Registration Dossier
Registration Dossier
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EC number: 225-897-8 | CAS number: 5137-70-2
Endpoint summary
Administrative data
Description of key information
For skin irriration, one study on an analogue was available (Reliabilty 2 (Allen, 1997)
No study available for eye irritation
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation / Corrosion
In the study of Allen (Key study, 1997), exposure of one rabbit for 1 or 2 hours produced severe erythema (grade 4) and oedema (grade 3) at 24 hours. Effects indicating dermal corrosion prevented evaluation of erythema or oedema at 48 and 72 hours. Effects persisted to termination of the study at 12 days.
Eye irritation.
As DodecylPhosphonic acid was considered to be corrosive to the skin, no study on eye was performed
Justification for selection of skin irritation / corrosion endpoint:
Only one study available on an analogue.
Effects on skin irritation/corrosion: corrosive
Justification for classification or non-classification
Skin:
Corrosive effects from 1, 2 or 4 hour exposures were not fully resolved by end of the 12 day observation period. No corrosive effects were reported for a 3-minute exposure. Based on these results on OPA, DodecylPhosphonic Acid is classified as Corrosive, Category 1B (H314: causes severe skin burns and eye damage) according to the criteria of the Regulation (EC) 1272/2008 and as skin corrosive (C-R34) according to the criteria of the Annex VI of the Directive 67/548/EEC.
Eye:
According to the criteria of the Regulation (EC) 1272 / 2008, DodecylPhosphonic Acid is classified as causing serious eye damage, category 1 (implicit in skin corrosion classification).
Respiratory System:
No classification is possible due to lack of data.
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