Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 605-637-3 | CAS number: 172529-93-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21.08.2007 - 17.10.2007
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,3-dimethyl 2-[2-(2-amino-6-chloro-9H-purin-9-yl)ethyl]propanedioate
- Cas Number:
- 172529-93-0
- Molecular formula:
- C12 H14 Cl N5 O4
- IUPAC Name:
- 1,3-dimethyl 2-[2-(2-amino-6-chloro-9H-purin-9-yl)ethyl]propanedioate
- Reference substance name:
- 2-Amino-6-chloro-9-(methyl-2-carbomethoxybutanoate-4- yl)purine
- IUPAC Name:
- 2-Amino-6-chloro-9-(methyl-2-carbomethoxybutanoate-4- yl)purine
- Details on test material:
- Formula: C12H14ClN5O4
Appearence: White to pale yellow solid
Expiry date: 31 December 2007
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)IGS BR.
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: A suspension in an aqueous solution of 0.1% Na- carboxymethylcellulose was used.
- Doses:
- limit test 2000 mg/kg
- No. of animals per sex per dose:
- 2 groups with 3 animals; in total 6 females
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 0
- Clinical signs:
- other: Signs of toxicity related to dose levels: No toxic signs were found at animal observation during the entire observation period. A body weight gain in 5/6 animals in both weeks p.a. was noticed, but no body weight gain in 1/6 animals in the 2nd we
- Gross pathology:
- Effects on organs:
No findings were noted at post mortem examination.
Any other information on results incl. tables
Findings in life and post mortem indicate no toxic effects present.
Presence of signs in life: no signs
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
According to REGULATION (EC) No 1272/2008 (CLP) "Fam-stage-1" does not require classification for acute oral toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
