Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: information from migrated NONS file as per inquiry # [06-0000014790-71-0000], permission to refer granted by ECHA

Data source

Reference
Reference Type:
other: body responsible for the test
Title:
Unnamed
Year:
2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V B4
Principles of method if other than guideline:
no data
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
EC Number:
401-990-0
EC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
Cas Number:
106990-43-6
Molecular formula:
C132H250N32
IUPAC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Vehicle:
other: 0.5g of test substance moistened with tap water and 2-3 of TWEE 80 were applide to the intact skin and covered with a surgical gauze
Amount / concentration applied:
500mg
Duration of treatment / exposure:
4h
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Time point:
other: 4h
Score:
0
Irritation parameter:
other: oedema
Time point:
other: 4h
Score:
0

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU