Registration Dossier
Registration Dossier
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EC number: 206-575-6 | CAS number: 355-04-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Remarks:
- other: Using SkinEthic
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage)
- Version / remarks:
- The guideline is not cited, but its methodology is followed.
- Principles of method if other than guideline:
- SkinEthic exposed to subject material for 10 minutes. Viability of cells determined by their ability to reduce MTT.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,1,1,2,2,3,3,4,5,5,5-undecafluoro-4-(trifluoromethyl)pentane
- EC Number:
- 206-575-6
- EC Name:
- 1,1,1,2,2,3,3,4,5,5,5-undecafluoro-4-(trifluoromethyl)pentane
- Cas Number:
- 355-04-4
- Molecular formula:
- C6F14
- IUPAC Name:
- 1,1,1,2,2,3,3,4,5,5,5-undecafluoro-4-(trifluoromethyl)pentane
Constituent 1
Results and discussion
In vitro
Results
- Irritation parameter:
- other: Relative mean viability
- Value:
- ca. 93.3
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Material is not irritating.
- Executive summary:
Material is not irritating.
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