Registration Dossier
Registration Dossier
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EC number: 610-790-4 | CAS number: 52169-36-5
Guidance on Safe Use
Administrative data
First-aid measures
INHALATION
Description of first aid measures: remove the injured from the contaminated zone. If necessary, give oxygen and take the injured to the hospital.
Most important symptoms and effects, both acute and delayed: cough, breathing problem (bronchospasm).
CONTACT WITH THE SKIN
Description of first aid measures: In case of skin contact, remove all contaminated clothing and shoes and wash the skin with copious amount of water and soap. Contact a dermatologist/physician if necessary
Most important symptoms and effects, both acute and delayed: reddening with itching, irritation.
CONTACT WITH THE EYES
Description of first aid measures: in case of contact with eyes flush immediately with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. If the symptoms persist, contact an ophthalmologist or physician.
Most important symptoms and effects, both acute and delayed: burning sensation.
INGESTION
Description of first aid measures: if a great quantity of the product has been ingested, give fruit juice or activated carbon to cause emesis and then bring urgently the person injured to the hospital.
Most important symptoms and effects, both acute and delayed: abdominal pain, gastric disorders, hepatic alteration, nausea.
INDICATION OF ANY IMMEDIATE MEDICAL ATTENTION AND SPECIAL TREATMENT NEEDED
Overdosage of sulfonylureas, including glyburide, can produce hypoglycemia. Mild hypoglycemic symptoms, without loss of consciousness or neurological findings, should be treated aggressively with oral glucose and adjustments in drug dosage and/or meal patterns. Close monitoring should continue until the physician is assured that the patient is out of danger. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization. If hypoglycemic coma is diagnosed or suspected, the patient should be given a rapid intravenous injection of concentrated (50 %) glucose solution. This should be followed by a continuous infusion of a more dilute (10 %) glucose solution at a rate which will maintain the blood glucose at a level above 100 mg/dl. Patients should be closely monitored for a minimum of 24 to 48 hours, since hypoglycemia may recur after apparent clinical recovery.
Fire-fighting measures
EXTINGUISHING MEDIA
- SUITABLE: dry chemical powder, carbon dioxide or appropriate foams.
- UNSUITABLE: water may be ineffective in firefighting due to low solubility.
SPECIAL HAZARDS ARISING FROM THE SUBSTANCE OR MIXTURE
The thermal decomposition of the product may produce toxic fumes and cause intoxication. Hazardous decomposition or combustion products: Carbon monoxide, carbon dioxide and nitrogen oxides NOx and sulphur oxides SOX. Hydrogen halides may be formed.
ADVICE FOR FIREFIGHTERS
For single units (packages): no special requirements needed.
For larger amounts (multiple packages/pallets) of product: since toxic, corrosive or flammable vapours might be evolved from fires involving the product and associated packaging, self contained breathing apparatus a full protective equipment are recommended for fire fighters. (Full facial mask with “Universal” filter). If possible, contain and collect fire fighting water for later disposal.
Accidental release measures
PERSONAL PRECAUTIONS, PROTECTIVE EQUIPMENT AND EMERGENCY PROCEDURES
Prevention of skin and eye contact and personal clothing: wear protective clothing, protective glasses, rubber boots and heavy-duty rubber gloves.
Provision for sufficient ventilation/ respiratory protection: wear an independent respirator. Evacuate the area and aerate the zone contaminated by the spilt product after cleaning it away completely.
Control of dust: avoid forming clouds of dust/powder.
ENVIRONMENTAL PRECAUTIONS
Do not allow the product to enter water or the soil. Prevent it from entering the drains or sewers. Use suitable containers for preventing environmental pollution. Alert neighbourhood, not necessary.
METHODS AND MATERIAL FOR CONTAINMENT AND CLEANING UP
Use of absorbent material: vermiculite, dry sand, earth.
Cleaning methods: immediately contact emergency personnel. Evacuate and ventilate area. Wear appropriate personal protective equipment. Clean up spills or leak immediately. Wash the contaminated area with water or diluted alkaline solutions then absorb with a inert material (vermiculite, dry sand, earth, etc) and place in a closed chemical waste container for disposal.
Handling and storage
PRECAUTIONS FOR SAFE HANDLING
Containment, local and general ventilation, measures to prevent aerosol and dust generation and fire.
The premises set up for the handling of the product must be fitted out with localised and controlled aeration systems (laminar flow hoods, etc.) capable of confining the dispersion of the active ingredient in the form of air-dispersed powder. Use hoods with interchangeable filters.
Advice on general occupational hygiene: use suitable personal protection devices including certified respirators, protective safety glasses and compatible gloves resistant against chemical agents. Wash yourself with care after each handling operation. Never eat, drink or smoke during handling. Safety shower and washing stations for rinsing eyes must be provided.
CONDITIONS FOR SAFE STORAGE, INCLUDING ANY INCOMPATIBILITIES
Specific storage requirements to control of the environmental effects: store in a cool, dry, well ventilated area.
Type of materials used in packing/containers of substance: pack the product in double polythene bags, individually sealed and store in cardboard bins fitted with an aluminium safety locking ring.
Transport information
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
EYE/ FACE PROTECTION: wear protective glasses (EN 166) during the execution of any industrial type of operations. If necessary, wear a protective face shield.
SKIN PROTECTION: use work overalls and/or coat, or dustproof overalls in Tyvek with hood for industrial type operations.
HAND PROTECTION: wear nitrile or rubber gloves (neoprene). Minimum thickness of gloves: 0.11 mm. Permeability is not anticipated with dry solid substances and therefore the duration of the protective gloves has not been calculated. The selected protective gloves have to satisfy the specifications of the EU Directive 89/686/EEC and the standard EN 374 derived from it.
RESPIRATORY PROTECTION
For nuisance exposures use FFP1 dustproof mask or type P95 (US) or type P1 (EU EN 143) particle respirator. For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Stability and reactivity
POSSIBILITY OF HAZARDOUS REACTIONS: no hazardous polymerisations occur.
CONDITIONS TO AVOID: heat over decomposition temperature.
INCOMPATIBLE MATERIALS: strong oxidising agents.
HAZARDOUS DECOMPOSITION PRODUCTS: the thermical decomposition or ignition can produce fumes COx, SOx, NOx and HCl.
Disposal considerations
INCINERATION: dissolve or mix the product with a combustible solvent then incinerate in an incinerator for chemical products equipped with a post-combustion and destruction system.
DISPOSAL METHODS SUITABLE FOR THE SUBSTANCE: this material and its containers must be disposed of as hazardous waste products.
SUITABLE DISPOSAL METHODS FOR COMBINED PACKAGING MATERIALS: the combined packaging materials must be disposed of as hazardous waste products.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
