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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
toxicity to birds
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only a summary is provided.

Data source

Reference
Reference Type:
publication
Title:
The Acute Oral Toxicity, Repellency, and Hazard Potential of 998 Chemicals to One or More Species of Wild and Domestic Birds
Author:
Schafer, E.W., Bowles, W.A., Hurlbut, J.
Year:
1983
Bibliographic source:
Arch. Environm. Contam. Toxicol. 12, 355-382

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
other: DeCino, T. J., D. J. Cunningham, and E. W. Schafer: Toxicity of DRC-1339 to starlings. J. Wild!. Manage. 30, 249 (1966).
Qualifier:
according to guideline
Guideline:
other: Schafer, E. W., Jr.: The acute oral toxicity of 369 pesticidal, pharmaceutical and other chemicals to wild birds. Toxico!. App!. Pharmaco!. 21, 315 (1972).
Qualifier:
according to guideline
Guideline:
other: Thompson, W. R: Use of moving averages and interpolation to estimate median effective dose. Bacterio!. Rev. 11, 115 (1948).
Qualifier:
according to guideline
Guideline:
other: Thompson, W. R., and C. S. Weil: On the construction of tables for moving average interpolation. Biometrics 8, 51 (1952).
Qualifier:
according to guideline
Guideline:
other: Wei!, C. S.: Tables for convenient calculation of median effective dose (LDso or EDso) and instructions in their use. Biometrics 8, 249 (1952).
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trientine
EC Number:
203-950-6
EC Name:
Trientine
Cas Number:
112-24-3
Molecular formula:
C6H18N4
IUPAC Name:
N,N'-bis(2-aminoethyl)ethane-1,2-diamine

Results and discussion

Effect levels
Duration (if not single dose):
18 h
Dose descriptor:
LD50
Effect level:
> 110 mg/kg bw
Conc. / dose based on:
not specified
Basis for effect:
mortality

Applicant's summary and conclusion

Executive summary:

The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one or more of 68 species of wild and domestic birds was determined by standardized testing procedures. Redwinged blackbirds were the most sensitive of the bird species tested on a large number of chemicals, and an index based on redwing toxicity and repellency may provide an appropriate indication of the probability of acute avian poisoning episodes. Avian repellency and toxicity were not positively correlated (i.e. toxicity varied independently with repellency).

For triethylene tetraamine (CAS 112 -24 -3) the LD50 was estimated based on the food consumption measured over a period of 18 hours. The LD50 is estimated at 101 mg/kg.