Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 266-045-5 | CAS number: 65997-16-2 High-Alumina cement is a mixture of chemical substances produced by burning or sintering at high temperature (greater than 1200°C (2192°F)) raw materials which are predominantly calcium carbonate, aluminium oxide, silica, and iron oxide. The chemical substances which are manufactured are confined in a crystalline mass. This category includes all of the chemical substances specified below when they are intentionally manufactured in the production of high-alumina cement. The primary members of this category are CaAl2O4, Ca4Al2Fe2O10, Ca12Al14O33, and Ca2SiO4. Other compounds listed below may also be included in the combination with these primary substances.@CaAl4O7@Ca2Al2SiO7@CaAl12O19@Ca4Al6SO16@Ca3Al2O6.@Ca12Al14Cl@CaO@Ca12Al14F2@Ca3SiO5@Ca6Al4Fe2.@Ca2Fe2O5.
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Remarks:
- combined repeated dose and carcinogenicity
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Recommendation from the Scientific Committee on Occupational Exposure Limits for Calcium oxide (CaO) and calcium hydroxide (Ca(OH)2)
- Author:
- Scientific Committee on Occupational Exposure Limits
- Year:
- 2 008
- Bibliographic source:
- SCOEL/SUM/137, February 2008
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other: Repeated studies in human
- GLP compliance:
- no
Test material
- Reference substance name:
- Calcium oxide
- EC Number:
- 215-138-9
- EC Name:
- Calcium oxide
- Cas Number:
- 1305-78-8
- IUPAC Name:
- oxocalcium
- Reference substance name:
- Calcium dihydroxide
- EC Number:
- 215-137-3
- EC Name:
- Calcium dihydroxide
- Cas Number:
- 1305-62-0
- IUPAC Name:
- calcium dihydroxide
- Reference substance name:
- Portland cement
- IUPAC Name:
- Portland cement
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- other: Human
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 1 mg/m³ air
- Based on:
- test mat.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The Scientific Committee on Occupational Exposure Limits defined an 8 hour TWA (Time Weighted Average) for Calcium hydroxide of 1 mg/m3 with a STEL (Short Term Exposure Limit) of 4 mg/m3 for 15 minutes.
This leads to an OEL for CAHC of 2.5 mg/m³ with a STEL of 10 mg/m³ - Executive summary:
The effects of Calcium hydroxide are considered to be limited to the external surface of the body and no systemic effects are foreseen.Assuming an exposure level of 1 mg/m3and an inhalation of 10 m3of air during an 8-hour workday, this would result in an inhaled dose of 5.4 mg calcium per day. Overall, the occupational exposure would only increase the body burden of calcium to a negligible extent as the Tolerable Upper Intake Level is 2,500 mg of calcium per day.
At low-level exposures, sensory irritation and a decrease of the lung function parameters at long-term exposures are considered to be the critical effects.From a well conducted acute human study with Calcium oxide, sensory irritation is expected to be avoided at 1 mg/m3of respirable dust. No relevant respiratory effects were seen at an exposure level of 1 mg/m3of total dust among kiln workers producing. One mg of Calcium hydroxide per m3 is therefore obviously protective against adverse effects from long-term exposure to Calcium hydroxide and this concentration is supported by data from exposure to cement dust that has a similar alkalinity.
The Scientific Committee on Occupational Exposure Limits defined an 8 hour TWA (Time Weighted Average) for Calcium hydroxide of 1 mg/m3 with a STEL (Short Term Exposure Limit) of 4 mg/m3 for 15 minutes.
This leeds to an OEL for CAHC of 2.5 mg/m³ with a STEL of 10 mg/m³
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