Substances restricted under REACH

Substances restricted under REACH

Substances restricted under REACH

The table below is the Annex XVII to REACH and includes all the restrictions adopted in the framework of REACH and the previous legislation, Directive 76/769/EEC. Each entry shows a substance or a group of substances or a substance in a mixture, and the consequent restriction conditions. The latest consolidated version of REACH presents the restrictions adopted until the date of publication. Subsequent changes are included in the amending Commission regulations.



Further information on the table

The restricted substances (on their own, in a mixture or in an article) are substances for which manufacture, placing on the market or use is limited or banned in the European Union.

The table has been prepared by the European Chemicals Agency (ECHA) to facilitate the searching of restricted substances in the Annex XVII of the REACH Regulation, and the table provides additional information related to the specific restriction entry.

The table contains:

  • Name: the name as given in column 1 of Annex XVII of each entry. In certain cases a group name is not available and the entry number is used instead;
  • EC and CAS numbers; please note that not all the entries in Annex XVII of the REACH Regulation have these numbers. Note also that if it is a group entry, the EC and CAS numbers are under the group member information;
  • Conditions: a document prepared by ECHA that includes the conditions of the restriction according to the latest updated consolidated version of Annex XVII to REACH Regulation. The document also contains the subsequent amendment(s) after the publishing of the consolidated version of REACH;
  • Appendices: links to appendices that concern only certain entries. Please note that searching with CAS or EC numbers is not yet possible for substances restricted under Appendices 1-6 (CMR substances);
  • Standards: links providing information on standards, where available  (links to the CEN search engine for the European standards, or to the international standards' pages);
  • History: links to the original restriction and subsequent amendments;
  • Q&A: the relevant question(s) and answers related to the restriction entry. Please note that the list of Questions and Answers on Restrictions contains also general Q&As, which are not entry specific.

Group members: if there is an entry which concerns several substances (i.e. group entry); the substances within the group entry are described as ‘Group members' and listed in the table. These members are either explicitly mentioned in the specific restriction entry, or they are identified by ECHA in case the entry is of general nature (like cadmium and its compounds). Note that this identification is not yet ready for all entries.

Note that some entries have been deleted from the table:

  • Regulation (EU) No 552/2009: entries 33 and 39 have been deleted (substances severely restricted under Regulation (EC) No 2037/2000 – substances that deplete the ozone layer).
  • Regulation (EU) No 207/2011: entries 44 and 53 have been deleted (substances severely restricted under Regulation (EU) No 850/2004 – substances as persistent organic pollutants). Note: Regulation (EC) No 850/2004 is repealed with Regulation (EU) No 2020/2096.
  • Regulation (EU) No 126/2013: entry 42 has been deleted (substances severely restricted under Regulation (EU) No 519/2012 amending Regulation (EC) No 850/2004 – substances as persistent organic pollutants). Note: Regulation (EC) No 519/2012 is repealed with Regulation (EU) No 2020/2096.
  • Regulation (EU) No 2020/2096: entries 22, 67 and 68 have been deleted (substances severely restricted under Regulation (EU) No 2019/1021 on persistent organic pollutants). See Regulation (EU) No 2020/2096.

Benzidine and its salts

EC No.: - CAS No.: -
Entry no.
First published

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Group members
This group of substance has the following member substances:
Results list is empty
Name EC / List no. CAS no. Association
Salts of benzidine - - Expert judgement (ECHA)
Benzidine 202-199-1 92-87-5 Expert judgement (ECHA)
Tetrasodium 3,3'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonate] 200-786-7 72-57-1 Expert judgement
3,3'-dichlorobenzidine 202-109-0 91-94-1 Expert judgement
3,3'-dimethoxybenzidine 204-355-4 119-90-4 Expert judgement
4,4'-bi-o-toluidine 204-358-0 119-93-7 Expert judgement
Disodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis(4-aminonaphthalene-1-sulphonate) 209-358-4 573-58-0 Expert judgement
4,4'-bi-o-toluidine dihydrochloride 210-322-5 612-82-8 Expert judgement
3,3'-dichlorobenzidine dihydrochloride 210-323-0 612-83-9 Expert judgement
Disodium 4-amino-3-[[4'-[(2,4-diaminophenyl)azo][1,1'-biphenyl]-4-yl]azo]-5-hydroxy-6-(phenylazo)naphthalene-2,7-disulphonate 217-710-3 1937-37-7 Expert judgement
Disodium 5-[[4'-[(1-amino-4-sulphonato-2-naphthyl)azo][1,1'-biphenyl]-4-yl]azo]salicylate 219-387-4 2429-79-0 Expert judgement
Tetrasodium 5-[[4'-[[2,6-diamino-3-[[8-hydroxy-3,6-disulphonato-7-[(4-sulphonato-1-naphthyl)azo]-2-naphthyl]azo]-5-tolyl]azo][1,1'-biphenyl]-4-yl]azo]salicylate 219-390-0 2429-81-4 Expert judgement
Disodium 5-[[4'-[(7-amino-1-hydroxy-3-sulphonato-2-naphthyl)azo][1,1'-biphenyl]-4-yl]azo]salicylate 219-391-6 2429-82-5 Expert judgement
Disodium 4-amino-3-[[4'-[(2,4-diamino-5-methylphenyl)azo][1,1'-biphenyl]-4-yl]azo]-5-hydroxy-6-(phenylazo)naphthalene-2,7-disulphonate 219-392-1 2429-83-6 Expert judgement
Disodium 5-[[4'-[(2-amino-8-hydroxy-6-sulphonato-1-naphthyl)azo][1,1'-biphenyl]-4-yl]azo]salicylate 219-393-7 2429-84-7 Expert judgement
Tetrasodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonate] 220-012-1 2602-46-2 Expert judgement
Disodium 5-[[4'-[[2,4-dihydroxy-3-[(4-sulphonatophenyl)azo]phenyl]azo][1,1'-biphenyl]-4-yl]azo]salicylate 220-768-2 2893-80-3 Expert judgement
Disodium 5-[[4'-[[1-hydroxy-7-(phenylamino)-3-sulphonato-2-naphthyl]azo][1,1'-biphenyl]-4-yl]azo]salicylate 222-450-9 3476-90-2 Expert judgement
Disodium 8-[[4'-[(4-ethoxyphenyl)azo][1,1'-biphenyl]-4-yl]azo]-7-hydroxynaphthalene-1,3-disulphonate 222-560-7 3530-19-6 Expert judgement
Disodium 7-hydroxy-8-[[4'-[[4-[[(p-tolyl)sulphonyl]oxy]phenyl]azo][1,1'-biphenyl]-4-yl]azo]naphthalene-1,3-disulphonate 222-655-3 3567-65-5 Expert judgement
Disodium 4-amino-5-hydroxy-3-[[4'-[(4-hydroxyphenyl)azo][1,1'-biphenyl]-4-yl]azo]-6-(phenylazo)naphthalene-2,7-disulphonate 222-835-1 3626-28-6 Expert judgement
Disodium 5-[[4'-[[2,4-diamino-5-[(4-sulphophenyl)azo]phenyl]azo][1,1'-biphenyl]-4-yl]azo]salicylate 223-294-4 3811-71-0 Expert judgement
Disodium 4-amino-5-hydroxy-6-[[4'-[(4-hydroxyphenyl)azo][1,1'-biphenyl]-4-yl]azo]-3-[(4-nitrophenyl)azo]naphthalene-2,7-disulphonate 224-376-2 4335-09-5 Expert judgement
Trisodium 5-[[4'-[[8-amino-1-hydroxy-7-[(p-nitrophenyl)azo]-3,6-disulphonato-2-naphthyl]azo]-4-biphenyl]azo]salicylate 226-545-6 5422-17-3 Expert judgement
Disodium 5-[[4'-[[2,6-diamino-3-methyl-5-[(4-sulphonatophenyl)azo]phenyl]azo][1,1'-biphenyl]-4-yl]azo]-3-methylsalicylate 228-829-5 6360-54-9 Expert judgement
Hexasodium 5,5'-[(3,7-disulphonato-1,5-naphthylene)bis[azo(6-hydroxy-3,1-phenylene)azo[6(or 7)-sulphonato-4,1-naphthylene]azo[1,1'-biphenyl]-4,4'-diylazo]]bis(salicylate) 232-397-3 8014-91-3 Expert judgement
Disodium 5-[[4'-[[4,5-dihydro-3-methyl-5-oxo-1-(4-sulphonatophenyl)-1H-pyrazol-4-yl]azo][1,1'-biphenyl]-4-yl]azo]salicylate 236-106-0 13164-93-7 Expert judgement
Disodium [5-[[4'-[[2,6-dihydroxy-3-[(2-hydroxy-5-sulphophenyl)azo]phenyl]azo][1,1'-biphenyl]-4-yl]azo]salicylato(4-)]cuprate(2-) 240-221-1 16071-86-6 Expert judgement
Benzidine sulphate 244-236-4 21136-70-9 Expert judgement
Benzidine dihydrochloride 208-519-6 531-85-1 Expert judgement
[[1,1'-biphenyl]-4,4'-diyl]diammonium sulphate 208-520-1 531-86-2 Expert judgement
2,[?]-Naphthalenedisulfonic acid, 4-[[][[]4-[[](4-amino-1-naphthalenyl)azo]-1-naphthalenyl]azo]-, disodium salt 616-837-5 8004-59-9 Expert judgement
Benzidine acetate 252-984-8 36341-27-2 Expert judgement
Benzidine, hydrochloride - 14414-68-7 Expert judgement
Disodium 4,4'-diaminobiphenyl-2,2'-disulfonate - 27336-24-9 Expert judgement
1,1'-Biphenyl-4,4'-diamine, monoperchlorate - 29806-76-6 Expert judgement
[1,1'-Biphenyl]-4,4'-diamine, perchlorate - 38668-12-1 Expert judgement
Benzidine diperchlorate - 41195-21-5 Expert judgement
(1,1'-Biphenyl)-4,4'-diamine, dihydrofluoride - 41766-73-8 Expert judgement
(1,1'-Biphenyl)-4,4'-diamine, monoacetate - 52754-64-0 Expert judgement
(1,1'-Biphenyl)-ar,ar',4,4'-tetramine - 66836-18-8 Expert judgement
benzidine, phosphate (1:1) - 66907-22-0 Expert judgement
Nickel(2+), ((1,1'-biphenyl)-4,4'-diamine-N)- - 67632-50-2 Expert judgement
(1,1'-Biphenyl)-4,4'-diamine, dihydriodide - 75534-79-1 Expert judgement
(1,1'-Biphenyl)-4,4'-diamine, monohydrochloride - 75752-15-7 Expert judgement
benzidine, mono(2-hydroxy-3,5-dinitrobenzoate) - 78577-03-4 Expert judgement
benzidine, mono(3,5-dinitrobenzoate) - 78577-08-9 Expert judgement
benzidine, bis(2-hydroxy-3,5-dinitrobenzoate) - 92415-34-4 Expert judgement
benzidine, bis(3,5-dinitrobenzoate) - 92415-52-6 Expert judgement
1,3,6-Naphthalenetrisulfonic acid, 8-hydroxy-7-((4'-((2-hydroxy-1-naphthalenyl)azo)-(1,1'-biph 613-540-2 6426-67-1 Expert judgement
[2,2'-dichloro[1,1'-biphenyl]-4,4'-diyl]diammonium sulphate 274-338-4 70146-07-5 Expert judgement
Dipotassium O,O'-(4,4'-diaminobiphenyl-3,3'-ylene)diglycollate 277-771-7 74220-10-3 Expert judgement

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