Registration Dossier
Registration Dossier
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EC number: 408-050-9 | CAS number: 76855-69-1 4-AA; AOSA; AZETIDONE-KANEKA; GR91990X
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V, B1 bis
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- (2R,3R)-3-((R)-1-(tert-butyldimethylsiloxy)ethyl)-4-oxoazetidin-2-yl acetate
- EC Number:
- 408-050-9
- EC Name:
- (2R,3R)-3-((R)-1-(tert-butyldimethylsiloxy)ethyl)-4-oxoazetidin-2-yl acetate
- Cas Number:
- 76855-69-1
- Molecular formula:
- C13H25NO4Si
- IUPAC Name:
- (2R,3R)-3-[(1R)-1-[(tert-butyldimethylsilyl)oxy]ethyl]-4-oxoazetidin-2-yl acetate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- corn oil
- Doses:
- Main : 2000 mg/kg
- No. of animals per sex per dose:
- Preliminary sighting study: 0 (male)
Preliminary sighting study: 1 (female)
Main study: 5 male
Main study: 5 female
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 2 000 mg/kg bw
- Mortality:
- no mortality
- Clinical signs:
- other: none of the animals died. Signs of slight but not evident toxicity, including diarhoea, piloerection and upward curve of the spine, with complete recovery by day 7.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
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