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EC number: 420-380-5 | CAS number: 136465-81-1
Surface tension
Administrative data
- Endpoint:
- surface tension
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Modern study peformed under GLP and using the recommended method, EC directive 92/69/EEC, A.5.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.5 (Surface Tension)
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
- Type of method:
- ring method
Test material
- Reference substance name:
- PTH-decahydroamide
- IUPAC Name:
- PTH-decahydroamide
- Reference substance name:
- Ro 31-9373/000
- IUPAC Name:
- Ro 31-9373/000
- Details on test material:
- The test material received from F. Hoffmann-La Roche Ltd was a white solid powder from lot no. 25927 with a purity of 99.8%.
Constituent 1
Constituent 2
Results and discussion
Surface tension
- Surface tension:
- 51.9 mN/m
- Temp.:
- 20 °C
- Conc.:
- 1 g/L
Any other information on results incl. tables
The gauging factor (C) was determined to be 1.01. Four consecutive measurements were performed on the 1.0 g/L solution of PTH-Decahydroamide and the gauging factor applied to get the corrected surface tension. A constant value of 51.9 mN/m at 20 °C was determined for the corrected surface tension.
Equilibration Time at 20 ⁰C (minutes) |
Measured Surface Tension (mN/m) |
Corrected Surface Tension (mN/m) |
10 |
52.65 |
51.9 |
15 |
52.65 |
51.9 |
25 |
52.65 |
51.9 |
40 |
52.65 |
51.9 |
Average |
51.9 |
|
Std. Dev. |
0.0 (n=4) |
|
Based on the criteria as outlined in the EC guideline A.5, it is concluded that PTH-decahydroamide (Ro 319373/000) should be regarded as a surface active material.
Applicant's summary and conclusion
- Conclusions:
- The surface tension of a 1 g/L solution of PTH-decahydroamide (Ro 31 -9373/000) was determined to be 51.9 mN/m. Based on the criteria as outlined in the EC guideline A.5, it was concluded that PTH-decahydroamide (Ro 319373/000) should be regarded as a surface active material.
- Executive summary:
The determination of the surface tension of an aqueous solution of PTH-decahydroamide (Ro 31 -9373/000) was performed using EC directive 92/69/EEC, A.5 (1992).
The surface tension of a 1 g/L solution of PTH-decahydroamide (Ro 31 -9373/000) was determined to be 51.9 mN/m. Based on the criteria as outlined in the EC guideline A.5, it was concluded that PTH-decahydroamid (Ro 319373/000) should be regarded as a surface active material.
This conclusion is in agreement with the foaming phenomenon observed when PTH-decahydroamide (Ro 31 -9373/000) is strongly agitated in aquoeus solutions.
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