Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: information from migrated NONS file as per inquiry # [06-0000014790-71-0000], permission to refer granted by ECHA

Data source

Reference
Reference Type:
other: body responsible for the test
Title:
Unnamed
Year:
2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD Guideline 401 Annex V B1
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
EC Number:
401-990-0
EC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
Cas Number:
106990-43-6
Molecular formula:
C132H250N32
IUPAC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine

Test animals

Species:
other: Rat, KFM)Han.wistar (outbred, SPF quality)

Administration / exposure

Vehicle:
other: distilled water containing 4% carboxymethylcellulose sodium salt

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
Male: 5000mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 5000mg/kg bw; Number of animals: 5; Number of deaths: 1
Clinical signs:
Signs of toxicity related to dose levels:
Sedation, dyspnea, ataxia (males), curved body position, ruffed fur. The surviving animals recovered within 7 days.
Gross pathology:
Effects on organs:
Lung: dark-red mottled, not collapsed
Intestines/stomach: meteorism filled with yellowish contents

Killed animals
Lung: dark-red mottled (in 2 animals)

Applicant's summary and conclusion