Registration Dossier
Registration Dossier
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EC number: 685-281-3 | CAS number: 2624-17-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro gene mutation:
Gene mutation study in bacteria (Ames test):
1. Experimental results obtained with the substance monosodium salt of cyanuric acid, monohydrate (S. typhimurium: TA100 Spot test: S. typhimurium: TA1535, TA1537, TA97, TA98 and TA100, with and without metabolic activation, genotoxicity negative, no citotoxicity).
2. Experimental results obtained with the substance monosodium salt of cyanuric acid (Salmonella, with and without metabolic activation, genotoxicity negative).
Cytogenicity study in mammalian cells (chromosome aberration test):
3 and 4. Experimental results obtained in two studies with the substance monosodium salt of cyanuric acid (CHO, with and without metabolic activation, genotoxicity negative).
Gene mutation study in mammalian cells (mouse lymphoma assay):
5 and 6. Experimental results obtained in two studies with the substance monosodium salt of cyanuric acid (mouse lymphoma L5178Y cells, with and without metabolic activation, genotoxicity negative).
In vivo gene mutation:
1. Experimental results obtained with the substance monosodium salt of cyanuric acid (male, genotoxicity negative).
Justification for selection of genetic toxicity endpoint
No study was selected, since the results obtained in the in vitro studies (Ames test, chromosome aberrations test and mammalian cell gene mutation assay) and the results obtained in the in vivo studies (chromosome aberrations test) were negative.
Short description of key information:
Experimental results from in vitro gene mutation studies in bacteria (Gridley and Ross, 1980), in vitro gene mutation studies in mammalian cells (Stewart, 1981) and In vitro cytogenicity studies (Kirby, 1981), which concluded that sodium cyanurate is not genotoxic under the conditions of the studies. In addition the results of an in vivo bone marrow cytogenetic assay (chromosome aberration assay, Sharma 1981) showed sodium cyanurate to be non genotoxic.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
It is concluded that the available data indicate that sodium cyanurate has no genotoxicity and therefore does not warrant classification for mutagenicity under DSD or CLP.
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