Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
weight of evidence
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference Type:
review article or handbook
Toxicological Profile for Total Petroleum Hydrocarbons (TPH)
Bibliographic source:
ATSDR, September 1999.

Materials and methods

Test guideline
according to guideline
other: Scientific peer review report
Principles of method if other than guideline:
Scientific peer review report
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Paraffin oils/waxes
Paraffin oils/waxes

Results and discussion

Any other information on results incl. tables

Study results:

Aliphatic hydrocarbon C>16 (C16 –C35) fraction may be poorly absorbed via oral, inhalation or dermal exposure routes, distributed to the liver and fatty tissues, slowly metabolized to fatty acids or triglycerides, and excreted with the feces via the bile and as urine metabolites.


The data on toxicokinetics of Mineral Paraffin Oil suggest that long-chain aliphatic hydrocarbons have only limited absorption potential after inhalation, oral and ingestion exposure routes. Thus, animal studies show that up to 95 -99% of ingested food-grade mineral oil leaves the body unchanged with the faeces, and only up to 5% being absorbed via the intestinal mucosa. The absorbed Mineral Paraffin Oil is distributed to the liver and fatty tissues. Aliphatic hydrocarbons in this fraction are not expected to undergo extensive metabolism in animals or humans.

Applicant's summary and conclusion