Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 420-380-5 | CAS number: 136465-81-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31st August 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions. This study was performed in compliance with the GLP regulations. Only memorandum available; no full study report.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- Deviations:
- not specified
- Principles of method if other than guideline:
- No further details were provided.
- GLP compliance:
- yes
Test material
- Reference substance name:
- PTH-Decahydroamide
- IUPAC Name:
- PTH-Decahydroamide
- Reference substance name:
- Ro 31-9373/000
- IUPAC Name:
- Ro 31-9373/000
- Details on test material:
- No further details were provided.
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No further details were provided.
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- No further details were provided.
Test solutions
- Vehicle:
- not specified
- Details on test solutions:
- No further details were provided.
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- No further details were provided.
Study design
- Test type:
- not specified
- Water media type:
- not specified
- Remarks on exposure duration:
- No further details were provided.
- Post exposure observation period:
- No further details were provided.
Test conditions
- Hardness:
- No further details were provided.
- Test temperature:
- No further details were provided.
- pH:
- No further details were provided.
- Dissolved oxygen:
- No further details were provided.
- Salinity:
- No further details were provided.
- Nominal and measured concentrations:
- No further details were provided.
- Details on test conditions:
- No further details were provided.
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 4.8 mg/L
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 46 mg/L
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 74 mg/L
- Basis for effect:
- growth rate
- Details on results:
- Since this concentration was below the detection limit of PTH-decahydroamide (Ro 31-9373/000) in water samples, no actual concentration could be determined.
- Results with reference substance (positive control):
- No further details were provided.
- Reported statistics and error estimates:
- No further details were provided.
Any other information on results incl. tables
No further details were provided.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- PTH-Decahydroamide (Ro 31-9373/000) inhibited cell growth and reduced growth rate of Scenedesmus subspicatus significantly under the conditions of the present study at nominally 10 mg/l and higher. The inhibition rates were estimated for both the algal biomass b and the growth rate R after 72 hours test duration; based on nominal concentrations.
EbC50 (0-72 h) 46 mg/l
ERC50 (0-72 h) 74 mg/l
The NOEC was 4.8 mg/l for both cell growth inhibition and growth rate reduction when based on nominal concentrations. Since this concentration was below the detection limit of PTH-decahydroamide (Ro 31-9373/000) in water samples, no actual concentration could be determined. - Executive summary:
The study procedure described was performed on the basis of EC directive 92/69/EEC, C. 3 (1992) and OECD guideline No. 201 (1984).
PTH-Decahydroamide (Ro 31-9373/000) inhibited cell growth and reduced growth rate of Scenedesmus subspicatus significantly under the conditions of the present study at nominally 10 mg/l and higher. The inhibition rates were estimated for both the algal biomass b and the growth rate R after 72 hours test duration; based on nominal concentrations.
EbC50 (0-72 h) 46 mg/l
ERC50 (0-72 h) 74 mg/l
The NOEC was 4.8 mg/l for both cell growth inhibition and growth rate reduction when based on nominal concentrations. Since this concentration was below the detection limit of PTH-decahydroamide (Ro 31-9373/000) in water samples, no actual concentration could be determined.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
