Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Study period:
17/06/2008 - 22/07/2008
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Qualifier:
according to guideline
Guideline:
EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
GLP compliance:
not specified
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(4-fluorophenyl)thiophene
EC Number:
611-756-1
Cas Number:
58861-48-6
Molecular formula:
C10H7FS
IUPAC Name:
2-(4-fluorophenyl)thiophene

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
DMSO
Doses:
2000 mg/kg & 300 mg/kg
No. of animals per sex per dose:
2000 mg/kg : 6 female rats
300 mg/kg : 6 female rats

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
ca. 500 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Acute oral toxicity = category 4, H302: Harmful if swallowed.