Registration Dossier
Registration Dossier
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EC number: 700-717-5 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: 4e The study did not meet current guideline requirements for OECD 405. It does, however, add weight of evidence for eye irritation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 951
- Report date:
- 1951
Materials and methods
- Principles of method if other than guideline:
- No data
- GLP compliance:
- no
Test material
- Reference substance name:
- Dichloro(dimethyl)silane
- EC Number:
- 200-901-0
- EC Name:
- Dichloro(dimethyl)silane
- Cas Number:
- 75-78-5
- Molecular formula:
- C2H6Cl2Si
- IUPAC Name:
- Dichloro(dimethyl)silane
- Details on test material:
- - Name of test material (as cited in study report): Dichlorodimethylsilane
No further details available
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 0.005 ml
- Duration of treatment / exposure:
- No data
- Observation period (in vivo):
- No data
- Number of animals or in vitro replicates:
- No data
Results and discussion
Any other information on results incl. tables
Grade >5 indicating corneal burns from 0.005 ml of test substance.
Applicant's summary and conclusion
- Conclusions:
- In a non-guideline, pre-GLP, eye irritation study (reliability score 4) 0.005 ml of dichlorodimethylsilane caused corneal burns to rabbit eyes.
- Executive summary:
In a non-guideline, pre-GLP, eye irritation study (reliability score 4) 0.005 ml of dichlorodimethylsilane caused corneal burns to rabbit eyes.
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