Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
other: All information in this endpoint has been provided by the ECHA using the 12 year rule, this data is not owned by the registrant . The reliability is estimated to be at level 2 at a minimum.
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
All information in this endpoint has been provided by the ECHA using the 12 year rule, data are not owned by the registrant. The reliability is estimated to be at level 2 at a minimum. Therefore the reliability statement below can be used: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of relevant results.

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Guideline:
other: Code of federal Regulations, Title 16, section 1500.3, Federal hazardous substances Act Regulations, pp. 325-342 NIH publication number 86-23
Deviations:
not specified
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
424-240-4
EC Name:
-
Cas Number:
96478-09-0
Molecular formula:
C18 H17 N3 O3
IUPAC Name:
2-[3-(2H-1,2,3-benzotriazol-2-yl)-4-hydroxyphenyl]ethyl 2-methylprop-2-enoate

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
This information was not provided in the migrated SNIF dossier (SNIF # 001-3.0.10-01) provided by ECHA

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
corn oil
Details on oral exposure:
This information was not provided in the migrated SNIF dossier (SNIF # 001-3.0.10-01) provided by ECHA
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
5 males and 5 females were dosed at the 5000 mg/kg bw dose level.
Control animals:
not specified
Details on study design:
This information was not provided in the migrated SNIF dossier (SNIF # 001-3.0.10-01) provided by ECHA
Statistics:
This information was not provided in the migrated SNIF dossier (SNIF # 001-3.0.10-01) provided by ECHA

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No deaths occured during the study
Clinical signs:
other: No clinical signs were observed during the study
Gross pathology:
No necropsy was performed

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The test material has been determined to have an LD 50 of > 5000 mg/kg bw
Executive summary:

The test material has been determined to have an LD 50 of > 5000 mg/kg bw, under the conditions of this study.