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EC number: 263-423-1 | CAS number: 62125-22-8
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
Description of key information
The chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 does not indicate the need to investigate further the toxicity to terrestrial arthropods.
Key value for chemical safety assessment
Additional information
In accordance with Regulation (EC) No. 1907/2006, Annex IX, column 2, 9.4 further studies on the effects on terrestrial organisms do not have to be conducted since the chemical safety assessment indicates that there is no need. No experimental data on toxicity to terrestrial arthropods are available for2,2-bis[[(1-oxoisooctadecyl)oxy]methyl]-1,3-propanediyl bis(isooctadecanoate) (CAS 62125-22-8).The test substance is characterized by a high log Koc indication a considerable potential for adsorption to the soil particles. Therefore, tests with soil-dwelling organisms that feed on soil particles are most relevant for the evaluation of soil toxicity of the test substance.
Since the substance is readily biodegradable, a chronic exposure of terrestrial organisms is not likely. Nevertheless, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances and read-across, a read-across to three structurally related category members 2,2-bis(hydroxymethyl)-1,3-propanediyl dioleate (CAS 25151-96-6), fatty acids, C16-18 and C18-unsaturated, esters with pentaerythritol (CAS 85711-45-1) and fatty acids, C16-18 and C18-unsatd., tetraesters with pentaerythritol (CAS 68604-44-4) was made in order to assess chronic exposure. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance within this category was used.The read-across substances used for the assessment of chronic exposure exhibit longer fatty acid chain lengths (≥ C16) as the target substance and are mono- to tetra-esters. Due to the high adsorption potential with the longer fatty acid chains, these substances represent a worst case for the uptake via ingestion of soil bounded particles within the group. Chronic tests with the group members 2,2-bis(hydroxymethyl)-1,3-propanediyl dioleate (CAS 25151-96-6), fatty acids, C16-18 and C18-unsaturated, esters with pentaerythritol (CAS 85711-45-1) and fatty acids, C16-18 and C18-unsatd., tetraesters with pentaerythritol (CAS 68604-44-4) were conducted according to OECD 222 under GLP conditions. No mortality or effects on reproduction of earthworms up to 1000 mg/kg dw soil occurred in any of these three tests.
Additionally, an acute test according to OECD 207 with the read-across substance decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) did not result in any mortalities in the treatment group exposed to 1000 mg/kg dw soil. The test substance represents the lower end of the group (C5-C10 fatty acid chain length) and is assumed to represent worst case in terms of absorption via pore water (for details please refer to the overall summary, IUCLID chapter 6.3).
Moreover, a chronic toxicity test with aquatic invertebrates is conducted with the read-across substance decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS No. 71010-76-9).The read-across substance is covering the variability of the group with shorter fatty acid chain lengths (C5-C10). Both substances, the read-across as well as the target substance, contain the same alcohol and are tetra-esters.The read-across substance did not show any chronic effects up to the limit of water solubility on the water flea Daphnia magna in a GLP study according to OECD 211. In addition, a chronic test with aquatic invertebrates with another read across-substance, fatty acids, C16-18 and C18-unsaturated, esters with pentaerythritol (CAS 85711-45-1) is available resulting in no effects up to the water solubility of the read-across substance. This read-across substance as well as the target substance belongs to the other end of the group with longer fatty acid chains (≥ C16).
Based on these information, toxicity to terrestrial arthropods is not expected to be of concern, and consequently, no further testing is required.
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