Registration Dossier
Registration Dossier
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EC number: 448-050-6 | CAS number: 444065-11-6
Endpoint summary
Administrative data
Description of key information
Skin irritation (OECD 404): not irritating
Eye irritation (OECD 405): not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
A study assessing the skin irritation potential of 2-(4-tert-butylphenyl)-6-cyano-5-[bis(ethoxycarbonylmethyl)carbamoyloxy]-1 H-pyrrolo[1 ,2-b][1 ,2,4]triazole-7-carboxylic acid-2,6-di-tert-butyl-4-methyl-cyclohexyl ester (UC-141) was performed according to OECD guideline 404 with 3 rabbits (Hooiveld, 2003). 0.5 g of the test substance was moistened with 1.0 mL of water and applied to the shaved skin of the rabbits under semiocclusive conditions, for 4 hours. There were no skin irritation effects observed in any of the animals.
To evaluate the eye irritation potential of UC-141, a study was performed according to OECD guideline 405 (Hooiveld, 2003). 0.1 mL of the test substance was instilled into one eye of 3 rabbits. The eyes were not washed after instillation. 1/3 rabbits had slight iridial irritation 1 hour after instillation, which cleared within 24 hours. No effects were noted on the cornea. Minimal effects were observed on the conjunctivae (redness and chemosis), which were completely reversible within 72 hours.
Justification for classification or non-classification
The available data on skin irritation and on eye irritation of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.
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