Endocrine disruptor assessment list

Endocrine disruptor assessment list

Endocrine disruptor assessment list

ECHA’s endocrine disruptor (ED) assessment list includes the substances undergoing an ED assessment that have been brought for discussion to ECHA’s ED Expert Group.

Explanatory note

Inclusion in the list means that an informal hazard assessment for endocrine-disrupting properties either is under development or has been completed since February 2013.

For each substance, the table shows the assessing or evaluating Member State (submitter), the outcome from the assessment, and the date of the latest update to the list entry.

Other process details and hazard assessment outcome documents are also available and can be accessed through the ‘Details’ icon.

One possible outcome of such an assessment is that a substance is considered not to have ED properties.

If the outcome is that the substance is considered to have ED properties, confirmation through the formal risk management and decision-making processes under is needed before any regulatory action can be taken due to these properties.

The intentions of authorities to submit a dossier to the formal REACH and CLP processes are notified through the Registry of Intentions. All biocidal active substances have to undergo a formal ED assessment. You can see the status of biocides assessments on the Biocidal Active Substances page.


The information and views set out in the ED assessment list and in the hazard assessment outcome documents are those of the evaluating authority and do not necessarily reflect the position or opinion of the other Member States or ECHA. Neither ECHA nor the evaluating authority nor any person acting on either of their behalves may be held liable for the use, which may be made of the information contained therein. Statements made or information contained in the documents are without prejudice to any formal regulatory activities that ECHA or the Member States may initiate at a later stage. ED assessments and their outcomes are compiled on the basis of information available by the date of the publication of the document.

Nonylphenol, branched, ethoxylated

1 - 2.5 moles ethoxylated EC / List no: 500-209-1 CAS no: 68412-54-4
Endocrine disruption
Date of intention
Date of hazard assessment
Hazard assessment outcome document
This ED assessment case pertains to the SEV case.

Nonylphenol, branched, ethoxylated (EC No 500-315-8, NPEO) has already been identified as SVHC due to its endocrine disrupting properties (Article 57(f) - environment) because it can degrade to 4-nonylphenol, branched which has already been identified as an SVHC due to environmental due to its endocrine disrupting properties.

According to the SEv conclusion, the potential for constituents of the registered substance to cause endocrine disruption themselves in aquatic organisms has not been clarified. More data would be required to clarify the potential for ED-mediated adverse population-relevant effects in fish for NPEO.The eMSCA decided that it would be disproportionate to request such a test from the two Registrants under these circumstances. If new uses or registrations occur in future, the substance may need to be put on the CoRAP again to clarify the endocrine disruption concern of the constituents.
United Kingdom
Submitter organisation
Environment Agency
Submitter email
Submitter phone
Submitter address
UK REACH CA Health and Safety Executive, 4N.G Redgrave Court, Merton Road, Bootle, Merseyside L20 7HS
Latest update
First published