Registration Dossier
Registration Dossier
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EC number: 200-456-2 | CAS number: 60-12-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Fragrance material review on phenethyl alcohol
- Author:
- J.Scognamiglio, et al.
- Year:
- 2 011
- Bibliographic source:
- Food and chemical toxicology, doi: 10.1016/j.fct2011.10.028
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: refer to article
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-phenylethanol
- EC Number:
- 200-456-2
- EC Name:
- 2-phenylethanol
- Cas Number:
- 60-12-8
- Molecular formula:
- C8H10O
- IUPAC Name:
- 2-phenylethanol
Constituent 1
Test animals
- Species:
- human
- Strain:
- other: human
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- other: Diethyl phthalate, Alcohol SD-39C, Alcohol 52
- Amount / concentration applied:
- Diethyl phthalate: 8%
Alcohol SD-39C: 25%
Alcohol 52: 25%
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 1
- Max. score:
- 108
- Reversibility:
- fully reversible
- Remarks on result:
- other: 8% solution in Diethyl Phthalate
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 52
- Max. score:
- 93
- Reversibility:
- fully reversible
- Remarks on result:
- other: 25% solution in Alcohol SD-39C
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 19
- Max. score:
- 50
- Reversibility:
- fully reversible
- Remarks on result:
- other: 25 % solution in Ethanol. 16 of 19 volunteers only showed signs of slight erythema. 3 of 19 individuals showed a well defined erythema confined to the contact site.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
