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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

Description of key information

COASOL 290 PLUS is a reaction mass of dibutyl glutarate and dibutyl adipate, while COASOL is a reaction mass of the very similar isomers diisobutyl glutarate, diisobutyl succinate, and diisobutyl adipate. Thus, results from studies for COASOL are applied to COASOL 290 PLUS (read-across). No bioaccumulation studies were available for COASOL or COASOL 290 PLUS.

Key value for chemical safety assessment

Additional information

In accordance with column 2 of REACH Annex IX, the bioaccumulation testing for COASOL (required in section 9.3.2) is not proposed as the substance has a low potential for bioaccumulation.COASOL is comprised of diisobutyl esters (di-isobutyl succinate, di-isobutyl glutarate and di-isobutyl adipate), which will hydrolyze when they are taken up by an organism. This releases isobutanol and then adipic, glutaric and succinic acid, which are all endogenous in mammals. Succinic acid is a part of the citric acid cycle and so will be taken into the organisms normal metabolic processes, glutarate can be further converted into alphaketo-glutarate and enter the citric acid cycle, and adipate can be converted into a number of things, such as urea, or excreted as is. In addition, results from QSAR modelling (BCFBAF) of the individual constituents (di-isobutyl succinate, di-isobutyl glutarate and di-isobutyl adipate) using the Arnot-Gobas model, which incorporates metabolism and bioavailability of the substances, estimates BCF values for all constituents of <13 L/kg wwt. Hence, the potential for bioaccumulation is minimal and testing will be waived.