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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 92/69/EEC, B1
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
423-740-1
EC Name:
-
Cas Number:
10461-98-0
Molecular formula:
C14H15N
IUPAC Name:
2-cyclohexylidene-2-phenylacetonitrile

Test animals

Species:
other: Rat (HanIbm:WIST (SPF))

Administration / exposure

Vehicle:
corn oil

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
619 mg/kg bw
95% CL:
528.45 - 707.12
Remarks on result:
other: Slope of the mortality curve: 7.52
Mortality:
Male: 500 mg/kg bw; Number of animals: 5; Number of deaths: 1
Male: 625 mg/kg bw; Number of animals: 5; Number of deaths: 2
Male: 750 mg/kg bw; Number of animals: 5; Number of deaths: 3
Female: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 625 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 750 mg/kg bw; Number of animals: 5; Number of deaths: 5
Clinical signs:
Signs of toxicity related to dose levels:
All deaths occurred on day 2 or 3 with the exception of 1
female who died on day 5.
The following clinical signs were observed in animals from
all dose groups between 1 hour and 8 days or until death
occured:
sedation, dyspnea, ruffled fur, hunched posture, lying on
stomach, emaciation.
The body weight gain of the animals which survived the
observation period was normal.
Gross pathology:
Effects on organs:
In the animals which were necropsied at termination of
observation, no macroscopic organ findings were noted. In
those who died spontaneously, stomach distended with gas was
frequently observed. No other macroscopic abnormalities were
noted.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU