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EC number: 949-740-4 | CAS number: -
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 December 2018 to 07 January 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of Inspection: 21 August 2018 Date of Issue: 19 November 2018
- Type of method:
- effusion method: vapour pressure balance
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0.002 Pa
- Conclusions:
- The vapour pressure of the test item has been determined to be 0.00179 Pa at 25°C.
- Executive summary:
The vapour pressure of the test item has been determined to be 0.00179 Pa at 25°C, using the vapour pressure balance method, designed to be compatible with Method A.4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.
Reference
Recorded temperatures, mass differences, and the resulting calculated values of vapour pressure are shown in the following tables:
Run 6
Table 1 - Vapour Pressure Data
Temperature (°C) |
Temperature (K) |
Reciprocal Temperature (K-1) |
Mass Difference (µg) |
Mass Difference (kg) |
Vapour Pressure (Pa) |
Log10Vp |
20 |
293.15 |
0.003411 |
1.06 |
1.060e-09 |
0.00147 |
-2.83268 |
21 |
294.15 |
0.003400 |
1.20 |
1.200e-09 |
0.00167 |
-2.77728 |
22 |
295.15 |
0.003388 |
0.73 |
7.300e-10 |
0.00101 |
-2.99568 |
23 |
296.15 |
0.003377 |
1.36 |
1.360e-09 |
0.00189 |
-2.72354 |
24 |
297.15 |
0.003365 |
1.68 |
1.680e-09 |
0.00233 |
-2.63264 |
25 |
298.15 |
0.003354 |
1.47 |
1.470e-09 |
0.00204 |
-2.69037 |
26 |
299.15 |
0.003343 |
2.14 |
2.140e-09 |
0.00297 |
-2.52724 |
27 |
300.15 |
0.003332 |
2.03 |
2.030e-09 |
0.00282 |
-2.54975 |
28 |
301.15 |
0.003321 |
1.30 |
1.300e-09 |
0.00180 |
-2.74473 |
29 |
302.15 |
0.003310 |
1.16 |
1.160e-09 |
0.00161 |
-2.79317 |
30 |
303.15 |
0.003299 |
2.21 |
2.210e-09 |
0.00307 |
-2.51286 |
A plot of Log10 (Vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 6 gives the following statistical data using an unweighed least squares treatment.
Slope: -2230
Standard error in slope: 1080
Intercept: 4.78
Standard error in intercept: 3.62
The results obtained indicate the following vapour pressure relationship:
Log10(Vp(Pa)) = [-2230/temp(K)] + 4.78
The above yields a vapour pressure (Pa) at 298.15K with a common logarithm of -2.71.
Run 7
Table 2 - Vapour Pressure Data
Temperature (°C) |
Temperature (K) |
Reciprocal Temperature (K-1) |
Mass Difference (µg) |
Mass Difference (kg) |
Vapour Pressure (Pa) |
Log10Vp |
20 |
293.15 |
0.003411 |
0.78 |
7.800e-10 |
0.00108 |
-2.96658 |
21 |
294.15 |
0.003400 |
0.56 |
5.600e-10 |
0.00078 |
-3.10791 |
22 |
295.15 |
0.003388 |
1.03 |
1.030e-09 |
0.00143 |
-2.84466 |
23 |
296.15 |
0.003377 |
1.18 |
1.180e-09 |
0.00164 |
-2.78516 |
24 |
297.15 |
0.003365 |
1.99 |
1.990e-09 |
0.00276 |
-2.55909 |
25 |
298.15 |
0.003354 |
1.16 |
1.160e-09 |
0.00161 |
-2.79317 |
26 |
299.15 |
0.003343 |
1.34 |
1.340e-09 |
0.00186 |
-2.73049 |
27 |
300.15 |
0.003332 |
1.07 |
1.070e-09 |
0.00149 |
-2.82681 |
28 |
301.15 |
0.003321 |
1.43 |
1.430e-09 |
0.00199 |
-2.70115 |
29 |
302.15 |
0.003310 |
2.35 |
2.350e-09 |
0.00326 |
-2.48678 |
30 |
303.15 |
0.003299 |
1.71 |
1.710e-09 |
0.00237 |
-2.62525 |
A plot of Log10 (Vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 7 gives the following statistical data using an unweighed least squares treatment.
Slope: -3560
Standard error in slope: 1060
Intercept: 9.18
Standard error in intercept: 3.55
The results obtained indicate the following vapour pressure relationship:
Log10(Vp(Pa)) = [-3560/temp(K)] + 9.18
The above yields a vapour pressure (Pa) at 298.15K with a common logarithm of -2.76.
Run 8
Table 3 - Vapour Pressure Data
Temperature (°C) |
Temperature (K) |
Reciprocal Temperature (K-1) |
Mass Difference (µg) |
Mass Difference (kg) |
Vapour Pressure (Pa) |
Log10Vp |
20 |
293.15 |
0.003411 |
1.05 |
1.050e-09 |
0.00146 |
-2.83565 |
21 |
294.15 |
0.003400 |
0.80 |
8.000e-10 |
0.00111 |
-2.95468 |
22 |
295.15 |
0.003388 |
0.68 |
6.800e-10 |
0.00094 |
-3.02687 |
23 |
296.15 |
0.003377 |
1.06 |
1.060e-09 |
0.00147 |
-2.83268 |
24 |
297.15 |
0.003365 |
1.01 |
1.010e-09 |
0.00140 |
-2.85387 |
25 |
298.15 |
0.003354 |
0.77 |
7.700e-10 |
0.00107 |
-2.97062 |
26 |
299.15 |
0.003343 |
1.85 |
1.850e-09 |
0.00257 |
-2.59007 |
27 |
300.15 |
0.003332 |
2.28 |
2.280e-09 |
0.00317 |
-2.49894 |
28 |
301.15 |
0.003321 |
2.05 |
2.050e-09 |
0.00285 |
-2.54516 |
29 |
302.15 |
0.003310 |
1.99 |
1.990e-09 |
0.00276 |
-2.55909 |
30 |
303.15 |
0.003299 |
1.73 |
1.730e-09 |
0.00240 |
-2.61979 |
A plot of Log10 (Vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 8 gives the following statistical data using an unweighed least squares treatment.
Slope: -4080
Standard error in slope: 1008
Intercept: 10.9
Standard error in intercept: 3.64
The results obtained indicate the following vapour pressure relationship:
Log10(Vp(Pa)) = [-4080/temp(K)] + 10.9
The above yields a vapour pressure (Pa) at 298.15K with a common logarithm of -2.75.
Run 10
Table 4 - Vapour Pressure Data
Temperature (°C) |
Temperature (K) |
Reciprocal Temperature (K-1) |
Mass Difference (µg) |
Mass Difference (kg) |
Vapour Pressure (Pa) |
Log10Vp |
20 |
293.15 |
0.003411 |
0.43 |
4.300e-10 |
0.00060 |
-3.22185 |
21 |
294.15 |
0.003400 |
0.71 |
7.100e-10 |
0.00099 |
-3.00436 |
22 |
295.15 |
0.003388 |
0.90 |
9.000e-10 |
0.00125 |
-2.90309 |
23 |
296.15 |
0.003377 |
0.97 |
9.700e-10 |
0.00135 |
-2.86967 |
24 |
297.15 |
0.003365 |
1.40 |
1.400e-09 |
0.00194 |
-2.71220 |
25 |
298.15 |
0.003354 |
1.50 |
1.500e-09 |
0.00208 |
-2.68194 |
26 |
299.15 |
0.003343 |
1.13 |
1.130e-09 |
0.00157 |
-2.80410 |
27 |
300.15 |
0.003332 |
2.10 |
2.100e-09 |
0.00292 |
-2.53462 |
28 |
301.15 |
0.003321 |
1.95 |
1.950e-09 |
0.00271 |
-2.56703 |
29 |
302.15 |
0.003310 |
2.07 |
2.070e-09 |
0.00287 |
-2.54212 |
30 |
303.15 |
0.003299 |
1.63 |
1.630e-09 |
0.00226 |
-2.64589 |
A plot of Log10 (Vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 10 gives the following statistical data using an unweighed least squares treatment.
Slope: -5140
Standard error in slope: 886
Intercept: 14.5
Standard error in intercept: 2.97
The results obtained indicate the following vapour pressure relationship:
Log10(Vp(Pa)) = [-5140/temp(K)] + 14.5
The above yields a vapour pressure (Pa) at 298.15K with a common logarithm of -2.77.
The values of vapour presure at 25°C, extrapolated from each graph, are summarised in the following table:
Table 5 Summary of Vapour Pressure Data
Run |
Log10[Vp(25°C)] |
6 |
-2.71 |
7 |
-2.76 |
8 |
-2.75 |
10 |
-2.77 |
Mean |
-2.75 |
Vapour Pressure |
0.00179 Pa |
The test item did not change in appearance under the conditions used in the determination.
A total of 10 runs were completed for the main sequence. Equilibrium with regard to vapour pressure has been assessed to have been reached over the final 4 runs (run 9 was not used due to a highly erroneous plot being obtained); thus the final 4 runs have been used to calculate the vapour pressure. The reported runs are on the limits of accuracy with regard to the mass difference obtained, any further runs on the sample would led to a less accurate limit value being imposed on the data.
The results may represent rounded values obtained by calculations based on the exact raw data.
Description of key information
0.00179 Pa at 25°C; OECD 104; Ford, A.J. (2019)
Key value for chemical safety assessment
- Vapour pressure:
- 0.002 Pa
- at the temperature of:
- 25 °C
Additional information
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