Registration Dossier
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EC number: 442-450-4 | CAS number: -
Bioaccumulation: terrestrial
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The bioacummulation potential was assessed in an ADME study in rats (please refer to section 7.1.1). In this study, male and female rats were administered test item radiolabelled either at the MOH or the TBPH moiety. The major part of the administered dose (>90%) was excreted via the faeces. This was observed for both dose groups (10 and 1000 mg/kg bw/day). 0.065 - 0.27% of the dose were found in the organs, tissues, carcass and the content of the gastrointestinal tract. The highest amounts were found in the adrenal glands, liver, thyroids, ovaries and in fat. The major excretion route was via the faeces (90.5 - 101% of the dose). There was no difference between males and females. Urinary excretion accounted for ≤ 1.77% of the dose. More than 90% of the dose was excreted within 48 h post dosing. Therefore, the terrestrial bioaccumulation potential of the test item could not be confirmed.
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