Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 266-045-5 | CAS number: 65997-16-2 High-Alumina cement is a mixture of chemical substances produced by burning or sintering at high temperature (greater than 1200°C (2192°F)) raw materials which are predominantly calcium carbonate, aluminium oxide, silica, and iron oxide. The chemical substances which are manufactured are confined in a crystalline mass. This category includes all of the chemical substances specified below when they are intentionally manufactured in the production of high-alumina cement. The primary members of this category are CaAl2O4, Ca4Al2Fe2O10, Ca12Al14O33, and Ca2SiO4. Other compounds listed below may also be included in the combination with these primary substances.@CaAl4O7@Ca2Al2SiO7@CaAl12O19@Ca4Al6SO16@Ca3Al2O6.@Ca12Al14Cl@CaO@Ca12Al14F2@Ca3SiO5@Ca6Al4Fe2.@Ca2Fe2O5.
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- other: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02. Jul. 2010 - 05.Jul. 2010
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline Part 431 (In vitro Skin Corrosion: Human Skin Model Test"
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Cement, alumina, chemicals
- EC Number:
- 266-045-5
- EC Name:
- Cement, alumina, chemicals
- Cas Number:
- 65997-16-2
- Molecular formula:
- 3CaO.Al2O3.CaCO3.11H2O
- IUPAC Name:
- Cement, alumina, chemicals
Constituent 1
Test animals
- Species:
- other: EpiDerm tissue
- Strain:
- other: Epi-200-Kit
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: not applicable
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: EpiDerm tissues with H2O demin. as negative control; EpiDerm tissues with potassium hydroxid solution as posive control
- Duration of treatment / exposure:
- The human skin model EpiDerm was treated with CAHC for three minutes and one hour, respectively.
- Observation period:
- Three minutes respectively one hour.
- Number of animals:
- Two EpiDerm tissues were jused for the "three minute" experiment and two were jused for the "one hour" experiment.
Two EpiDerm tissues were jused as negative control, two tissues as positive control.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Formazan Production
- Basis:
- mean
- Time point:
- other: 3 minutes
- Score:
- ca. 100
- Reversibility:
- no data
- Irritation parameter:
- other: Formazan Production
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- ca. 98
- Reversibility:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- other: not corrosive
- Remarks:
- Criteria used for interpretation of results: OECD GHS
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