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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
toxicity to microorganisms
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The information of this endpoint has been provided by ECHA as a result of an inquiry, thus the full access to data in the report is not accessible to the registrant. However the reliability is estimated to be at level 1: Study conducted in accordance with generally accepted scientific principles. Possible deficiencies do not affect the quality of relevant results.

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1998
Report date:
1998

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: "Biodegradation Activated Sludge Respiration Inhibition test" of Commission Directive 87/302/EEC (OEC No. 209)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
413-110-2
EC Name:
-
Cas Number:
135861-56-2
Molecular formula:
C24H30O6
IUPAC Name:
1-[2,6-bis(3,4-dimethylphenyl)-hexahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test organisms

Test organisms (species):
activated sludge

Study design

Test type:
other: aerobic
Water media type:
not specified
Limit test:
yes
Total exposure duration:
3 h

Results and discussion

Effect concentrationsopen allclose all
Duration:
3 h
Dose descriptor:
IC50
Effect conc.:
> 1 000 mg/L
Duration:
3 h
Dose descriptor:
NOEC
Effect conc.:
100 mg/L

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
There were limited data available on the details. The 3 h IC50 value of the test substance on activated sludge microbes under aerobic conditions was > 1000 mg/L and a 3 h NOEC 100 mg/L.
Executive summary:

As the study was performed under GLP and assessed by authorities, it was considered as valid. The 3 h NOEC of the test substance on the activated sludge microbes under aerobic conditions was 100 mg/L. The value was created for the chemical safety assessment, where needed, for this insoluble test substance.