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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD guideline 431
Deviations:
no
Principles of method if other than guideline:
Test item and reference substance is applied to 3-D human skin models (EPI-200). Thereafter, cell viability is measured by means of MTT assay.
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1

Test system

Details on study design:
The corrosive potential of T-126 was investigated according to OECD 431. An amount of 25 mg T-126 and 25 µl water was applied to 3-D human skin models (EPI-200).

Results and discussion

In vitro

Results
Irritation / corrosion parameter:
other: other: in vitro assay; cell viability (MTT assay)
Value:
ca. 2.25
Remarks on result:
other:
Remarks:
Time point: 3 min and 1 hr. Reversibility: other: not relevant as in vitro assay has been done. Remarks: OECD 431. (migrated information)

In vivo

Irritant / corrosive response data:
After termination of a 3-min and a 1-hr period cell viability was measured: 94% after 3 min - 93% after 1 hr as compared to controls. Classification: non-corrosive

Applicant's summary and conclusion

Conclusions:
T-126 is non-corrosive.