Registration Dossier
Registration Dossier
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EC number: 611-756-1 | CAS number: 58861-48-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 23/06/2008 - 04/07/2008
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-(4-fluorophenyl)thiophene
- EC Number:
- 611-756-1
- Cas Number:
- 58861-48-6
- Molecular formula:
- C10H7FS
- IUPAC Name:
- 2-(4-fluorophenyl)thiophene
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The other eye of each rabbit was not treated and served as a control.
- Duration of treatment / exposure:
- 0.1 g in one eye of the rabbit
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3 rabbits
Results and discussion
Any other information on results incl. tables
I. O. Max. = 25,7
Applicant's summary and conclusion
- Interpretation of results:
- Category 2B (mildly irritating to eyes)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Eye irritation : category 2, H319 : Causes serious eye irritation.
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