Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
discriminating conc.
22 900 mg/m³ air

Additional information

Acute toxicity: oral - waived as inhalation data are avaiable.

Acute toxicity: dermal - waived as inhalation is the more important exposure pathway.

Acute toxicity: Inhalation

A single four hours nose-only exposure of reaction mass of DIPE and 2-methylpent-2-ene to CRL: (WI) BR rat followed by a 14-day observation period at a dose level 22.9 mg/L was not associated with any test item-related macroscopic findings.

Justification for classification or non-classification

The criteria for classification as acute toxic (inhalative) of reaction mass of DIPE and 2-methylpent-2-ene according to the Directive 67/548/EEC and Regulation (EC) 1272/2008 are not met.

Narcotic effects of reaction mass of DIPE and 2 -methylpent-2-ene

were not observed during testing of acute inhalation toxicity (nose-only) with the test item according to the OECD 403 guideline under GLP.

However, as a precautionary measure, the reaction mass is classified as R67 and Category 3 (H336) for narcotic effects according to Directive 1999/45/CE and Regulation (EC) 1272/2008 repectively due to the official classification with H336 of DIPE, a main constituent present at ca. 40%.