EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

This list contains hazardous substances for purposes of Directive 90/385/EEC on active implantable medical devices, particularly as regards Article 3 and Annex I (Essential Requirements). This non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Please note that Regulation (EU) 2017/745 on medical devices has repealed Directive 90/385/EEC and begun to apply from 26 May 2021. Nevertheless, Article 120 of the Regulation provides for a transitional period allowing medical devices, under specified conditions (e.g., placed on the market prior to 26 May 2021), to continue to comply with the Directive. In accordance with the fourth paragraph of Article 120, this period ends 26 May 2025.

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Last updated 03 May 2024. Database contains 4753 unique substances/entries.
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Substance Name
EC No.
CAS No.
EU CLP (1272/2008)
EU_BA Directive 2000/54/EC
EU REACH: List of SVHC
methyl 2-(2-nitrobenzylidene)acetoacetate
2-NITROBENZYLIDENE METHYL ESTER; BAY O 2787
400-650-9
39562-27-1
Skin Sens. 1
methyl 2,5-dichlorobenzoate
220-815-7
2905-69-3
Acute Tox. 4; STOT SE 3
methyl 2,2-dimethyl-6-methylenecyclohexanecarboxylate
432-350-9
81752-87-6
Skin Irrit. 2
methyl (±)-lactate;methyl lactate
208-930-0
2155-30-8;547-64-8
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3
methyl (±)-lactate;methyl lactate
208-930-0
2155-30-8;547-64-8
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3
methyl (S)-(-)-lactate
248-704-9
27871-49-4
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3
methyl (R)-lactate
241-420-6
17392-83-5
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3
methyl (R)-2-(4-hydroxyphenoxy)propionate
DHPPME; MAK-ME; MEHPOPS; R-MAQ-ME
411-950-4
96562-58-2
Eye Dam. 1
methyl (R)-2-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxy)propionate
HALOXYFOP R-(+)-ME HERBICIDAL CHEMICAL
406-250-0
72619-32-0
Acute Tox. 4
methyl (9-acetoxy-3,8,10-triethyl-7,8,10-trimethyl-1,5-dioxa-9-aza-spiro[5.5]undec-3-yl)octadecanoate
445-990-9
376588-17-9
Skin Sens. 1
methyl (3aR,4R,7aR)-2-methyl-4-(1S,2R,3-triacetoxypropyl)-3a,7a-dihydro-4H-pyrano[3,4-d]oxazole-6-carboxylate
GR138766X
415-670-3
78850-37-0
Eye Dam. 1
methoxyacetic acid
210-894-6
625-45-6
Repr. 1B; Acute Tox. 4; Skin Corr. 1B
yes
methomyl (ISO); 1-(methylthio)ethylideneamino N-methylcarbamate
240-815-0
16752-77-5
Acute Tox. 2
methidathion (ISO); 2,3-dihydro-5-methoxy-2-oxo-1,3,4-thiadiazol-3-ylmethyl-O,O-dimethylphosphorodithioate
213-449-4
950-37-8
Acute Tox. 2; Acute Tox. 4
methenamine; hexamethylenetetramine
202-905-8
100-97-0
Flam. Sol. 2; Skin Sens. 1
methanol
200-659-6
67-56-1
Flam. Liq. 2; Acute Tox. 3; STOT SE 1
methanethiol; methyl mercaptan
200-822-1
74-93-1
Flam. Gas 1; Press. Gas; Acute Tox. 3
methanesulphonic acid
200-898-6
75-75-2
Skin Corr. 1B
methane
200-812-7
74-82-8
Flam. Gas 1; Press. Gas
methamidophos (ISO); O,S-dimethyl phosphoramidothioate
233-606-0
10265-92-6
Acute Tox. 2; Acute Tox. 3
methacrylonitrile; 2-methyl-2-propene nitrile
204-817-5
126-98-7
Flam. Liq. 2; Acute Tox. 3; Skin Sens. 1
methacrylic acid; 2-methylpropenoic acid
201-204-4
79-41-4
Acute Tox. 4; Skin Corr. 1A
methacrifos (ISO); methyl (E)-3-[(dimethoxyphosphinothioyl)oxy]methacrylate
630-448-8
62610-77-9
Acute Tox. 4; Skin Sens. 1
metconazole (ISO); (1RS, 5RS;1RS, 5SR)-5-(4-chlorobenzyl)-2,2-dimethyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol
603-031-3
125116-23-6
Repr. 2; Acute Tox. 4
metazachlor (ISO); 2-chloro-N-(2,6-dimethylphenyl)-N-(1H-pyrazol-1-ylmethyl)-acetamide
266-583-0
67129-08-2
Skin Sens. 1B; Carc. 2
metamitron (ISO);4-amino-3-methyl-6-phenyl-1,2,4-triazin-5-one
255-349-3
41394-05-2
Acute Tox. 4
metam-sodium (ISO); sodium methyldithiocarbamate
205-293-0
137-42-8
Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
metalaxyl-M (ISO); mefenoxam; (R)-2-[(2,6-dimethylphenyl)-methoxyacetylamino]propionic acid methyl ester
615-135-6
70630-17-0
Acute Tox. 4; Eye Dam. 1
metalaxyl (ISO); methyl-N-(2,6-dimethylphenyl)-N-(methoxyacetyl)-DL-alaninate
260-979-7
57837-19-1
Acute Tox. 4; Skin Sens. 1
metal salts of thiocyanic acid, with the exception of those specified elsewhere in this Annex
-
-
Acute Tox. 4
metaflumizone (ISO); (EZ)-2-[2-(4-cyanophe-nyl)-1-(a,a,a -trifluoro-m-tolyl)ethylidene]-[4-(tri-fluoromethoxy)phenyl] carbanilohydrazide [E-iso-mer > 90 %, Z-isomer <10 % relative content]; [1] (E)-2-[2-(4-cyanophenyl)-1-(a,a,a -trifluoro-m-tolyl) ethylidene]-[4-(trifluoro-methoxy)phenyl]carbani-lohydrazide [2]
604-167-6
139968-49-3
Repr. 2; Lact.; STOT RE 2
metaflumizone (ISO); (EZ)-2-[2-(4-cyanophe-nyl)-1-(a,a,a -trifluoro-m-tolyl)ethylidene]-[4-(tri-fluoromethoxy)phenyl] carbanilohydrazide [E-iso-mer > 90 %, Z-isomer <10 % relative content]; [1] (E)-2-[2-(4-cyanophenyl)-1-(a,a,a -trifluoro-m-tolyl) ethylidene]-[4-(trifluoro-methoxy)phenyl]carbani-lohydrazide [2]
701-454-9
852403-68-0
Repr. 2; Lact.; STOT RE 2
mesotrione(ISO); 2-[4-(methylsulfonyl)-2-nitrobenzoyl]-1,3-cyclohexanedione
600-533-4
104206-82-8
Repr. 2; STOT RE 2
mesitylene; 1,3,5-trimethylbenzene
203-604-4
108-67-8
Flam. Liq. 3; STOT SE 3
mercury difulminate; mercuric fulminate; fulminate of mercury;mercury difulminate; mercuric fulminate; fulminate of mercury [≥ 20 % phlegmatiser]
211-057-8
628-86-4
Unst. Expl.; Acute Tox. 3; STOT RE 2
mercury difulminate; mercuric fulminate; fulminate of mercury;mercury difulminate; mercuric fulminate; fulminate of mercury [≥ 20 % phlegmatiser]
211-057-8
628-86-4
Expl. 1.1; Acute Tox. 3; STOT RE 2
mercury dichloride; mercuric chloride
231-299-8
7487-94-7
Muta. 2; Repr. 2; Acute Tox. 2; STOT RE 1; Skin Corr. 1B
mercury
231-106-7
7439-97-6
Repr. 1B; Acute Tox. 2; STOT RE 1
mercaptodimethur (ISO); methiocarb (ISO); 3,5-dimethyl-4-methylthiophenyl N-methylcarbamate
217-991-2
2032-65-7
Acute Tox. 3
mequinol; 4-methoxyphenol; hydroquinone monomethyl ether
205-769-8
150-76-5
Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
mephosfolan (ISO); diethyl 4-methyl-1,3-dithiolan-2-ylidenephosphoramidate
213-447-3
950-10-7
Acute Tox. 1; Acute Tox. 2
mepanipyrim; 4-methyl-N-phenyl-6-(1-propynyl)-2-pyrimidinamine
432-140-7
110235-47-7
Carc. 2
menazon (ISO); S-[(4,6-diamino-1,3,5-triazin-2-yl)methyl] O, O-dimethyl phosphorodithioate
201-123-4
78-57-9
Acute Tox. 4
menadione sodium bisulfite; 2-naphthalenesulfonic acid,1,2,3,4-tetrahydro-2-methyl-1,4-dioxo-, sodium salt
204-987-0
130-37-0
Eye Irrit. 2; Skin Irrit. 2
menadione nicotinamide bisulfite; 1,2,3,4-tetrahydro-2-methyl-1,4-dioxonaphthalene-2-sulfonicacid, compound with nicotin-3-amide (1:1)
277-543-7
73581-79-0
Eye Irrit. 2; Skin Irrit. 2
medinoterb acetate (ISO); 6-tert-butyl-3-methyl-2,4-dinitrophenyl acetate
219-634-6
2487-01-6
Acute Tox. 3; Acute Tox. 4
mecrilate; methyl 2-cyanoacrylate
205-275-2
137-05-3
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
mecoprop-P [1] and its salts; (R)-2-(4-chloro-2-methylphenoxy)propionic acid
240-539-0
16484-77-8
Acute Tox. 4; Eye Dam. 1
mecoprop-P [1] and its salts; (R)-2-(4-chloro-2-methylphenoxy)propionic acid
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mecoprop-P (ISO); (R)-2-(4-chloro-2-methylphenoxy)propionic acid EC / List no: 240-539-0 | CAS no: 16484-77-8
-
-
Acute Tox. 4; Eye Dam. 1
mecetronium etilsulfate; N-ethyl-N,N-dimethylhexadecan-1-aminium ethyl sulfate; mecetronium ethyl sulphate; [MES]
221-106-5
3006-10-8
Skin Corr. 1; Eye Dam. 1
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