Cyclopropanecarbonitrile, 1-amino-, hydrochloride (1:1)

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Given the precision required (the solubility is determined as a range), no sufficient human error is expected which could lead to a non reliable result.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Report date:

2010

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: European Pharmacopoeia 5.0 : Solubility

Principles of method if other than guideline:

1-Tared a dried volumetric flask at a fixed temperature of 20°C.
2-Fill in the flask with 100mg of the substance
3-Add 0.1ml of water and check if the sustance is solubilized (very soluble): if not go to step 4)
4-Add 0.9mL of water and check if the sustance is solubilized (easily soluble): if not go to step 5)
5-Add 2mL of water and check if the sustance is solubilized (soluble): if not go to step 6)
6-Add 7mL of water and check if the sustance is solubilized (moderately soluble): if not go to step 7)
7-Tared a dried volumetric flask at a fixed temperature of 20°C.
Fill in the flask with 10mg of the substance, add 10mL of water and check if the sustance is solubilized (slightly soluble): if not go to step 8)
8-Tared a dried volumetric flask at a fixed temperature of 20°C.
Fill in the flask with 1mg of the substance, add 10mL of water and check if the sustance is solubilized (very poorly soluble).

GLP compliance:

yes

Type of method:

other: European Pharmacopoeia 5.0 : Solubility

Test material

Test material information

Constituent 1

Reference substance name:

1-Amino-1-cyclopropanecarbonitrile hydrochloride

EC Number:

629-718-8

Cas Number:

127946-77-4

Molecular formula:

C4H7N2Cl

IUPAC Name:

1-Amino-1-cyclopropanecarbonitrile hydrochloride

Constituent 2

Reference substance name:

1-aminocyclopropane-1-carbonitrile hydrochloride

IUPAC Name:

1-aminocyclopropane-1-carbonitrile hydrochloride

Results and discussion

Water solubility

Water solubility:

>= 100 - <= 1 000 mg/L

Temp.:

20 °C

pH:

ca. 2.6

Details on results:

100mg of the substance is soluble in 10ml of water.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
Solubility at 20°C in water is 100 to 1000mg/L =>The substance is moderately soluble according to European Pharmacopoeia 5.0