EU-PRODUCT_SAFETY-ART_2

General Product Safety Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of General Product Safety Directive (2001/95/EC), 15 January 2002, amended by Reg 596/2009/EC, 18 July 2009

This list contains a non-exhaustive inventory of substances that fall within the European Union's hazardous substance definitions, as provided on: (1) Table 3 of Annex VI to the CLP Regulation 1272/2008/EC; (2) Annex III of Directive 2000/54/EC (Biological Agents); Candidate List of SVHCs; and REACH Annexes XIV and XVII (Authorisation and Restriction lists). They can be considered hazardous for purposes of the General Product Safety Directive 2001/95/EC.

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Last updated 03 May 2024. Database contains 5503 unique substances/entries.
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Substance Name
EC No.
CAS No.
EU CLP (1272/2008)
EU REACH: Annex XIV
EU REACH: List of SVHC
EU REACH: Annex XVII
EU_BA Directive 2000/54/EC
5-methoxy-4'-(trifluoromethyl)valerophenone
VALEROPHENONE
425-000-1
61718-80-7
yes
5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile
421-300-1
138564-59-7
yes
5-methylheptan-3-one
208-793-7
541-85-5
yes
5-methylhexan-2-one; isoamyl methyl ketone
203-737-8
110-12-3
yes
5-methylpyrazine-2-carboxylic acid
5-METHYLPYRAZINE-2-CARBOXYLIC ACID; ACIDO 5-METILPIRAZIN CARBOSSILICO
413-260-9
5521-55-1
yes
5-nitro-o-toluidine
202-765-8
99-55-8
yes
5-nitro-o-toluidine hydrochloride
256-960-8
51085-52-0
yes
5-nitroacenaphthene
210-025-0
602-87-9
yes
Annex 17 Appendix 2
5-sec-Butyl-2-(2,4-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [1], 5-sec-butyl-2-(4,6-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [2] [covering any of the individual stereoisomers of [1] and [2] or any combination thereof]
-
-
yes
5-sec-Butyl-2-(2,4-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane;5-sec-Butyl-2-(2,4-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [1], 5-sec-butyl-2-(4,6-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [2] [covering any of the individual stereoisomers of [1] and [2] or any combination thereof]
-
-
yes
5-sec-Butyl-2-(2,4-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane;5-sec-Butyl-2-(2,4-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [1], 5-sec-butyl-2-(4,6-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [2] [covering any of the individual stereoisomers of [1] and [2] or any combination thereof]
-
-
yes
5-sec-butyl-2-(4,6-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane
-
-
yes
5-tert-butyl-3-isoxazolylamine hydrochloride
BISOX HCL
404-840-2
164578-13-6
yes
5-thiazolylmethanol
A-87440.0; A-87440.00
414-780-9
38585-74-9
yes
5-{4-[5-amino-2-[4-(2-sulfoxyethylsulfonyl)phenylazo]-4-sulfo-phenylamino]-6-chloro-1,3,5-triazin-2-ylamino}-4-hydroxy-3-(1-sulfo-naphthalen-2-ylazo)-naphthalene-2,7-disulfonicacid sodium salt
ROUGE TZ 4075
418-340-7
157707-94-3
yes
6'-(dibutylamino)-3'-methyl-2'-(phenylamino)spiro[isobenzofuran-1(3H),9-(9H)-xanthen]-3-one
B 290; BK 400; CK 34; DIBUTYL-N-102; DX-20; FAT NR. 40391/A; FLUORAN BLACK BD 869; FLUORAN SCHWARZ BD 869; NOIR FLUORANE BD 869; ODB-2; PSD-290; SENOR-2; TG-31; TH-108; WINCON-2
403-830-5
89331-94-2
yes
6'-(isobutylethylamino)-3'-methyl-2'-phenylamino-spiro[isobenzo-2-oxofuran-7,9'-[9H]-xanthene]
PSD-184
410-890-6
95235-29-3
yes
6,13-dichloro-3,10-bis{2-[4-fluoro-6-(2-sulfophenylamino)-1,3,5-triazin-2-ylamino]propylamino}benzo[5,6][1,4]oxazino[2,3-.b.]phenoxazine-4,11-disulphonic acid, lithium-, sodium salt
BLEU REN 20
418-000-8
163062-28-0
yes
6,6'-bis(diazo-5,5', 6,6'-tetrahydro-5,5'-dioxo)[methylene-bis(5-(6-diazo-5,6-dihydro-5-oxo-1-naphthylsulphonyloxy)-6-methyl-2-phenylene]di(naphthalene-1-sulfonate)
441-550-5
-
yes
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol; [DBMC]
204-327-1
119-47-1
yes
yes
Annex 17 Appendix 6
6,7-dihydrodipyrido[1,2-α:2',1'- c]pyrazinediylium dihydroxide
301-467-6
94021-76-8
yes
6,9-bis(hexadecyloxymethyl)-4,7-dioxanonane-1,2,9-triol
CHIMEXANE NT
411-450-6
143747-72-2
yes
6-(1α,5aβ,8aβ,9-pentahydroxy-7β-isopropyl-2β,5β,8β-trimethylperhydro-8bα,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl) pyrrole-2-carboxylate; ryania
239-732-2
15662-33-6
yes
6-(2,3-dimethylmaleimido)hexyl methacrylate
RONACAT RO 305; RONACOAT RO 305
404-870-6
63740-41-0
yes
6-(2-chloro-6-cyano-4-nitrophenylazo)-4-methoxy-3-[N-(methoxycarbonylmethyl)-N-(1-methoxycarbonylethyl)amino]acetanilide
430-500-8
204277-61-2
yes
6-(nonylamino)-6-oxo-peroxyhexanoic acid
ELFADOX EN 3001
406-680-9
104788-63-8
yes
6-(phthalimido)peroxyhexanoic acid
PAP
410-850-8
128275-31-0
yes
6-[(C10-C13)-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid
701-118-1
2156592-54-8
yes
Annex 17 Appendix 6
6-[C12-18-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid
701-162-1
-
yes
Annex 17 Appendix 6
6-[C12-18-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid, sodium and tris(2-hydroxyethyl)ammonium salts
701-271-4
-
yes
Annex 17 Appendix 6
6-anilino-1-benzoyl-4-(4-tert-pentylphenoxy)naphto[1,2,3-de]quinoline-2,7-(3H)-dione
ESTOFIL ROUGE S-FBL
412-480-2
72453-58-8
yes
6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one
CP-89,575
421-320-0
118289-55-7
yes
6-dimethylaminohexan-1-ol
AF-507; M-3181
404-680-3
1862-07-3
yes
6-docosyloxy-1-hydroxy-4-(1-(4-hydroxy-3-methylphenanthren-1-yl)-3-oxo-2-oxaphenalen-1-yl)naphthalene-2-carboxylic acid
ENS 131
404-550-6
130263-41-1
yes
6-ethyl-5-fluoro-4(3H)-pyrimidone
UK-103,442
422-460-5
137234-87-8
yes
6-fluoro-2-methyl-3-(4-methylthiobenzyl)indene
IN-4; INDENE IN-4
405-410-7
41201-60-9
yes
6-glycidyloxynapht-1-yl oxymethyloxirane
429-960-2
27610-48-6
yes
6-hydroxy-1-(3-isopropoxypropyl)-4-methyl-2-oxo-5-[4-(phenylazo)phenylazo]-1,2-dihydro-3-pyridinecarbonitrile
ARANCIO DISPERSO 149; C.I. DISPERSE ORANGE 149; DISPERS ORANGE 149; DISPERSE ORANGE 149; ORANGE DISPERSE 149; TERASIL GOLDGELB 2RS
400-340-3
85136-74-9
yes
Annex 17 Appendix 2
6-hydroxyindole
IMEXINE OBA
417-020-4
2380-86-1
yes
6-methoxy-m-toluidine; p-cresidine
204-419-1
120-71-8
yes
yes
Annex 17 Appendix 2
6-methyl-2,4-bis(methylthio)phenylene-1,3-diamine
DM-C-TDA; DMTDA; ETHACURE (R) 300 CURATIVE
403-240-8
106264-79-3
yes
6-phenyl-1,3,5-triazine-2,4- diyldiamine; 6-phenyl-1,3,5-triazine-2,4-diamine; benzoguanamine
202-095-6
91-76-9
yes
6-tert-butyl-3-(3-dodecylsulfonyl)propyl-7H-1,2,4-triazolo[3.4b][1,3,4]thiadiazine
424-950-4
133949-92-5
yes
6-tert-butyl-7-(6-diethylamino-2-methyl-3-pyridylimino)-3-(3-methylphenyl)pyrazolo[3,2-c][1,2,4]triazole
KC-27
416-490-8
162208-01-7
yes
6-tert-butyl-7-chloro-3-tridecyl-7,7a-dihydro-1H-pyrazolo[5,1-c]-1,2,4-triazole
AGK 3404
419-870-1
159038-16-1
yes
7,7,9(or 7,9,9)-trimethyl-4,13-dioxo-3,14-dioxa-5,12-diazahexadecane-1,16-diyl bismethacrylate
276-957-5
72869-86-4
yes
7,7-dimethyl-3-oxa-6-azaoctan-1-ol
FLEXSORB-SE
400-390-6
87787-67-5
yes
7-[((4,6-dichloro-1,3,5-triazin-2-yl)amino)-4-hydroxy-3-(4-((2-sulfoxy)ethyl)sulfonyl)phenylazo]naphthalene-2-sulfonic acid
ORANGE BIREACTIVE DYE
407-050-6
117715-57-8
yes
7-amino-3-((5-carboxymethyl-4- methyl-1,3-thiazol-2- ylthio)methyl)-8-oxo-5-thia-1- azabicyclo(4.2.0)oct-2-ene-2- carboxylic acid
TACS
403-690-5
111298-82-9
yes
7-amino-4-hydroxy-2-naphthalenesulfonic acid, coupled with 5 (or 8) -amino-8 (or 5)-[[4-[[4-[[4-amino-6(or 7)-sulfo-1-naphthyl]azo]phenyl]amino]-3-sulfophenyl]azo]-2-naphthalenesulfonic acid and 4-hydroxy-7-(phenylamino)-2-naphthalenesulfonic acid, sodium salt
424-850-0
189702-72-5
yes
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
FLUORCHINOLONCARBONSÄURE
405-050-0
86393-33-1
yes
7-Methoxy-6-(3-morpholin-4-yl-propoxy)-3H-quinazolin-4-one; [containing > 0,5 % formamide (EC No 200-842-0)];7-methoxy-6-(3-morpholin-4-yl-propoxy)-3H-quinazolin-4-one [containing < 0,5 % formamide (EC No 200-842-0)];7-methoxy-6-(3-morpholin-4-yl-propoxy)-3H-quinazolin-4-one [containing ≥ 0,5 % formamide (EC No 200-842-0)]
429-400-7
199327-61-2
yes
7-Methoxy-6-(3-morpholin-4-yl-propoxy)-3H-quinazolin-4-one; [containing > 0,5 % formamide (EC No 200-842-0)];7-methoxy-6-(3-morpholin-4-yl-propoxy)-3H-quinazolin-4-one [containing < 0,5 % formamide (EC No 200-842-0)];7-methoxy-6-(3-morpholin-4-yl-propoxy)-3H-quinazolin-4-one [containing ≥ 0,5 % formamide (EC No 200-842-0)]
429-400-7
199327-61-2
yes
Annex 17 Appendix 6
7-Methoxy-6-(3-morpholin-4-yl-propoxy)-3H-quinazolin-4-one; [containing > 0,5 % formamide (EC No 200-842-0)];7-methoxy-6-(3-morpholin-4-yl-propoxy)-3H-quinazolin-4-one [containing < 0,5 % formamide (EC No 200-842-0)];7-methoxy-6-(3-morpholin-4-yl-propoxy)-3H-quinazolin-4-one [containing ≥ 0,5 % formamide (EC No 200-842-0)]
429-400-7
199327-61-2
Annex 17 Appendix 6
7-methylocta-1,6-diene
7-METHYL-1,6-OCTADIENE
404-210-7
42152-47-6
yes
7-oxa-3-oxiranylbicyclo [4.1.0]heptane; 1,2-epoxy- 4-epoxyethylcyclohexane; 4-vinylcyclohexene diepoxide
203-437-7
106-87-6
yes
Annex 17 Appendix 2; Annex 17 Appendix 6
7a-ethyl-3,5-bis(1-methylethyl)-2,3,4,5-tetrahydrooxazolo[3,4-c]-2,3,4,5-tetrahydrooxazole
ZOLDINE RD-20
417-140-7
79185-77-6
yes
8,8-dimethyl-7-isopropyl-6,10-dioxaspiro[4.5]decane
OPALAL
424-030-2
62406-73-9
yes
8,9,10-trinorborn-2-yl acrylate
-
10027-06-2
yes
8,9,10-trinorborn-5-ene-2,3-dicarboxylic anhydride
204-957-7
129-64-6
yes
8,9-dinorborn-5-ene-2,3-dicarboxylic anhydride
620-411-4
123748-85-6
yes
8-amino-7-methylquinoline
8-AMINO-7-METHYLCHINOLIN
412-760-4
5470-82-6
yes
8-azaspiro[4.5]decane-7,9-dione
3,3-TETRAMETHYLENE GLUTARIMIDE
427-770-4
1075-89-4
yes
8-p-menthyl hydroperoxide; p-menthane hydroperoxide
201-281-4
80-47-7
yes
9,9-bis(4-hydroxyphenyl)fluorene
BPFL; FLUOREN-BIS-PHENOL
406-950-6
3236-71-3
yes
9-(2-propenyloxy)tricyclo[5.2.1.0(2,6)]dec-3(or-4-)-ene
FLEUROXENE
430-830-2
26912-64-1
yes
9-[2-(ethoxycarbonyl) phenyl]-3,6-bis(ethylamino)–2,7-dimethylxanthylium chloride; Basic Red 1
213-584-9
989-38-8
yes
9-vinylcarbazole
216-055-0
1484-13-5
yes
[(1-methyl-1,2-ethanediyl)bis[nitrilobis(methylene)]]tetrakis(phosphonic acid)
421-940-1
28698-31-9
yes
[(4S, 5S)-4-benzyl-2-oxo-5-oxazolidinyl]methyl 4-nitrobenzenesulfonate
416-360-0
162221-28-5
yes
[(dimethylsilylene)bis((1,2,3,3a,7a-η)-1H-inden-1-ylidene)dimethyl]hafnium
M1
422-060-0
137390-08-0
yes
[(m-tolyloxy)methyl]oxirane
218-575-3
2186-25-6
yes
[(p-tolyloxy)methyl]oxirane
218-574-8
2186-24-5
yes
[(tolyloxy)methyl]oxirane; cresyl glycidyl ether
247-711-4
26447-14-3
yes
[1R-(1-α, 2β,5α)]-mono[5-methyl-2-(1-methylethyl)cyclohexyl]butanedioate
426-890-4
77341-67-4
yes
[2-[(4-nitrophenyl)amino]ethyl]urea
NITROGELB
410-700-1
27080-42-8
yes
[3-(chlorocarbonyl)-2-methylphenyl]acetate
433-690-0
167678-46-8
yes
[4-[[4-anilino-1-naphthyl][4-(dimethylamino)phenyl]methylene]cyclohexa-2,5-dien-1-ylidene] dimethylammonium chloride; C.I. Basic Blue 26
219-943-6
2580-56-5
yes
[[2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl] acetic acid
419-270-1
123599-82-6
yes
[carbonato(2-)] tetrahydroxytrinickel
235-715-9
12607-70-4
yes
Annex 17 Appendix 1; Annex 17 Appendix 6
[N-(1,1-dimethylethyl)-1,1-dimethyl-1-[(1,2,3,4,5-η)-2,3,4,5-tetramethyl-2,4-cyclopentadien-1-yl]silanaminato(2-)-κN][(1,2,3,4-η)-1,3-pentadiene]-titanium
419-840-8
169104-71-6
yes
[phosphinyldynetris(oxy)] tris[3-aminopropyl-2-hydroxy-N, N-dimethyl-N-(C6-18)-alkyl] trichlorides
425-520-9
197179-61-6
yes
[Phthalato(2-)]dioxotrilead
273-688-5
69011-06-9
yes
[R-(R*,S*)]-[[2-methyl-1-(1-oxopropoxy)propoxy]-(4-phenylbutyl)phosphinyl] acetic acid, (-)-cinchonidine (1:1) salt
SQ 28,796
415-820-8
137590-32-0
yes
[S-(Z,E)]-5-(1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl)-3-methylpenta-2,4-dienoic acid; S-abscisic acid
244-319-5
21293-29-8
yes
[μ-[carbonato(2-)-O:O']]dihydroxy trinickel
265-748-4
65405-96-1
yes
Annex 17 Appendix 1; Annex 17 Appendix 6
A reaction mass of: (1,3-dioxo-2H-benz(de)isoquinolin-2-ylpropyl)hexadecyldimethylammonium 4-toluenesulfonate; (1,3-dioxo-2H-benz(de)isoquinolin-2-ylpropyl)hexadecyldimethylammonium bromide
CCA-VERSUCHSPRODUKT SN 4001
405-080-4
118725-24-9
yes
abamectin (combination of avermectin B1a and avermectin B1b) (ISO)
615-339-5
71751-41-2
yes
Absettarov
-
-
V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Absorption oils, bicyclo arom. and heterocyclic hydrocarbon fraction; Wash Oil Redistillate [A complex combination of hydrocarbons obtained as a redistillate from the distillation of wash oil. It consists predominantly of 2-ringed aromatic and heterocyclic hydrocarbons boiling in the range of approximately 260 °C to 290 °C (500°F to 554°F).]
A complex combination of hydrocarbons obtained as a redistillate from the distillation of wash oil. It consists predominantly of 2-ringed aromatic and heterocyclic hydrocarbons boiling in the range of approximately 260°C to 290°C (500°F to 554°F).
309-851-5
101316-45-4
yes
Annex 17 Appendix 2
Acanthamoeba castellani
-
-
P Parasites
acephate (ISO); O, S-dimethyl acetylphosphoramidothioate
250-241-2
30560-19-1
yes
acequinocyl (ISO); 3-dodecyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl acetate
611-595-7
57960-19-7
yes
acetaldehyde; ethanal
200-836-8
75-07-0
yes
Annex 17 Appendix 2
acetamide
200-473-5
60-35-5
yes
acetamiprid (ISO); (1E)-N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methylethanimidamide; (E)-N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine
603-921-1
135410-20-7
yes
acetamiprid (ISO); (1E)-N-[(6-chloropyridin-3-yl)methyl]-N’-cyano-N-methylethanimidamide; (E)-N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine
682-791-8
160430-64-8
yes
acetic acid ... %
200-580-7
64-19-7
yes
Acetic acid, lead salt, basic
257-175-3
51404-69-4
yes
acetic anhydride
203-564-8
108-24-7
yes
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