EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

This list contains hazardous substances for purposes of Directive 90/385/EEC on active implantable medical devices, particularly as regards Article 3 and Annex I (Essential Requirements). This non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Please note that Regulation (EU) 2017/745 on medical devices has repealed Directive 90/385/EEC and begun to apply from 26 May 2021. Nevertheless, Article 120 of the Regulation provides for a transitional period allowing medical devices, under specified conditions (e.g., placed on the market prior to 26 May 2021), to continue to comply with the Directive. In accordance with the fourth paragraph of Article 120, this period ends 26 May 2025.

Last updated 30 April 2024. Database contains 4753 unique substances/entries.
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939-993-9
-
yes
939-460-0
1471311-26-8
yes
938-618-6
-
yes
936-037-2
-
yes
show/hide
Proteinase, Myxobacter AL-1, II EC / List no: 276-716-4 | CAS no: 72561-05-8
Proteinase, microbial acid EC / List no: 256-862-5 | CAS no: 50936-52-2
Proteinase, Aspergillus alkaline EC / List no: 232-977-6 | CAS no: 9074-07-1
Proteinase, Bothrops atrox serine EC / List no: 232-918-4 | CAS no: 9039-61-6
Proteinase, oryzin EC / List no: 232-992-8 | CAS no: 9081-30-5
Proteinase, Bacillus polymyxa neutral EC / List no: 255-914-4 | CAS no: 42613-33-2
Proteinase, microbial alkaline EC / List no: 256-863-0 | CAS no: 50936-53-3
Proteinase, Bacillus alcalophilus serine EC / List no: 306-090-0 | CAS no: 95979-76-3
Amylase, mixed with proteinase, Bacillus cereus-fermented EC / List no: - | CAS no: 68909-35-3
Bacteria, complex with amylase and proteinase EC / List no: - | CAS no: 68920-42-3
Proteinase, Mucor aspartic EC / List no: 232-975-5 | CAS no: 9073-79-4
Proteinase, Aspergillus acid EC / List no: 232-796-2 | CAS no: 9025-49-4
Proteinase, aspartic EC / List no: 278-856-1 | CAS no: 78169-47-8
Proteinase, Bacillus subtilis metallo- EC / List no: 232-991-2 | CAS no: 9080-56-2
Proteinase, submandibular gland serine, A EC / List no: 279-893-6 | CAS no: 82047-85-6
Proteinase, Bacillus neutral EC / List no: 278-547-1 | CAS no: 76774-43-1
Proteinase, serine EC / List no: 253-431-3 | CAS no: 37259-58-8
Thrombin EC / List no: 232-648-7 | CAS no: 9002-04-4
Proteinase, Bacillus alkaline EC / List no: 232-972-9 | CAS no: 9073-77-2
Proteinase, serine (Tritirachium album) EC / List no: 686-165-5 | CAS no: 102925-54-2
Proteinase, Tritirachium album serine EC / List no: 254-457-8 | CAS no: 39450-01-6
Proteinase, Aspergillus oryzae neutral EC / List no: 232-990-7 | CAS no: 9080-55-1
Bacillus megaterium protease fermentation product EC / List no: - | CAS no: 68909-17-1
Proteinase, Bacillus subtilis serine EC / List no: 266-557-9 | CAS no: 67051-83-6
Proteinase, Aspergillus parasiticus neutral EC / List no: 254-418-5 | CAS no: 39335-09-6
Amylase, mixture with proteinase EC / List no: 685-079-5 | CAS no: 9001-11-0
Proteinase, Staphylococcus aureus serine EC / List no: 259-611-8 | CAS no: 55354-32-0
Proteinase, rhizopus acid EC / List no: 812-486-9 | CAS no: 9074-09-3
Proteinase, Endothia aspartic EC / List no: 253-395-9 | CAS no: 37205-60-0
Proteinase, pancreatic EC / List no: 232-626-7 | CAS no: 9001-72-3
Myxobacteralphalyticproteinase EC / List no: - | CAS no: 12585-31-8
Proteinase, Agkistrodon serine EC / List no: 232-933-6 | CAS no: 9046-56-4
Proteinase, Bacillus subtilis, sutilain EC / List no: 235-390-3 | CAS no: 12211-28-8
Proteinase, Aspergillus neutral EC / List no: 278-588-5 | CAS no: 77000-13-6
Proteinase, Bacillus subtilis EC / List no: 257-520-8 | CAS no: 51931-23-8
Proteinase, Bacillus licheniformis serine EC / List no: 279-361-3 | CAS no: 79986-26-8
Proteinase, Myxobacter α-lytic EC / List no: 253-448-6 | CAS no: 37288-76-9
Proteinase, microbial neutral EC / List no: 232-966-6 | CAS no: 9068-59-1
Proteinase, Streptomyces griseus EC / List no: 232-909-5 | CAS no: 9036-06-0
Proteinase, Aspergillus melleus, semialkaline EC / List no: - | CAS no: 76106-83-7
Aspergillin M EC / List no: - | CAS no: 42615-60-1
Proteinase, Serratia extracellular EC / List no: 253-457-5 | CAS no: 37312-62-2
Proteinase, Aspergillus niger neutral EC / List no: 254-422-7 | CAS no: 39346-39-9
Proteinase, bacterial E 30 serine EC / List no: - | CAS no: 39369-34-1
934-013-6
39450-01-6
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
932-998-7
-
yes
931-756-8
-
yes
931-755-2
-
yes
931-754-7
-
yes
931-753-1
-
yes
915-270-3
-
yes
822-682-6
1417782-03-6
Skin Sens. 1
811-718-6
86347-14-0
Acute Tox. 2; STOT SE 3; STOT SE 1; STOT RE 1
807-366-8
946578-00-3
Acute Tox. 4
804-373-8
951659-40-8
Acute Tox. 4; STOT RE 2
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Phenol, p-sec-nonyl-, phosphite EC / List no: - | CAS no: 106599-06-8
Tris(nonylphenyl) phosphite EC / List no: 247-759-6 | CAS no: 26523-78-4
Phenol, p-isononyl-, phosphite (3:1) EC / List no: - | CAS no: 31631-13-7
tris(4-nonylphenyl, branched) phosphite EC / List no: 701-028-2 | CAS no: -
Phenol, 4-nonyl-, phosphite (3:1) EC / List no: 608-492-4 | CAS no: 3050-88-2
799-976-5
-
yes
show/hide
Stannane, dioctyl-, bis(coco acyloxy) derivs. EC / List no: 293-901-5 | CAS no: 91648-39-4
Dioctyltin dilaurate EC / List no: 222-883-3 | CAS no: 3648-18-8
799-973-9
-
yes
701-454-9
852403-68-0
Repr. 2; Lact.; STOT RE 2
701-107-1
1801269-77-1
Repr. 1B; Skin Corr. 1C; Eye Dam. 1
701-105-0
1801269-80-6
Repr. 1B; Skin Corr. 1C; Eye Dam. 1
700-242-3
62037-80-3
yes
695-989-4
2527-66-4
Acute Tox. 4; Acute Tox. 3; Skin Corr. 1C; Eye Dam. 1; Skin Sens. 1A
691-719-4
1072957-71-1
Acute Tox. 3
687-833-9
1119449-38-5
yes
687-832-3
1119449-37-4
yes
686-814-2
34363-01-4
Skin Irrit. 2; Skin Sens. 1
682-362-5
12527-76-3
Acute Tox. 4
672-776-4
348635-87-0
Carc. 2; Eye Irrit. 2
642-974-5
400882-07-7
Carc. 2; Skin Sens. 1A
641-410-5
130066-44-3
Skin Sens. 1A
640-998-0
7790-78-5
yes
640-104-9
210555-94-5
Repr. 1B; Skin Corr. 1C; Eye Dam. 1
639-478-6
182635-99-0
Acute Tox. 4; Skin Corr. 1B
635-696-0
186825-39-8
yes
635-391-2
142731-63-3
yes
635-389-1
186825-36-5
yes
635-388-6
521947-27-3
yes
635-361-9
243973-20-8
Repr. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Sens. 1A
630-448-8
62610-77-9
Acute Tox. 4; Skin Sens. 1
626-360-4
15244-35-6
yes
621-345-9
2315-67-5
yes
621-341-7
2315-61-9
yes
620-440-2
12510-42-8
Carc. 1A
620-436-0
75736-33-3
Eye Irrit. 2
620-432-9
2122-19-2
Repr. 2; Acute Tox. 4
620-427-1
108173-90-6
Acute Tox. 2; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
620-425-0
68049-83-2
Repr. 1B; STOT RE 2
620-422-4
4097-36-3
Acute Tox. 3
620-419-8
606-35-9
Expl. 1.1; Acute Tox. 4
620-411-4
123748-85-6
Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
620-410-9
4234-79-1
Acute Tox. 3; Acute Tox. 4
620-404-6
7572-29-4
Unst. Expl.; Carc. 2; STOT RE 2
620-403-0
8003-05-2
Acute Tox. 3; STOT RE 1; Skin Corr. 1B
620-400-4
12031-65-1
Carc. 1A; STOT RE 1; Skin Sens. 1
620-395-9
12737-30-3
Carc. 1A; STOT RE 1; Skin Sens. 1
620-379-1
3254-63-5
Acute Tox. 1; Acute Tox. 2
620-378-6
8065-48-3
Acute Tox. 1; Acute Tox. 2
620-377-0
13067-93-1
Acute Tox. 3; STOT SE 1; Acute Tox. 4; Eye Irrit. 2
620-370-2
2703-37-9
Acute Tox. 2; Acute Tox. 1
620-368-1
1031-47-6
Acute Tox. 1; Acute Tox. 2
620-365-5
9016-72-2
Acute Tox. 4; STOT RE 2; Skin Sens. 1
620-362-9
1918-18-9
Acute Tox. 4
620-359-2
8065-36-9
Acute Tox. 3
620-358-7
140-41-0
Carc. 2; Eye Irrit. 2; Skin Irrit. 2
620-041-3
907204-31-3
Lact.
619-823-7
494793-67-8
Carc. 2
619-396-7
99129-21-2
Acute Tox. 4; Skin Sens. 1
619-394-6
99105-77-8
Repr. 2; STOT RE 2; Skin Sens. 1A
619-377-3
98886-44-3
Acute Tox. 3; Acute Tox. 4; Skin Sens. 1
619-020-1
94361-06-5
Repr. 1B; Acute Tox. 3; STOT RE 2
619-000-2
94125-34-5
Acute Tox. 4
618-541-1
9036-19-5
yes
618-392-2
9004-70-0
Expl. 1.1
618-344-0
9002-93-1
yes
618-075-9
87820-88-0
Carc. 2; Acute Tox. 4
618-004-1
87392-12-9
Skin Sens. 1
617-717-5
85509-19-9
Carc. 2; Repr. 1B; Acute Tox. 4
617-485-5
76714-88-0
Acute Tox. 4
617-373-6
82657-04-3
Carc. 2; Acute Tox. 3; Acute Tox. 2; STOT RE 1; Skin Sens. 1B
617-356-3
82560-54-1
Repr. 2; Acute Tox. 3; Acute Tox. 4
617-243-9
81591-81-3
Acute Tox. 4
617-219-8
81334-34-1
Eye Irrit. 2
617-100-0
8051-02-3
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
616-995-5
8018-01-7
Repr. 2; Skin Sens. 1
616-932-1
8011-63-0
Acute Tox. 4; Eye Dam. 1
616-712-5
79622-59-6
Repr. 2; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1A
616-699-6
79538-32-2
Acute Tox. 1; Acute Tox. 2
616-669-2
79241-46-6
Repr. 2
616-584-0
7803-57-8
yes
616-572-5
7790-84-3
yes
616-541-6
7789-12-0
yes
616-510-7
7782-63-0
Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2
616-477-9
7758-99-8
Acute Tox. 4; Eye Dam. 1
616-473-7
77536-68-6
Carc. 1A; STOT RE 1
616-472-1
77536-67-5
Carc. 1A; STOT RE 1
616-471-6
77536-66-4
Carc. 1A; STOT RE 1
616-379-6
76738-62-0
Repr. 2; Acute Tox. 4; Eye Irrit. 2
616-221-6
7541-49-3
Skin Irrit. 2
616-100-8
74499-35-7
Repr. 1B; Skin Corr. 1C; Eye Dam. 1
616-096-8
7446-19-7
Acute Tox. 4; Eye Dam. 1
615-339-5
71751-41-2
Repr. 2; Acute Tox. 2; Acute Tox. 1; STOT RE 1
615-273-7
71283-80-2
STOT RE 2; Skin Sens. 1
615-135-6
70630-17-0
Acute Tox. 4; Eye Dam. 1
614-708-8
68694-11-1
Repr. 1B; Acute Tox. 4; STOT RE 2; Skin Sens. 1
614-346-0
68157-60-8
Carc. 2
614-054-3
67375-30-8
Acute Tox. 3; STOT RE 2; STOT SE 3
613-953-8
66603-10-9
Flam. Sol. 1; Acute Tox. 3; STOT RE 2; Skin Irrit. 2; Eye Dam. 1
613-911-9
66230-04-4
Acute Tox. 3; Skin Sens. 1
613-108-3
62924-70-3
Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
611-802-0
591-34-4
Flam. Liq. 3
611-595-7
57960-19-7
Skin Sens. 1; STOT SE 1; STOT RE 2
611-516-6
57369-32-1
Acute Tox. 4
611-341-5
55965-84-9
Acute Tox. 2; Acute Tox. 3; Skin Corr. 1C; Eye Dam. 1; Skin Sens. 1A
611-089-6
540-67-0
Flam. Gas 1; Press. Gas
610-700-3
51580-86-0
Acute Tox. 4; Eye Irrit. 2; STOT SE 3
610-007-6
422556-08-9
Skin Sens. 1
609-346-2
37205-87-1
yes
608-879-8
335104-84-2
Repr. 2; STOT RE 2; Skin Sens. 1
608-723-9
32289-58-0
Carc. 2; Acute Tox. 2; Acute Tox. 4; STOT RE 1; Eye Dam. 1; Skin Sens. 1B
608-595-4
312600-89-8
Flam. Sol. 1; Acute Tox. 4; STOT RE 2; Eye Dam. 1
608-492-4
3050-88-2
yes
608-042-7
27083-27-8
Carc. 2; Acute Tox. 2; Acute Tox. 4; STOT RE 1; Eye Dam. 1; Skin Sens. 1B
607-955-8
2655-14-3
Acute Tox. 4
607-329-4
24151-93-7
Acute Tox. 4
606-640-2
2079-00-7
Acute Tox. 2
606-566-0
20487-40-5
Flam. Liq. 2
606-523-6
203313-25-1
Repr. 2; STOT SE 3; Eye Irrit. 2; Skin Sens. 1A
606-168-7
189278-12-4
Carc. 2
605-769-1
17606-31-4
Acute Tox. 4
605-752-9
175217-20-6
STOT RE 2
605-747-1
175013-18-0
Acute Tox. 3; Skin Irrit. 2
605-683-4
173584-44-6
Acute Tox. 3; Acute Tox. 4; STOT RE 1; Skin Sens. 1B
605-329-9
163515-14-8
Acute Tox. 4; Skin Sens. 1
605-127-0
158062-67-0
Acute Tox. 4
605-037-1
156052-68-5
Skin Sens. 1
604-715-4
149979-41-9
Carc. 2; Repr. 2
604-712-8
149961-52-4
Carc. 2; Repr. 2; Acute Tox. 4
604-636-5
148477-71-8
Carc. 1B; Repr. 2; STOT RE 2; Skin Sens. 1B
604-430-5
144651-06-9
STOT RE 2
604-398-2
144171-61-9
Acute Tox. 3; Acute Tox. 4; STOT RE 1; Skin Sens. 1B
604-395-6
14409-72-4
yes
604-351-6
143390-89-0
Carc. 2
604-318-6
142891-20-1
Carc. 2; Skin Sens. 1
604-314-4
142844-00-6
yes
604-291-0
142469-14-5
Skin Sens. 1
604-290-5
142459-58-3
Acute Tox. 4; STOT RE 2; Skin Sens. 1
604-237-6
141517-21-7
Skin Sens. 1
604-222-4
141112-29-0
Repr. 2
604-209-3
140923-17-7
Carc. 2
604-167-6
139968-49-3
Repr. 2; Lact.; STOT RE 2
604-105-8
139001-49-3
Carc. 2; Repr. 2; Skin Sens. 1
603-921-1
135410-20-7
Acute Tox. 4
603-902-8
13517-20-9
Repr. 1B; STOT SE 3; Eye Dam. 1
603-902-8
13517-20-9
yes
603-902-8
13517-20-9
Repr. 1B; Acute Tox. 4; STOT SE 3; Eye Dam. 1
603-804-5
134237-52-8
yes
603-802-4
134237-51-7
yes
603-801-9
134237-50-6
yes
603-792-1
134098-61-6
Acute Tox. 3; Acute Tox. 2; Skin Sens. 1B
603-524-3
131860-33-8
Acute Tox. 3
603-520-1
131807-57-3
STOT RE 2
603-411-9
1303-96-4
Repr. 1B
yes
603-404-0
130328-20-0
Repr. 2; Skin Irrit. 2; Eye Dam. 1
603-146-9
126535-15-7
Carc. 2
603-038-1
125225-28-7
Repr. 1B; Acute Tox. 4; STOT RE 2
603-031-3
125116-23-6
Repr. 2; Acute Tox. 4
602-997-3
124495-18-7
Skin Sens. 1
602-929-2
123333-53-9
Expl. 1.3
602-927-1
123312-89-0
Carc. 2; Repr. 2
602-894-3
12280-03-4
Repr. 1B
602-782-4
122453-73-0
Acute Tox. 3; Acute Tox. 4
601-810-2
12185-10-3
Pyr. Sol. 1; Acute Tox. 2; Skin Corr. 1A
601-808-1
12179-04-3
Repr. 1B
yes
601-801-3
12172-73-5
Carc. 1A; STOT RE 1
601-785-8
121552-61-2
Skin Sens. 1
601-650-3
12001-29-5
Carc. 1A; STOT RE 1
601-649-8
12001-28-4
Carc. 1A; STOT RE 1
601-585-0
119168-77-3
Acute Tox. 3; Acute Tox. 4; STOT RE 2; Skin Sens. 1B
601-505-4
118134-30-8
Repr. 2; Acute Tox. 4; STOT RE 2; Skin Irrit. 2; Skin Sens. 1
601-147-9
111988-49-9
Carc. 2; Repr. 1B; Acute Tox. 4; Acute Tox. 3; STOT SE 3
600-765-6
106700-29-2
Acute Tox. 4; Skin Sens. 1
600-662-6
105512-06-9
Acute Tox. 4; STOT RE 2; Skin Sens. 1
600-611-8
10486-00-7
Repr. 1B; Acute Tox. 4; STOT SE 3; Eye Dam. 1
600-611-8
10486-00-7
yes
600-611-8
10486-00-7
Repr. 1B; STOT SE 3; Eye Dam. 1
600-594-7
104653-34-1
Repr. 1B; Acute Tox. 1; STOT RE 1
600-533-4
104206-82-8
Repr. 2; STOT RE 2
600-425-7
103361-09-7
Repr. 1B
600-419-4
10332-33-9
Ox. Sol. 3; Repr. 1B; Acute Tox. 4; STOT SE 3; Eye Dam. 1
600-419-4
10332-33-9
Ox. Sol. 3; Repr. 1B; Acute Tox. 3; Acute Tox. 4; STOT SE 3; Eye Dam. 1
600-419-4
10332-33-9
yes
600-363-0
102851-06-9
Acute Tox. 4; Skin Irrit. 2
600-130-3
100784-20-1
Repr. 1B
1 - 2.5 moles ethoxylated
500-315-8
127087-87-0
yes
1 - 2.5 moles ethoxylated
500-209-1
68412-54-4
yes
1 - 2.5 moles ethoxylated
500-045-0
26027-38-3
yes
500-036-1
25214-70-4
yes
500-033-5
25068-38-6
Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
500-024-6
9016-45-9
yes
451-440-9
586372-44-3
Eye Dam. 1

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