Ammonium sulfide ((NH4)2(Sx))

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro gene mutation study in bacteria

Remarks:

Type of genotoxicity: gene mutation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: basic information given

Data source

Reference

Reference Type:

publication

Title:

Study of the genotoxic potential of 48 inorganic derivatives with the SOS chromotest.

Author:

Olivier, P.; Marzin, D.

Year:

1987

Bibliographic source:

Mutation Research 189, 263 - 269

Materials and methods

Principles of method if other than guideline:

The SOS Chromotest was performed as described by Quillardet et al. (1982), and adapted by Marzin et al. (1986).

GLP compliance:

no

Type of assay:

other: SOS chromotest

Test material

Test material information

Constituent 1

Reference substance name:

Ammonium sulphide

EC Number:

235-223-4

EC Name:

Ammonium sulphide

Cas Number:

12135-76-1

IUPAC Name:

thioxoammonium

Details on test material:

Name of the test substance used in the publication: ammonium sulfide

Method

Target gene:

E. coli

Species / strain

Species / strain / cell type:

E. coli, other: PQ37 and PQ35

Metabolic activation:

with and without

Metabolic activation system:

rat liver S-9 mix

Test concentrations with justification for top dose:

0.9 - 9 mM/ml

Vehicle / solvent:

DMSO

Results and discussion

Test results

Species / strain:

E. coli, other: PQ37 and PQ35

Metabolic activation:

with and without

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

not specified

Vehicle controls validity:

valid

Untreated negative controls validity:

valid

Positive controls validity:

valid

Remarks on result:

other: all strains/cell types tested

Remarks:

Migrated from field 'Test system'.