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Description of key information

Key value for chemical safety assessment

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
discriminating conc.
22 900 mg/m³ air

Additional information

Acute toxicity: oral - waived as inhalation data are avaiable.

Acute toxicity: dermal - waived as inhalation is the more important exposure pathway.

Acute toxicity: Inhalation

A single four hours nose-only exposure of reaction mass of DIPE and 2-methylpent-2-ene to CRL: (WI) BR rat followed by a 14-day observation period at a dose level 22.9 mg/L was not associated with any test item-related macroscopic findings.

Justification for classification or non-classification

The criteria for classification as acute toxic (inhalative) of reaction mass of DIPE and 2-methylpent-2-ene according to the Directive 67/548/EEC and Regulation (EC) 1272/2008 are not met.

Narcotic effects of reaction mass of DIPE and 2 -methylpent-2-ene

were not observed during testing of acute inhalation toxicity (nose-only) with the test item according to the OECD 403 guideline under GLP.

However, as a precautionary measure, the reaction mass is classified as R67 and Category 3 (H336) for narcotic effects according to Directive 1999/45/CE and Regulation (EC) 1272/2008 repectively due to the official classification with H336 of DIPE, a main constituent present at ca. 40%.