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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.007 mg/L
Assessment factor:
1 000
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
0.069 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.001 mg/L
Assessment factor:
10 000
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
30 mg/L
Assessment factor:
100
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
0.043 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.004 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.005 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

The reaction mass of DIPE and 2 -methylpent-2 -ene was tested for acute toxicity to daphnia, algae, fish and micro-organisms.

The EC50 value from the 3h-respiration inhibition test with sewage sludge was 3000 mg/L. The results were used in risk assessment, but are not required for classification.

The EC50 value from the 48h-daphnia test (6.9 mg/L) represented the lowest value in comparison with the 72h-ErC50 from the algae test (22 mg/L, value based on growth rate). Therefore, a 96h limit test with 10 mg/L with fish was performed to evaluate if fish were more sensitive than daphnia. As no effects were observed in the limit test, the EC50 (48h, daphnia) is the lowest value among the three species and used for risk assessment and classification. Based on this value and the lack of biodegradability, the reaction mass has to be classified as toxic to aquatic life with long lasting effects (chronic aquatic toxicity category 2; H 411 according to CLP regulation).

Comparing the test results on daphnia, algae and fish with measured or estimated data on aquatic toxicity for the known components of the reaction mass, it appears likely that a considerable portion of the ecotoxicity measured for the reaction mass is caused by 2-methylpent-2-ene and other methlypentene / methylpentane isomers. Measured and calculated literature values for DIPE are in the range of 92 - 786 mg/L (1 -4) while estimated values (Episuite, ECOSAR 2009) for 2 -methylpent-2 -ene and other methylpentene and methylpentane isomers are in the range of 2 - 7 mg/L (see CSR chapter 8).

Based on the lowest EC50 value among the species daphnia, algae and fish (lowest value 6.9 mg/L for daphnia), a PNEC was calculated for freshwater and marine water using the assessment factor method. PNECs were calculated for the other compartments from the PNEC freshwater using the equilibrium partitioning method. No PNEC oral was calculated as there is no potential for bioaccumulation.

As risk assessment indicated that risk is controlled for water, sediment, sewage treatment plant and soil no further tests on ecotoxicity are required.

(1) EPI SuiteTM (2000). Estimation Program Interface Suite, version 3.12. Syracuse Research Corporation, Syracuse, NY, USA.

(2)Veith G, Call D and Brooke L (1983). Structure-Toxicity Relationships for the Fathead Minnow, Pimephales promelas: Narcotic Industrial Chemicals.Can.J. Fish. Aquat. Sci. 40, 743-748.

(3)Geiger D, Poirier S, Brooke L and Call D (eds.) (1986). Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Vol. 3. Center forLake SuperiorEnvironmental Studies,Univ.ofWisconsin- Superior,Superior,WI,USA.

(4) HIGH PRODUCTION VOLUME (HPV) CHEMICAL CHALLENGE PROGRAM TEST PLAN For: Diisopropyl Ether (DIPE) CAS NO. 108-20-3 Prepared by: ExxonMobil Chemical Company Shell Chemical LP, December 12, 2005

Conclusion on classification

Based on the lowest EC50 value among the species daphnia, algae and fish (lowest value 6.9 mg/L for daphnia) in combination with the fact that the substance is not readily biodegradable, a classification into aquatic chronic category 2 (H411) according to the CLP regulation (corresponding to N, R51/53 under DSD) is necessary (EC50 1 - 10 mg/l).