Climbazole

Short-term toxicity to aquatic invertebrates

Description of key information

The short-term toxicity of the test substance to freshwater invertebrates was investigated with Daphnia magna according to OECD 202.

The EC50(48h) is 10.9 mg/L based on measured concentrations.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

10.9 mg/L

Additional information

Based on a Weight of Evidence approach with Daphnia magna studies, the endpoint short-term toxicity to aquatic invertebrates is covered.

The first study (1990) was done according to a draft guideline of the German Federal Environmental Agency (Umweltbundesamt) from 1984. Daphnia magna were exposed to 3.1, 6.25, 12.5, 25, 50 and 100 mg/L of the test substance for 24 hours. The EC0 based on nominal concentrations was determined to be 12.5 mg/L and the LC100 to be 50 mg/L. The geometric mean (EC0/EC100) of these to values is 25 mg/L and used as EC50 estimation. Due to the test duration of only 24 hours this test is not reliable (RL3) on its own.

In a second study, that was recently published in a peer reviewed journal (Richter et al, 2013), Daphnia magna were exposed to concentrations of 1.88 to 30 mg/L for 48 hours according to OECD 202. The EC50 (48h) based on measured concentrations was determined to be 10.9 mg/L. Due to the limited details mentioned in the publication a reliability cannot be assigned (RL4), but is expected to be reliable based on the existing raw data.

Furthermore no immobility of Daphnia magna was observed in the long-term study according to OECD 211 at concentrations up to 0.8 mg/L.

Based on these information, it is clear that invertebrates are not the most sensitive species and no further acute tests are necessary to cover this endpoint. Data on marine aquatic invertebrates are not available.