Registration Dossier
Registration Dossier
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EC number: 412-050-4 | CAS number: 125109-85-5 FLORHYDRAL
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- other: no data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EC B. 6 (Magnusson and Kligman)
- GLP compliance:
- yes
- Type of study:
- other: no data
Test material
- Reference substance name:
- β-methyl-3-(1-methylethyl)benzenepropanal
- EC Number:
- 412-050-4
- EC Name:
- β-methyl-3-(1-methylethyl)benzenepropanal
- Cas Number:
- 125109-85-5
- Molecular formula:
- C13H18O
- IUPAC Name:
- 3-[3-(propan-2-yl)phenyl]butanal
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Himalayan
Study design: in vivo (LLNA)
- Concentration:
- Concentration of test material and vehicle used at induction:
a) Intradermal: 0.5 % in ethanol
b) Epidermal: 50% in ethanol
Concentration of test material and vehicle use for each challenge:
a) 30% in ethanol - No. of animals per dose:
- Number of animals in test group:20
Number of animals in negative control group: 10
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 30%
- No. with + reactions:
- 1
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 30%. No with. + reactions: 1.0. Total no. in groups: 20.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 30%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 30%. No with. + reactions: 0.0. Total no. in groups: 20.0.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 30%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 30%. No with. + reactions: 0.0. Total no. in groups: 10.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 30%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 30%. No with. + reactions: 0.0. Total no. in groups: 10.0.
In vivo (LLNA)
Results
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: Signs of irritation during induction: No signs correlated with the test article. Evidence of sensitization of each challange concentration: 1 of 20 animals
Applicant's summary and conclusion
- Interpretation of results:
- no data
- Remarks:
- Migrated information not classified
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