Registration Dossier
Registration Dossier
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EC number: 402-140-1 | CAS number: 17865-32-6 CHMMS; CHMS; DYNASYLAN 9407; Z-6187
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance has no ionic structure
Reference
Description of key information
Dissociation constant [cyclohexyl(dimethoxy)methylsilane]: Not relevant
Dissociation constant [silanol hydrolysis product]: ca. 12
Key value for chemical safety assessment
Additional information
The requirement to test the substance for dissociation constant is waived because there are no ionisable groups within the relevant environmental pH range. The substance will hydrolyse moderately rapidly in contact with water. The hydrolysis products are cyclohexylmethylsilanediol and methanol.
There are no reliable measured data for the dissociation constant of cyclohexylmethylsilanediol. The typical dissociation constants for the hydroxyl protons of silanediols are available from studies in other silanediols. It is appropriate to read-across dissociation constant data for cyclohexylmethylsilanediol from dimethylsilanediol. This suggests that silanols are not expected to undergo significant dissociation within the range of pH relevant in the environment or in vivo. Dimethylsilanediol is reported in a secondary source to have a first dissociation constant of 11.9.
Additional information is given in a supporting report (PFA 2013b) attached in Section 13.
Reference:
PFA (2013b). Peter Fisk Associates, Dissociation constant Analogue report, PFA.300.001.001
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