Registration Dossier
Registration Dossier
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EC number: 232-384-2 | CAS number: 8012-95-1 Liquid hydrocarbons from petroleum.
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- publication
- Title:
- Respiratory response of guinea pigs to oil mists.
- Author:
- Costa and Amdur
- Year:
- 1 979
- Bibliographic source:
- Am Ind Hyg Assoc J. Vol. 40 (8): 673-679.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Paraffin oils/waxes
- IUPAC Name:
- Paraffin oils/waxes
- Details on test material:
- Paraffin oils/waxes
Constituent 1
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Study results:
At ≤40 mg/m3: no alterations were observed; No respiratory irritant effects were seen.
Applicant's summary and conclusion
- Conclusions:
- Repeated dose toxicity studies in animals exposed to Mineral Paraffin Oil via inhalation report similar results being concentration-related accumulation of alveolar macrophages with oil droplets in the lung. Exposure to high aerosol concentrations result in inflammatory responces (lipid pneumonia) to the presence of deposited aerosols.
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