Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2011
Report date:
1979

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: GLP study
Deviations:
not applicable
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-phenylethanol
EC Number:
200-456-2
EC Name:
2-phenylethanol
Cas Number:
60-12-8
Molecular formula:
C8H10O
IUPAC Name:
2-phenylethanol

Test animals / tissue source

Species:
rabbit

Test system

Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.1 ml
Duration of treatment / exposure:
one time exposure
Observation period (in vivo):
24, 48, 72 h and 7 and 10 days after a one time exposure
Number of animals or in vitro replicates:
6 male rabbits

Results and discussion

In vivo

Results
Irritation parameter:
other: ocular irritation score (Average Draize score)
Basis:
mean
Time point:
other: 24 h
Score:
18.17
Max. score:
110
Reversibility:
fully reversible
Remarks on result:
other: two of the six animals exhibited corneal opacities that lasted until day 7, but both had returned to normal by day 10

Applicant's summary and conclusion