sodium 1,3,5-triazinane-2,4,6-trione

Endpoint summary

Description of key information

Short description of key information on bioaccumulation potential result: 
Read-across from studies conducted on cyanuric acid and experimental results on sodium cyanurate monohydrate.

Key value for chemical safety assessment

Bioaccumulation potential:

no bioaccumulation potential

Additional information

Experimental results obtained in two studies with the substance monosodium salt of cyanuric acid, monohydrate there is no evidence for bioaccumulation of the compound and there are no major changes in the disposition or metabolism of sodium cyanurate following repeated administration.

Based on the experimental results obtained in 5 studies with the analogue cyanuric acid (data on cumulative excretion curves, absorption, excretion in human and data on distribution and absorption of radiolabelled cyanuric acid in rats) and the molecular weights, the read-across approach is applied and the same results can be extrapolated for sodium cyanurate.

Discussion on bioaccumulation potential result:

1. Based on the experimental results obtained with the substance monosodium salt of cyanuric acid, monohydrate there is no evidence for bioaccumulation of the compound and there are no major changes in the disposition or metabolism of sodium cyanurate following repeated administration.

Read-across: 2. Based on the experimental results obtained with the analogue cyanuric acid (the cumulative excretion curves gave a mean elimination half life of 2.2 h. Analysis of the data by excretion rate gives an elimination half life of 3.5 h with an average A value of 3.4 mg/h. The average observed recovery of cyanuric acid after 20 h is 9.8 mg, whereas the value by curve fitting is 11.5 mg (this probably reflected both skin absorption and oral intake). When 5 volunteers soaked in a swimming pool for 120 min, recovery was 0.03-2.8 mg cyanuric acid (this probably reflected skin absorption only). Cyanuric acid is excreted rapidly, with a half life of approximately 3 h.) the read-across approach is applied and the same results can be extrapolated for substance sodium cyanurate.

3. Based on the experimental results obtained with the analogue cyanuric acid (Orally ingested cyanuric acid appears to be totally excreted unchanged in urine within 24 hours, with t ½ ~1 h. In swimmers, the uptake is largely oral, rates of dermal uptake during immersion (presumably without swimming) being considerably lower. Cyanurate is completely absorbed and excreted unchanged following oral ingestion. When swimming, uptake is largely by oral ingestion) the read-across approach is applied and the same results can be extrapolated for substance sodium cyanurate.

4. Based on the experimental results obtained with the analogue cyanuric acid (14C-Isocyanuric acid, given orally to rats, distributed rapidly, showing highest radioactivity concentrations in blood, liver and kidney.  Maximum concentrations occurred 0.5 h after dosing.  Thereafter radioactivity decreased rapidly, with half lives of approximately 1 h.  The radioactivity was excreted almost entirely in urine as unchanged substance.  When administered dermally, very little radiolabelled isocyanurate was taken up) the read-across approach is applied and the same results can be extrapolated for substance sodium cyanurate.

5. Based on the experimental results obtained with the analogue cyanuric acid (An in vitro model system indicates that cyanurate is poorly absorbed through the skin in all the species tested) the read-across approach is applied and the same results can be extrapolated for substance sodium cyanurate.

6. Based on the experimental results obtained with the analogue cyanuric acid (young competitive, long-distance swimmers swallowed 3.5 times more water (126 mL) than young recreational swimmers (37 mL) the read-across approach is applied and the same results can be extrapolated for substance sodium cyanurate.