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Registration Dossier
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EC number: 203-252-1 | CAS number: 104-92-7
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The origin and hence the methodical information for the given log Pow value is not clear: In detail, it is unclear, if the log Pow value of 4-bromoanisole is an experimental value by Dunn and Johansson (1983), or if the given log Pow value is derived from the following reference C. Hansch and A. Leo, Pomona College Medicinal Cemistry Data Bank, Pomona College, Claremont, CA 91711, USA.
Data source
Reference
- Reference Type:
- publication
- Title:
- Nonadditivity of 1-Octanol/Water Partition Coefficients of Disubstituted Benzenes: An Explannation and Its Consideration in Log P Estimation
- Author:
- W. J. Dunn III and E. Johansson
- Year:
- 1 983
- Bibliographic source:
- Quant. Struct.-Act. Relat. 2, 156-163 (1983)
Materials and methods
- GLP compliance:
- not specified
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Test material form:
- not specified
- Details on test material:
- no data
Constituent 1
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 3.05
- Details on results:
- no data
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Conclusions:
- According to Dunn and Johansson (1983) the log Pow value for 4-bromoanisole is 3.05.
- Executive summary:
A log Pow value for 4-bromoanisole of 3.05 is given in Dunn and Johansson (1983). The shake-flask method was used for the experimental determination of log Pow. However, it is not clear, if the given log Pow of 4-bromoanisole is an experimental value from this publication, or if this value is from another source (see rationale for reliability inclucive deficiences). Hence, the information on the log Pow is considered as not reliable.
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