Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 611-033-0 | CAS number: 536759-91-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Administrative data
First-aid measures
Eye contact: Rinse immediately with plenty of water for at least 15 minutes. Keep eye wide open while
rinsing. Obtain medical attention.
Skin contact: Take off contaminated clothing and shoes immediately. Wash off immediately with plenty
of water for at least 15 minutes. Obtain medical attention. Discard contaminated clothing
or wash before re-use.
Inhalation: Move to fresh air. Oxygen or artificial respiration if needed. Obtain medical attention.
Ingestion: Do NOT induce vomiting. Consult a physician if necessary. Never give anything by
mouth to an unconscious person.
Notes to Physician: Material not fully tested. .
Medical Surveillance: Employees who are pregnant, are breast-feeding, or who are concerned with other
reproductive issues should be encouraged to consult with the occupational health physician
monitoring worker's health.
Fire-fighting measures
Flammable Properties: Not readily combustible
Extinguishing Media: Suitable extinguishing media: Dry chemical, Water spray, Foam
Unsuitable extinguishing media: Do NOT use water jet.
Protection of Firefighters: Specific hazards: Not available. Protective equipment: Use personal protective equipment. In the event of fire, wear selfcontained breathing apparatus.
Hazardous Combustion Products: carbon oxides (COx), nitrogen oxides (NOx)
Other information: Avoid generating dust; fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. Decontaminate protective clothing and equipment before reuse.
Accidental release measures
Personal precautions: Refer to protective measures listed in sections 7 and 8. Use personal protective equipment. Examples include tightly fitting safety goggles, disposable lab coat of low permeability with cuffs, double gloves and shoe covers. Wear respiratory protection. Depending on the nature of the spill (quantity and extent of spill) additional protective clothing and equipment such as a self-contained breathing apparatus may be needed.
Environmental precautions: Prevent release to drains and waterways. Prevent release to the environment.
Containment Methods Wet down any dust to prevent generation of aerosols, if appropriate. Cover with suitable material.
Cleanup Methods: Spill prevention procedures and a spill response procedure should be implemented. Contain and collect spillage and place in container for disposal according to local regulations (see Section 13). Clean spill area with a deactivating solution (if available) followed by detergent and water after spill pick-up. Handle waste materials, including gloves, protective clothing, contaminated spill cleanup material, etc., as appropriate for
chemically and pharmacologically similar materials.
Other information Dust deposits should not be allowed to accumulate on surfaces, as these may form an explosive mixture if they are released into the atmosphere in sufficient concentration. Avoid dispersal of dust in the air (i.e., clearing dust surfaces with compressed air). Nonsparking tools should be used.
Handling and storage
Handling Precautions: Minimize dust generation and accumulation. Routine housekeeping should be instituted to ensure that dusts do not accumulate on surfaces. Dry powders can build static electricity charges when subjected to the friction of transfer and mixing operations. Provide adequate precautions, such as electrical grounding and bonding, or inert atmospheres. Do not use in areas without adequate ventilation. Avoid exposure - obtain special instructions before use. Avoid formation of dust and aerosols. Keep away from heat and sources of ignition. Prevent release to drains and waterways.
Container Requirements: Store in sturdy containers appropriate to maintain the integrity of this material for its intended use.
Storage Conditions: Store at room temperature. Protect against light. Keep away from heat, sparks and flames.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- Not listed
Shippingopen allclose all
SpecialProvisionsopen allclose all
Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- Not listed
Shippingopen allclose all
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- Not listed
Shippingopen allclose all
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- Not listed
Shippingopen allclose all
Remarksopen allclose all
SpecialProvisionsopen allclose all
Exposure controls / personal protection
Recommended Industrial Hygiene Monitoring Methods: A specific exposure sampling method is not available. Contact the Bristol-Myers Squibb
AIHA accredited Industrial Hygiene Laboratory at (USA) 732-227-6338. General - The health hazard risk of handling this material is dependent on many factors, including physical form, % API in material being handled, duration and frequency of process task, and effectiveness of controls. If it is necessary to handle this compound outside of engineering controls, an exposure risk assessment should be conducted and procedures documented by a qualified EHS professional.
Engineering Controls and Ventilation:
Use process enclosures, containment technology, or other engineering controls to keep
airborne levels below recommended exposure limit. When handling quantities up to 3
milligrams, a standard laboratory with general laboratory dilution ventilation (e.g. 6-12 air
changes per hour) is appropriate. When handling quantities up to 1 kilogram, work in either a
standard laboratory (<500 g) or designated laboratory (500 g to <1 kg) using a fume hood,
biological safety cabinet(Class II, Type A2 with thimble connection, B1, or B2)or approved
vented enclosure. HEPA filtered exhaust preferred for fume hoods containing particularly
"dusty" operations. Quantities exceeding 1 kilogram should be handled in a designated
laboratory or containment facility using appropriate containment technology. A laminar
flow/powder containment booth or appropriate isolation technology should be considered for
handling more than 1 kilogram of active compound. HEPA filtered exhaust preferred. For
manufacturing and pilot plant operations, barrier/containment technology and direct coupling
(totally enclosed processes that create a barrier between the equipment and the room) with use
of double or split butterfly valves, hybrid unidirectional airflow/local exhaust ventilation
solutions (e.g. powder containment booth) should be used. Glove bags, isolator/glove box
systems are optional. HEPA filtration of exhaust from dry product handling areas is required.
It is recommended that all dust control equipment such as local exhaust ventilation and
material transport systems involved in handling of this product contain explosion relief vents
or an explosion suppression system or an oxygen deficient environment. Ensure that dusthandling
systems (such as exhaust ducts, dust collectors, vessels, and processing equipment)
are designed in an manner to prevent the escape of dust into the work area (i.e., there is no
leakage from the equipment). Use only appropriately classified electrical equipment and
powered industrial trucks.
Respiratory protection
Use and selection of respiratory protection is based upon engineering controls in use and
potential for aerosol generation. When engineering controls are not sufficient control
exposure, wear an approved respirator with NIOSH Class 100 or high efficiency particulate
(HEPA) filters or cartridges (EN 140/EN 136) when exposures are up to 10 times the exposure
control guideline. Wear a loose-fitting (Tyvek or helmet type) HEPA powered-air purifying
respirator (PAPR) (EN 12941) when exposures are 10-25 times the exposure control
guideline. Wear a full facepiece negative pressure respirator with Class 100 or HEPA filters
(EN 136) when exposures are 25-50 times the exposure control guideline. Wear a tightfitting,
full facepiece HEPA PAPR (EN 12942) when exposures are 50-100 times the exposure
control guideline. Wear a hood-shroud HEPA PAPR (EN 12941) or full facepiece supplied
air respirator (EN 139) operated in a pressure demand or other positive pressure mode when
exposures are 100-1000 times the exposure control guideline.
Eye protection Safety glasses with side-shields are recommended (EN 166). Face shields or chemical safety
goggles (EN 166) may be required if splash potential exists or if corrosive materials are
present. Note: Choice of eye protection may be influenced by the type of respirator which is
selected.
Hand protection
Wear gloves at all times when handling containers, including when unpacking, inspecting or
transporting within a facility. Impervious gloves are recommended. (EN 420, EN 374).
Double gloving for all manufacturing personnel potentially in direct contact with the
compound should be considered. If material is handled in solution, the solvent should also be
considered when selecting protective clothing material.
Skin and body protection
Wear a laboratory coat (EN 340) when handling quantities up to 500 grams. For quantities up
to 1 kilogram, wear disposable laboratory coat (EN 340) or coverall of low permeability (EN
1149-1) . For quantities over 1 kilogram and manufacturing operations, wear disposable
coverall of low permeability (EN 1149-1) and disposable shoe covers.
Hygiene Wash hands and face before breaks and immediately after handling the product.
Environmental exposure controls
Prevent release to drains and waterways.
Stability and reactivity
Stability
Chemical Stability: Stable under normal conditions.
Conditions to avoid: Not available
Materials to avoid: Not available
Hazardous decomposition products: Hazardous decomposition products formed under fire conditions.: carbon oxides (COx), nitrogen oxides (NOx)
Hazardous reactions: Hazardous polymerisation does not occur.
Sensitivity to static discharge/Dust exp.
Explosion Severity Factor: 222 m.b_/s St2 Material exhibits strong explosion characteristics if ignited as a dust cloud.
Minimum Ignition Energy: > 10 - < 25 mJ Material is very susceptible to igniting as a dust cloud under certain conditions due to low minimum ignition energy.
Volume Resistivity (ambient): 170.0000E+12 ohm.m Material is highly susceptible to accumulating static charges during processing.
Charge decay time (ambient): 5.5 H
Ignition temperature: > 490 - < 510 °C
Layer decomposition: No exotherm observed.
Summary Statements
Powder handling equipment such as dust collectors, dryers, and mills may require additional
protective measures (e.g. explosion venting, inerting, etc.). Provide suitable bonding and
grounding for containers, personnel, and process equipment to control static charges. NOTE:
THIS DATA IS REPRESENTATIVE FOR THE SPECIFIC PROCESS STATE OF THE MATERIAL NOTED ON THIS SDS ONLY. Dust explosion severity risk can vary upon processing or environmental change (e.g. milling, micronizing, sieving, blending or heating can increase the risk of explosion), and may require additional dust explosion testing.
Disposal considerations
Advice On Disposal And Packaging
Disposal should be in accordance with applicable regional, national and local laws and regulations. Local regulations may be more stringent than regional or national requirements. This information presented only applies to the material as supplied.
Other information Disposal by incineration is recommended
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
