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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non guideline and non GLP study. Basic data given. Limitations in design and reporting.

Data source

Reference
Reference Type:
publication
Title:
Effect on the organism of rare, dispersed, and other metals, and their compounds used in industry: zirconium
Author:
Mogilevskaya, O. Ya.
Year:
1968
Bibliographic source:
National Science Foundation: Toxicology of rare metals, Washington D.C., 1967, pg 44

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Only five animals per dose were exposed two to three times to the dust of zirconium.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Zirconium
EC Number:
231-176-9
EC Name:
Zirconium
Cas Number:
7440-67-7
IUPAC Name:
zirconium(2+)

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
nose only
Vehicle:
not specified
Details on inhalation exposure:
Test substance was applied two or three times.
Analytical verification of test atmosphere concentrations:
not specified
Remarks on duration:
no data
Concentrations:
2 - 3 mg/L
No. of animals per sex per dose:
5 animals per dose
Control animals:
yes
Details on study design:
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: concentration of Zr
Effect level:
> 2 - <= 3 mg/L air
Based on:
test mat.
Mortality:
No mortality was observed.
Clinical signs:
other: No clinical signs of toxicity were observed.
Body weight:
No data
Gross pathology:
Histological examinations of the organs did not reveal any treatment-related findings. In the lungs considerable pulmonary congestions were detected.

Applicant's summary and conclusion