Registration Dossier
Registration Dossier
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EC number: 230-437-4 | CAS number: 7139-02-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to an OECD guideline, but GLP information is missing.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- DDH
- IUPAC Name:
- DDH
- Details on test material:
- Sample:DDH
Y our reference: 943510
Our reference: 202032
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Observation period: 3 days
Temperature: 20° c (± 3°)
Relative humidity: 30-70%
Lighting: 12 hours light /12 hours darkness
Feeding: Conventional feeding
body weight: 2 kg to 3 kg.
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- clipped
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- Dose: 0,5 ml of the product.
Test material was administered to an area of 6 cm2 of clipped intact skin for 4
hours. - Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 3 albino male rabbits
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 4 h
- Score:
- 0
- Max. score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The product analysed does not cause any edema nor erythema which could be
detected after the 4 hours of contact of the sample within the test experimentation
conditions.
Non corrosive and non irritant product by skin contact.
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