intermediate Joint Intermediate use only 10-03-2023 View substance registered dossier
(2Z)-(5-amino-1,2,4-thiadiazol-3-yl)(ethoxyimino)acetic acid
616-178-3 75028-24-9 Active Intermediate Joint Intermediate use only 26-06-2020 View substance registered dossier
(2Z)-(5-amino-1,2,4-thiadiazol-3-yl)(ethoxyimino)acetic acid
616-178-3 75028-24-9 No longer Valid Intermediate Individual No longer valid 24-06-2013 View substance registered dossier
(2Z)-1,1,1,4,4,4-hexafluorobut-2-ene
700-651-7 692-49-9 Active Full Joint ≥ 100 to < 1 000 tonnes 27-09-2019 View substance registered dossier
(2Z)-2-(2-{[(benzyloxy)carbonyl]amino}-1,3-thiazol-4-yl)-5-[(3-methylbut-2-en-1-yl)oxy]-5-oxopent-2-enoic acid
889-755-2 102199-30-4 Active Intermediate Joint Intermediate use only 22-03-2023 View substance registered dossier
(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[2-methyl-1-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]oxyiminoacetic acid
616-285-5 76028-96-1 Active Intermediate Individual Intermediate use only 26-04-2013 View substance registered dossier
(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[2-methyl-1-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]oxyiminoacetic acid
616-285-5 76028-96-1 Active Intermediate Joint Intermediate use only 09-06-2022 View substance registered dossier
(2Z)-2-chloro-3-(dimethylamino)-N,N-dimethylprop-2-en-1-iminium hexafluorophosphate
619-785-1 249561-98-6 Active Intermediate Individual Intermediate use only 23-05-2011 View substance registered dossier
(2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal
813-789-9 152873-67-1 Active Intermediate Joint Intermediate use only 18-10-2022 View substance registered dossier
(2Z)-2-phenylhex-2-enenitrile
482-160-5 130786-09-3 Active Full Joint ≥ 10 to < 100 tonnes 05-07-2022 View substance registered dossier
(2Z)-2-phenylhex-2-enenitrile
482-160-5 130786-09-3 Active Intermediate Joint Intermediate use only 07-06-2018 View substance registered dossier
(2Z)-2-phenylhex-2-enenitrile
482-160-5 130786-09-3 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(2Z)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)but-2-en-1-one
616-378-0 767340-03-4 Active Intermediate Individual Intermediate use only 08-10-2012 View substance registered dossier
(2Z)-4,8-dimethylnona-2,7-dien-4-ol
807-754-7 89929-57-7 Active Full Joint ≥ 1 to < 10 tonnes 21-10-2022 View substance registered dossier
(2Z)-7-chloro-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid
618-065-4 877674-77-6 Active Intermediate Joint Intermediate use only 13-09-2017 View substance registered dossier
(2Z)-but-2-ene-1,4-diyl diacetate
607-674-0 25260-60-0 Active Intermediate Joint Intermediate use only 06-12-2019 View substance registered dossier
No results were found
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
Excella GmbH & Co. KG Nuernberger Str. 12 90537 Feucht Germany Germany Active (2S,3S)-2,3-Dihydroxysuccinic acid - (2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide (1:2) 954-871-5 - - View substance registered dossier
Bidachem S.p.A. S.S. 11 Padana Superiore No. 8 24040 Fornovo San Giovanni BG Italy Italy Active (2S,3S)-2,3-dihydroxysuccinic acid - 2-[(3R)-piperidin-3-yl]-1H-isoindole-1,3(2H)-dione (1:1) 692-713-4 886588-62-1 2019 View substance registered dossier
Boehringer Ingelheim Pharma GmbH & Co. KG Binger Strasse 173 55216 Ingelheim am Rhein Germany Germany Active (2S,3S)-2,3-dihydroxysuccinic acid - 2-[(3R)-piperidin-3-yl]-1H-isoindole-1,3(2H)-dione (1:1) 692-713-4 886588-62-1 2016; 2019 View substance registered dossier
AGC Pharma Chemicals Europe, S.L.U. Camí de la Pomereda, 13 08380 Malgrat de Mar (Barcelona) Spain Spain Active (2S,3S)-2,3-dihydroxysuccinic acid - 2-[(3R)-piperidin-3-yl]-1H-isoindole-1,3(2H)-dione (1:1) 692-713-4 886588-62-1 - View substance registered dossier
Zoetis Belgium S.A. Rue Laid Burniat, 1 1348 Louvain-La-Neuve Belgium Belgium Active (2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine 831-973-7 147116-67-4 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant French competent national authority. - - Active (2S,3S)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylammonium methanesulfonate 425-530-3 98769-75-6 - View substance registered dossier
Sterling Pharma Solutions Ltd Dudley NE23 7QG Cramlington Northumberland United Kingdom United Kingdom No longer Valid (2S,3S)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylammonium methanesulfonate 425-530-3 98769-75-6 2021 View substance registered dossier
Envigo Consulting Limited Woolley Road Alconbury PE28 4HS Huntingdon Cambridgeshire United Kingdom United Kingdom No longer Valid (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride 478-270-8 - 2021 View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Cease Manufacture (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride 478-270-8 - 2019 View substance registered dossier
Envigo Consulting Limited Woolley Road Alconbury PE28 4HS Huntingdon Cambridgeshire United Kingdom United Kingdom No longer Valid (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride 478-270-8 - 2021 View substance registered dossier
OLON Spa Strada Rivoltana Km 6/7 20053 RODANO Milano Italy Italy Active (2S,3S)-di-tert-butyl 3-ethyl-4-oxopyrrolidine-1,2-dicarboxylate 942-044-1 - 2017 View substance registered dossier
Novartis Integrated Services Limited Ringaskiddy P43 FR63 Ringaskiddy Co. Cork Ireland Ireland Active (2S,3S,3aR,9aS)-3-hydroxy-2-(hydroxymethyl)-7-methyl-2,3,3a,9a-tertryhydro-6H-furo[2’,3’:4,5][1,3]oxazolo [3,2-a]pyrimidin-6-one 700-330-1 433733-92-7 2008; 2010; 2019 View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active (2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate 917-270-9 29790-50-9 - View substance registered dossier
[Confidential] - - - (2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate 917-270-9 29790-50-9 - View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Active (2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate 917-270-9 29790-50-9 2020 View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active (2S,3S,4R)-2-aminooctadecane-1,3,4-triol 439-210-6 554-62-1 - View substance registered dossier
[Confidential] - - - (2S,3S,4R)-2-aminooctadecane-1,3,4-triol 439-210-6 554-62-1 - View substance registered dossier
SCC Scientific Consulting Company GmbH Am Grenzgraben 11 55545 Bad Kreuznach Germany Germany Active (2S,3S,4R)-2-aminooctadecane-1,3,4-triol 439-210-6 554-62-1 2022 View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Active (2S,3S,4R)-2-aminooctadecane-1,3,4-triol 439-210-6 554-62-1 2011 View substance registered dossier
Gilead Sciences Ireland UC IDA Business &Technology Park Carrigtohill Cork Cork Ireland Ireland Active (2S,3S,4R)-3-ethyl-4-hydroxy-2-(methoxycarbonyl)pyrrolidinium 4-methylbenzenesulfonate 813-641-3 1799733-43-9 - View substance registered dossier
OLON Spa Strada Rivoltana Km 6/7 20053 RODANO Milano Italy Italy Active (2S,3S,4R)-methyl 4-((3-(1,1-difluorobut-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-3-ethylpyrrolidine-2-carboxylate 4-methylbenzenesulfonate 942-021-6 1799733-71-3 - View substance registered dossier
Gilead Sciences Ireland UC IDA Business &Technology Park Carrigtohill Cork Cork Ireland Ireland Active (2S,3S,4R)-methyl 4-((3-(1,1-difluorobut-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-3-ethylpyrrolidine-2-carboxylate 4-methylbenzenesulfonate 942-021-6 1799733-71-3 - View substance registered dossier
Esteve Quimica, S.A. Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain Spain Active (2S,3S,4R)-methyl 4-((3-(1,1-difluorobut-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-3-ethylpyrrolidine-2-carboxylate 4-methylbenzenesulfonate 942-021-6 1799733-71-3 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Cease Manufacture (2S,3S,5R)-2-hexyl-3-hydroxy-5-(phenylmethoxy)-Hexadecanoic acid compd. with (S)-α-methylbenzenemethanamine (1:1) 604-018-5 137433-01-3 2015 View substance registered dossier
Patheon Austria GmbH & Co KG St. Peter Strasse 25 4020 Linz Austria Austria Cease Manufacture (2S,3S,5R)-2-hexyl-3-hydroxy-5-(phenylmethoxy)-Hexadecanoic acid compd. with (S)-α-methylbenzenemethanamine (1:1) 604-018-5 137433-01-3 2020 View substance registered dossier
FRESENIUS KABI iPSUM s.r.l. Via Roma, 108 20060 Cassina de' Pecchi (MI) Italy Italy Active (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide 618-303-7 89786-04-9 - View substance registered dossier
IBI - Istituto Biochimico Italiano Giovanni Lorenzini Spa Via Fossignano, 2 04011 Aprilia (LT) Italy Italy Active (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide 618-303-7 89786-04-9 - View substance registered dossier
AbbVie Srl S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy Italy Active (2S,3S,5S)-5-amino-2-(dibenzylamino)-1,6-diphenylhexan-3-ol succinate 938-481-2 - - View substance registered dossier
Symrise AG Mühlenfeldstraße 1 37603 Holzminden Germany Germany Active (2S,4aR)-1,1,5,5-tetramethyl-1,3,4,5,6,7-hexahydro-2H-2,4a-methanonaphthalen-7-ol 942-036-8 645413-57-6 2020 View substance registered dossier
Corden Pharma Latina S.p.A. Via Murillo, 7 IT04013 Sermoneta (LT) Lazio Italy Italy Cease Manufacture (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester 411-020-8 - 2017 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Italian competent national authority. - - Active (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester 411-020-8 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester 411-020-8 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester 411-020-8 - - View substance registered dossier
Symrise AG Mühlenfeldstraße 1 37603 Holzminden Germany Germany Active (2S,4R)-1-hexadecanoyl-4-hydroxy-pyrrolidine-2-carboxylic acid 944-347-4 - - View substance registered dossier
Flamma S.p.a. via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy Italy Active (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 604-011-7 13726-69-7 - View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 604-011-7 13726-69-7 2019; 2022 View substance registered dossier
Lundbeck Pharmaceuticals Italy S.p.A via quarta strada 2 35129 padova Italy Italy Active (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 604-011-7 13726-69-7 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S,4S) 4-Hydroxymethyl-pyrrolidine-1,2-dicarboxylic acid 1-butyl ester 2-methyl ester 807-618-7 1194059-42-1 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S,4S)-1-(tert-butoxycarbonyl)-4-(hydroxymethyl)pyrrolidine-2-carboxylic acid 812-482-7 1643468-66-9 - View substance registered dossier
Gilead Sciences Ireland UC IDA Business &Technology Park Carrigtohill Cork Cork Ireland Ireland Active (2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carboxylic acid 807-416-9 1378388-16-9 - View substance registered dossier
Derivados Químicos S.A. Camino de Pliego, 150 30820 Alcantarilla Murcia Spain Spain Active (2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carboxylic acid 807-416-9 1378388-16-9 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carboxylic acid 807-416-9 1378388-16-9 - View substance registered dossier
AbbVie Srl S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy Italy Active (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one 423-090-7 156732-13-7 2011; 2018 View substance registered dossier
ITELYUM Purification S.P.A. Via S. Intini n. 2 27015 Landriano (PV) Italy Italy Active (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one 423-090-7 156732-13-7 2014 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one 423-090-7 156732-13-7 - View substance registered dossier
POLPHARMA 19 Pelplińska 83-200 Starogard Gdański Poland Poland Cease Manufacture (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one 423-090-7 156732-13-7 2022 View substance registered dossier
Curia Italy S.r.l. VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy Italy Active (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one 423-090-7 156732-13-7 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Italian competent national authority. - - Active (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one 423-090-7 156732-13-7 - View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Active (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxamide 812-263-6 1416134-49-0 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide 427-200-4 76646-91-8 - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X3336 Ringaskiddy Cork Ireland Ireland Active (2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide 427-200-4 76646-91-8 - View substance registered dossier
ACS DOBFAR S.p.A Viale Addetta 4/12 20067 Tribiano Milano Italy Italy Active (2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide 427-200-4 76646-91-8 - View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Active (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 812-287-7 1192651-49-2 - View substance registered dossier
Gilead Sciences Ireland UC IDA Business &Technology Park Carrigtohill Cork Cork Ireland Ireland Active (2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid 811-415-9 1335316-40-9 - View substance registered dossier
Flamma S.p.a. via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy Italy Active (2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid 811-415-9 1335316-40-9 2018 View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 255-799-0 42399-49-5 2018 View substance registered dossier
Cambrex Profarmaco Milano Srl via Curiel, 34 20067 Paullo MI Italy Italy Active (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 255-799-0 42399-49-5 - View substance registered dossier
LusoChimica S.p.A. Via Giotto, 9 23871 Lomagna (Lecco) Italy Italy Active (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 255-799-0 42399-49-5 - View substance registered dossier
Fermion Oy Koivu-Mankkaan tie 6 A FI-02101 Espoo Finland Finland Active (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 255-799-0 42399-49-5 2018 View substance registered dossier
INTEROR 49, rue d'Ostende F-62100 CALAIS France France Active (2S-cis)-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid 444-810-6 - 2014; 2021 View substance registered dossier
Zoetis Belgium S.A. Rue Laid Burniat, 1 1348 Louvain-La-Neuve Belgium Belgium Active (2S-cis)-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid 444-810-6 - - View substance registered dossier
FINORGA - MOURENX avenue du lac 64150 MOURENX France France Active (2S-cis)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 255-795-9 42399-40-6 - View substance registered dossier
Curia France SAS ZI de Laville 47240 BON-ENCONTRE France France Active (2S-trans)-3-amino-2-methyl-4-oxoazetidine-1-sulphonic acid 279-393-8 80082-65-1 - View substance registered dossier
Curia Italy S.r.l. VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy Italy Active (2S-trans)-3-amino-2-methyl-4-oxoazetidine-1-sulphonic acid 279-393-8 80082-65-1 - View substance registered dossier
Corden Pharma Latina S.p.A. Via Murillo, 7 IT04013 Sermoneta (LT) Lazio Italy Italy Active (2S-trans)-3-amino-2-methyl-4-oxoazetidine-1-sulphonic acid 279-393-8 80082-65-1 - View substance registered dossier
CHEMSAFE srl on behalf of AZO INTERNATIONAL CHEMICAL ltd Via Ribes, 5 10010 Colleretto Giacosa TO Italy Italy Active (2Z)-(5-amino-1,2,4-thiadiazol-3-yl)(ethoxyimino)acetic acid 616-178-3 75028-24-9 - View substance registered dossier
Fine and Performance Chemicals Ltd Skutterskelfe TS15 0JR Hutton Rudby North Yorkshire United Kingdom United Kingdom No longer Valid (2Z)-(5-amino-1,2,4-thiadiazol-3-yl)(ethoxyimino)acetic acid 616-178-3 75028-24-9 2021 View substance registered dossier
Chemours Netherlands B.V._3 Baanhoekweg 22 3313 LA Dordrecht Netherlands Netherlands Cease Manufacture (2Z)-1,1,1,4,4,4-hexafluorobut-2-ene 700-651-7 692-49-9 2021 View substance registered dossier
Chemours Netherlands B.V. Baanhoekweg 22 3313 LA Dordrecht Netherlands Netherlands Active (2Z)-1,1,1,4,4,4-hexafluorobut-2-ene 700-651-7 692-49-9 2014; 2015; 2019 View substance registered dossier
ACS DOBFAR S.p.A Viale Addetta 4/12 20067 Tribiano Milano Italy Italy Active (2Z)-2-(2-{[(benzyloxy)carbonyl]amino}-1,3-thiazol-4-yl)-5-[(3-methylbut-2-en-1-yl)oxy]-5-oxopent-2-enoic acid 889-755-2 102199-30-4 - View substance registered dossier
ACS DOBFAR S.p.A Viale Addetta 4/12 20067 Tribiano Milano Italy Italy Active (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[2-methyl-1-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]oxyiminoacetic acid 616-285-5 76028-96-1 - View substance registered dossier
ChemLeader 11 Fine & Performance Chemicals Ltd Długosza 67 43-188 Orzesze Poland Poland Active (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[2-methyl-1-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]oxyiminoacetic acid 616-285-5 76028-96-1 - View substance registered dossier
Corden Pharma Latina S.p.A. Via Murillo, 7 IT04013 Sermoneta (LT) Lazio Italy Italy Active (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[2-methyl-1-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]oxyiminoacetic acid 616-285-5 76028-96-1 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2Z)-2-chloro-3-(dimethylamino)-N,N-dimethylprop-2-en-1-iminium hexafluorophosphate 619-785-1 249561-98-6 - View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany Germany Active (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal 813-789-9 152873-67-1 2020 View substance registered dossier
Minakem Dunkerque Production 224 avenue de la Dordogne Zone d'entreprises du Nord Gracht 59640 DUNKERQUE France France Active (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal 813-789-9 152873-67-1 - View substance registered dossier
MINAKEM Beuvry Production SAS 145, Chemin des Lilas 59310 Beuvry-la-Forêt France France Active (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal 813-789-9 152873-67-1 - View substance registered dossier
PMC ISOCHEM 32 rue Lavoisier 91710 VERT LE PETIT France France Active (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal 813-789-9 152873-67-1 - View substance registered dossier
Evotec DS Germany GmbH Kantstrasse 2 33790 Halle/ Westf. Germany Germany Active (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal 813-789-9 152873-67-1 - View substance registered dossier
FIRMENICH GRASSE SAS OR 2 Parc Industriel Les Bois de Grasse 06130 Grasse France France Active (2Z)-2-phenylhex-2-enenitrile 482-160-5 130786-09-3 2020; 2022 View substance registered dossier
FIRMENICH GRASSE SAS OR 1 Parc Industriel Les Bois de Grasse 06130 Grasse France France Active (2Z)-2-phenylhex-2-enenitrile 482-160-5 130786-09-3 2020 View substance registered dossier
IFF Benicarlo, S.L. Avda. Felipe Klein 2 12580 Benicarlo Castellon Spain Spain Active (2Z)-2-phenylhex-2-enenitrile 482-160-5 130786-09-3 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (2Z)-2-phenylhex-2-enenitrile 482-160-5 130786-09-3 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2Z)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)but-2-en-1-one 616-378-0 767340-03-4 - View substance registered dossier
FIRMENICH GRASSE SAS OR 1 Parc Industriel Les Bois de Grasse 06130 Grasse France France Active (2Z)-4,8-dimethylnona-2,7-dien-4-ol 807-754-7 89929-57-7 2022 View substance registered dossier
ACS DOBFAR S.p.A Viale Addetta 4/12 20067 Tribiano Milano Italy Italy Active (2Z)-7-chloro-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid 618-065-4 877674-77-6 - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active (2Z)-but-2-ene-1,4-diyl diacetate 607-674-0 25260-60-0 2012; 2019 View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Cease Manufacture (2Z)-but-2-ene-1,4-diyl diacetate 607-674-0 25260-60-0 2020 View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.