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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference Type:
Respiratory response of guinea pigs to oil mists.
Costa and Amdur
Bibliographic source:
Am Ind Hyg Assoc J. Vol. 40 (8): 673-679.

Materials and methods

Test guideline
equivalent or similar to guideline
OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Paraffin oils/waxes
Paraffin oils/waxes
Details on test material:
Paraffin oils/waxes

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Study results:


At ≤40 mg/m3: no alterations were observed; No respiratory irritant effects were seen.

Applicant's summary and conclusion

Repeated dose toxicity studies in animals exposed to Mineral Paraffin Oil via inhalation report similar results being concentration-related accumulation of alveolar macrophages with oil droplets in the lung. Exposure to high aerosol concentrations result in inflammatory responces (lipid pneumonia) to the presence of deposited aerosols.