EU-SAFETY_HEALTH_WORK-PREAMBLE

Safety and Health of Workers at Work Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 89/391/EEC, 29 June 1989, amended by Regulation 1137/2008/EC, 21 November 2008 (Table 3/Annex VI, CLP; Annex III, 2000/54/EC)

This list contains a non-exhaustive inventory of substances that fall within the scope of the European Union's definition of hazardous chemical and biological substances, as provided on: (1) Table 3 of Annex VI to the CLP Regulation 1272/2008/EC; and (2) Annex III of Directive 2000/54/EC (Biological Agents). The EU's Occupational Safety and Health (OSH) Framework Directive 89/391/EEC applies to risks arising from chemical, physical and biological agents at the workplace.

Last updated 26 April 2024. Database contains 4691 unique substances/entries.
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210-478-4
616-38-6
Flam. Liq. 2
620-379-1
3254-63-5
Acute Tox. 1; Acute Tox. 2
C.I. DISPERSE BLUE 356
400-460-6
118578-14-6
Skin Sens. 1
432-310-0
617-55-0
Flam. Liq. 3; Eye Dam. 1; Skin Sens. 1
404-200-2
110488-70-5
Repr. 1B
200-480-3
60-51-5
Acute Tox. 4
605-329-9
163515-14-8
Acute Tox. 4; Skin Sens. 1
256-625-6
50563-36-5
Acute Tox. 4; Skin Sens. 1
215-629-8
1335-31-5
Expl. 1.1; Acute Tox. 3; STOT RE 2
233-307-5
10112-91-1
Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
262-784-2
61432-55-1
Acute Tox. 4
204-076-8
115-26-4
Acute Tox. 1; Acute Tox. 2
BLUE GS 1259 R5
407-230-4
126637-70-5
Acute Tox. 4; Skin Sens. 1
REACTIVE ORANGE F-64 258 FW
401-010-1
106027-83-2
Skin Sens. 1
203-326-3
105-74-8
Org. Perox. D
211-617-1
674-82-8
Flam. Liq. 3; Acute Tox. 4
203-558-5
108-18-9
Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1B
203-560-6
108-20-3
Flam. Liq. 2; STOT SE 3
210-088-4
605-50-5
Repr. 1B
248-523-5
27554-26-3
Repr. 1B
276-090-2
71850-09-4
Repr. 1B
201-553-2
84-69-5
Repr. 1B
201-559-5
84-75-3
Repr. 1B
200-760-5
71-63-6
Acute Tox. 3; STOT RE 2
600-594-7
104653-34-1
Repr. 1B; Acute Tox. 1; STOT RE 1
601-613-1
119446-68-3
Carc. 2; Acute Tox. 4; Eye Irrit. 2
IRB
418-070-1
141714-54-7
Skin Sens. 1
209-161-3
557-20-0
Pyr. Liq. 1; Water-react. 1; Skin Corr. 1B
270-877-4
68479-98-1
Acute Tox. 4; STOT RE 2; Eye Irrit. 2
425-380-9
7397-46-8
Pyr. Liq. 1; Acute Tox. 4; STOT RE 2; Skin Corr. 1B; Skin Sens. 1
211-000-7
627-44-1
Acute Tox. 2; Acute Tox. 1; STOT RE 2
DIETHYLDIMETHYLAMMONIUMHYDROXIDE
419-400-5
95500-19-9
Acute Tox. 4; Skin Corr. 1A
201-798-5
88-10-8
Carc. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
203-716-3
109-89-7
Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1A
431-430-0
103976-28-9
Acute Tox. 4
CS 100; SILOXAL
401-160-8
55426-95-4
Water-react. 1; Pyr. Liq. 1; Skin Corr. 1A
DAMA
426-790-0
162208-27-7
Acute Tox. 4; STOT RE 2; Skin Sens. 1
200-589-6
64-67-5
Carc. 1B; Muta. 1B; Acute Tox. 4; Skin Corr. 1B
200-467-2
60-29-7
Flam. Liq. 1; Acute Tox. 4; STOT SE 3
SIFOSIL; SIFOSIL KONZENTRAT G 96-00 FEST
401-770-4
148324-78-1
Skin Corr. 1B; Acute Tox. 4
258-526-3
53404-23-2
Acute Tox. 4
274-460-8
70225-14-8
Carc. 2; Repr. 1B; STOT RE 1; Acute Tox. 4; Lact.
200-484-5
60-57-1
Carc. 2; Acute Tox. 1; Acute Tox. 3; STOT RE 1
230-525-2
7173-51-5
Acute Tox. 4; Skin Corr. 1B
DCPMS; DYNASYLAN 9415; EURENOR 5023; SAN-30; WACKER SILAN CP2-DIMETHOXY; Z-6228
404-370-8
126990-35-0
Skin Irrit. 2; Eye Dam. 1
208-704-1
538-75-0
Acute Tox. 3; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
221-515-9
3129-91-7
Acute Tox. 4
202-980-7
101-83-7
Acute Tox. 4; Skin Corr. 1B
201-545-9
84-61-7
Repr. 1B; Skin Sens. 1
205-494-3
141-66-2
Acute Tox. 2; Acute Tox. 3
200-632-9
66-76-2
STOT RE 1; Acute Tox. 4
215-270-7
1317-39-1
Acute Tox. 4; Eye Dam. 1
215-572-9
1332-65-6
Acute Tox. 4; Acute Tox. 3
204-082-0
115-32-2
Acute Tox. 4; Skin Irrit. 2; Skin Sens. 1
257-141-8
51338-27-3
Acute Tox. 4; Skin Sens. 1
620-436-0
75736-33-3
Eye Irrit. 2
246-356-2
24613-89-6
Ox. Sol. 1; Carc. 1B; Skin Corr. 1A; Skin Sens. 1
200-547-7
62-73-7
Acute Tox. 2; Acute Tox. 3; Skin Sens. 1
D-2,4-DP; DICHLORPROP-P; DUPLOSAN DP-ACID
403-980-1
15165-67-0
Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
204-390-5
120-36-5
Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
202-567-1
97-23-4
Acute Tox. 4; Eye Irrit. 2
200-838-9
75-09-2
Carc. 2
222-583-2
3542-36-7
Repr. 1B; Acute Tox. 2; STOT RE 1
620-404-6
7572-29-4
Unst. Expl.; Carc. 2; STOT RE 2
201-199-9
79-36-7
Skin Corr. 1A
201-207-0
79-43-6
Skin Corr. 1A
220-487-5
2782-57-2
Ox. Sol. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
SILAN DCS
407-180-3
770722-36-6
Skin Corr. 1A
204-210-5
117-80-6
Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2
214-118-7
1085-98-9
Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
202-564-5
97-17-6
Acute Tox. 4
214-787-5
1194-65-6
Acute Tox. 4
217-635-6
1918-00-9
Acute Tox. 4; Eye Dam. 1
212-449-1
818-08-6
Muta. 2; Repr. 1B; Acute Tox. 3; STOT RE 1; Skin Irrit. 2; Eye Dam. 1
201-077-5
78-04-6
Muta. 2; Repr. 1B; Acute Tox. 2; Acute Tox. 4; STOT RE 1; Skin Corr. 1; Eye Dam. 1
DBB
401-040-5
75113-37-0
Repr. 1B; Muta. 2; STOT RE 1; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
201-039-8
77-58-7
Muta. 2; Repr. 1B; STOT RE 1
211-670-0
683-18-1
Muta. 2; Repr. 1B; Acute Tox. 2; Acute Tox. 3; Acute Tox. 4; STOT RE 1; Skin Corr. 1B
213-928-8
1067-33-0
Muta. 2; Repr. 1B; STOT RE 1
220-481-2
2781-10-4
Muta. 2; Repr. 1B; STOT RE 1
245-152-0
22673-19-4
Repr. 1B; STOT RE 1
AMINODARONE OXALATE; SR33580A
448-700-9
500791-70-8
STOT RE 2; Eye Dam. 1; Skin Sens. 1
201-557-4
84-74-2
Repr. 1B
200-824-2
74-95-3
Acute Tox. 4
215-125-8
1303-86-2
Repr. 1B
ZK RT 1507
417-760-8
134164-24-2
STOT RE 1; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
202-327-6
94-36-0
Org. Perox. B; Eye Irrit. 2; Skin Sens. 1
205-886-4
191-30-0
Carc. 1B; Muta. 2
205-878-0
189-64-0
Carc. 1B; Muta. 2
200-181-8
53-70-3
Carc. 1B
206-382-7
334-88-3
Carc. 1B
206-373-8
333-41-5
Acute Tox. 4
215-481-4
1327-53-3
Carc. 1A; Acute Tox. 2; Skin Corr. 1B
215-116-9
1303-28-2
Carc. 1A; Acute Tox. 3
237-499-1
13820-41-2
Acute Tox. 3; Skin Irrit. 2; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
231-786-5
7727-54-0
Ox. Sol. 3; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
-
74195-78-1
Carc. 1A; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
239-793-5
15699-18-0
Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Acute Tox. 4; Resp. Sens. 1; Skin Sens. 1
240-973-0
16919-58-7
Acute Tox. 3; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
422-670-7
150202-11-2
Repr. 2; Acute Tox. 3; STOT RE 2
GENIPLEX A
401-610-3
122012-52-6
Acute Tox. 4; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
-
-
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 3; Acute Tox. 4; STOT RE 2; Eye Irrit. 2; Skin Sens. 1
234-454-8
12004-35-2
Carc. 1A; STOT RE 1; Skin Sens. 1
205-016-3
131-17-9
Acute Tox. 4
233-689-3
10311-84-9
Acute Tox. 2; Acute Tox. 3
203-733-6
110-05-4
Org. Perox. E; Flam. Liq. 2; Muta. 2
CM 26-137
406-052-4
125078-60-6
Flam. Liq. 3; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
205-017-9
131-18-0
Repr. 1B
DNOAI
408-190-0
7585-14-0
Pyr. Liq. 1; Skin Corr. 1B
203-921-8
111-92-2
Flam. Liq. 3; Acute Tox. 2; Acute Tox. 3; Skin Corr. 1B; Eye Dam. 1
205-575-3
142-96-1
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
204-697-4
124-40-3
Flam. Gas 1; Press. Gas; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
204-697-4
124-40-3
Flam. Liq. 1; Acute Tox. 4; Skin Corr. 1B
PINOLENE
417-870-6
83648-84-4
Skin Irrit. 2; Skin Sens. 1
686-814-2
34363-01-4
Skin Irrit. 2; Skin Sens. 1
218-961-1
2303-16-4
Carc. 2; Acute Tox. 4
DIRECT BLUE 199
416-180-2
12222-04-7
Acute Tox. 4; STOT RE 2
204-424-9
120-78-5
Skin Sens. 1
213-800-1
1014-69-3
Acute Tox. 4
237-198-5
13684-56-5
Repr. 2
-
-
V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
241-109-5
17040-19-6
Acute Tox. 3; Acute Tox. 4
213-052-6
919-86-8
Acute Tox. 3
204-801-8
126-75-0
Acute Tox. 1; Acute Tox. 2
212-758-1
867-27-6
Acute Tox. 3
206-053-8
298-03-3
Acute Tox. 1; Acute Tox. 2
620-378-6
8065-48-3
Acute Tox. 1; Acute Tox. 2
219-971-9
2587-90-8
Acute Tox. 2; Acute Tox. 3
211-666-9
682-80-4
Acute Tox. 2; Acute Tox. 3
258-256-6
52918-63-5
Acute Tox. 3
-
1563-67-3
Acute Tox. 3
206-376-4
334-48-5
Skin Irrit. 2; Eye Irrit. 2
200-024-3
50-29-3
Carc. 2; Acute Tox. 3; STOT RE 1
208-576-7
533-74-4
Acute Tox. 4; Eye Irrit. 2
201-248-4
80-08-0
Acute Tox. 4
216-485-9
1596-84-5
Carc. 2
200-923-0
75-99-0
Skin Irrit. 2; Eye Dam. 1
204-828-5
127-20-8
Skin Irrit. 2; Eye Dam. 1
432-960-5
124655-09-0
Acute Tox. 4
218-827-2
2244-16-8
Skin Sens. 1
DEM
408-120-9
65197-96-8
Acute Tox. 4; Eye Dam. 1
-
-
V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
274-050-9
69581-33-5
Acute Tox. 3; Acute Tox. 4
601-785-8
121552-61-2
Skin Sens. 1
619-020-1
94361-06-5
Repr. 1B; Acute Tox. 3; STOT RE 2
257-842-9
52315-07-8
Acute Tox. 4; STOT SE 3; STOT RE 2
257-842-9
52315-07-8
Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
261-043-0
57966-95-7
Repr. 2; Acute Tox. 4; STOT RE 2; Skin Sens. 1
236-049-1
13121-70-5
Acute Tox. 4
269-855-7
68359-37-5
Lact.; Acute Tox. 2; STOT SE 1
642-974-5
400882-07-7
Carc. 2; Skin Sens. 1A
405-230-9
101205-02-1
Repr. 2
-
-
P Parasites
200-847-8
75-19-4
Flam. Gas 1; Press. Gas
CHLOROFORMIATE DE CYCLOPENTYLE; CYCLOPENTYLCHLORFORMIAT
411-460-0
50715-28-1
Flam. Liq. 3; Acute Tox. 3; Acute Tox. 4; STOT RE 2; Eye Dam. 1; Skin Sens. 1
428-340-9
238088-70-5
Skin Irrit. 2
204-435-9
120-92-3
Flam. Liq. 3; Eye Irrit. 2; Skin Irrit. 2
227-964-7
6053-68-5
Eye Irrit. 2; STOT SE 3
206-016-6
287-92-3
Flam. Liq. 2
VIOLIFF
401-620-8
87731-18-8
Skin Sens. 1
220-279-4
2699-11-8
Org. Perox. A; Skin Corr. 1B; Acute Tox. 4
220-279-4
2699-11-8
Org. Perox. C; Acute Tox. 4; Skin Corr. 1B
CHMMS; CHMS; DYNASYLAN 9407; Z-6187
402-140-1
17865-32-6
Skin Irrit. 2
203-629-0
108-91-8
Flam. Liq. 3; Repr. 2; Acute Tox. 4; Skin Corr. 1B
221-319-3
3066-71-5
STOT SE 3; Skin Irrit. 2
200-636-0
66-81-9
Muta. 2; Repr. 1B; Acute Tox. 2
235-527-7
12262-58-7
Org. Perox. A; Skin Corr. 1B; Acute Tox. 4
235-527-7
12262-58-7
Org. Perox. C; Acute Tox. 4; Skin Corr. 1B
203-631-1
108-94-1
Flam. Liq. 3; Acute Tox. 4
203-630-6
108-93-0
Acute Tox. 4; STOT SE 3; Skin Irrit. 2
201-604-9
85-42-7
Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
203-806-2
110-82-7
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
431-730-1
4277-06-9
Skin Irrit. 2; Skin Sens. 1
427-230-8
5571-36-8
Repr. 1B; STOT RE 2
CSDCA
419-150-7
113136-77-9
Acute Tox. 4
223-099-4
3734-95-0
Acute Tox. 2; Acute Tox. 3
220-130-3
2636-26-2
Acute Tox. 4
620-377-0
13067-93-1
Acute Tox. 3; STOT SE 1; Acute Tox. 4; Eye Irrit. 2
244-544-9
21725-46-2
Acute Tox. 4
206-992-3
420-04-2
Carc. 2; Repr. 2; Acute Tox. 3; STOT RE 2; Skin Corr. 1; Skin Sens. 1; Eye Dam. 1
202-704-5
98-82-8
Flam. Liq. 3; Carc. 1B; Asp. Tox. 1; STOT SE 3
-
-
P Parasites
-
-
P Parasites
-
-
F Fungi
-
-
F Fungi
206-083-1
299-86-5
Acute Tox. 4
231-720-5
7700-17-6
Acute Tox. 3
224-030-0
4170-30-3
Flam. Liq. 2; Muta. 2; Acute Tox. 2; Acute Tox. 3; STOT RE 2; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
208-622-6
535-89-7
Acute Tox. 2
-
-
V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
-
-
V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
The low-boiling distillation fraction obtained from the high temperature carbonization of bituminous coal, which is further refined to remove excess crystalline salts. It consists primarily of creosote oil with some of the normal polynuclear aromatic salts, which are components of coal tar distillate, removed. It is crystal free at approximately 38°C (100°F).
274-566-4
70321-80-1
Carc. 1B
The high-boiling distillation fraction obtained from the high temperature carbonization of bituminous coal which is further refined to remove excess crystalline salts. It consists primarily of creosote oil with some of the normal polynuclear aromatic salts, which are components of coal tar distillates, removed. It is crystal free at approximately 5°C (41°F).
274-565-9
70321-79-8
Carc. 1B
A complex combination of hydrocarbons produced by the distillation of coal tar and boiling in the range of approximately 240°C to 280°C (464°F to 536°F). Composed primarily of acenaphthene, naphthalene and alkyl naphthalene.
292-605-3
90640-84-9
Carc. 1B
The oil remaining after removal by a crystallization process of acenaphthene from acenaphthene oil from coal tar. Composed primarily of naphthalene and alkylnaphthalenes.
292-606-9
90640-85-0
Carc. 1B
A complex combination of hydrocarbons obtained by the distillation of coal tar. It consists primarily of aromatic hydrocarbons and may contain appreciable quantities of tar acids and tar bases. It distills at the approximate range of 200°C to 325°C (392°F to 617°F).
263-047-8
61789-28-4
Carc. 1B
The distillate of coal tar produced by the high temperature carbonization of bituminous coal. It consists primarily of aromatic hydrocarbons, tar acids and tar bases.
232-287-5
8001-58-9
Carc. 1B
-
-
V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
-
-
B Bacteria and similar species
-
-
V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.

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